CAS 508-52-1

Ouabagenin

Description:

Ouabagenin is a cardiac glycoside, a type of compound known for its ability to influence heart function. It is derived from the seeds of the African plant Strophanthus gratus and is structurally related to other glycosides like ouabain. Ouabagenin exhibits a steroidal structure with a lactone ring, which is characteristic of cardiac glycosides. Its primary action involves inhibiting the Na+/K+ ATPase enzyme, leading to increased intracellular sodium and calcium concentrations, ultimately enhancing cardiac contractility. This mechanism makes it of interest in pharmacology, particularly for its potential therapeutic effects in heart failure and arrhythmias. However, due to its potent effects, ouabagenin can also be toxic, necessitating careful dosing and monitoring. In addition to its pharmacological properties, ouabagenin has been studied for its potential effects on various biological systems, including its role in modulating cellular signaling pathways. As with many cardiac glycosides, the use of ouabagenin requires a thorough understanding of its pharmacokinetics and pharmacodynamics to ensure safe and effective application.

Formula: C₂₃H₃₄O₈

InChI: InChI=1S/C23H34O8/c1-20-9-16(26)19-15(23(20,30)5-3-14(20)12-6-18(28)31-10-12)2-4-21(29)8-13(25)7-17(27)22(19,21)11-24/h6,13-17,19,24-27,29-30H,2-5,7-11H2,1H3/t13-,14+,15+,16+,17+,19+,20+,21-,22+,23-/m0/s1

InChI key: InChIKey=BXSABLKMKAINIU-QOHCMMFCSA-N

SMILES: C(O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(C[C@H]3O)[C@H](CC4)C5=CC(=O)OC5)(CC[C@]1(O)C[C@@H](O)C[C@H]2O)[H])[H]

Synonyms:

• (1Beta,3Beta,5Beta,8Xi,9Xi,11Alpha)-1,3,5,11,14,19-Hexahydroxycard-20(22)-Enolide
• (1β,3β,5β,11α)-1,3,5,11,14,19-Hexahydroxycard-20(22)-enolide
• 1,3,5,11,14,19-Hexahydroxycard-20(22)-Enolide
• 1-beta,3-beta,5,11-alpha,14,19-Hexahydroxy-5-beta-card-20(22)-enolide
• 1β,3β,5,11α,14,19-Hexahydroxy-5β-20(22)-cardenolide
• 5-beta-Card-20(22)-enolide, 1-beta,3-beta,5,11-alpha,14,19-hexahydroxy-
• 5beta-Card-20(22)-enolide, 1beta,3beta,5,11alpha,14,19-hexahydroxy- (8CI)
• 5β-Card-20(22)-enolide, 1β,3β,5,11α,14,19-hexahydroxy-
• Brn 0060306
• Card-20(22)-enolide, 1,3,5,11,14,19-hexahydroxy-, (1-beta,3-beta,5-beta,11-alpha)- (9CI)
• Card-20(22)-enolide, 1,3,5,11,14,19-hexahydroxy-, (1β,3β,5β,11α)-
• Nsc 97088
• Ouabain genin
• g-Strophanthidin
• Ouabagenin

Ouabagenin

CAS: 508-52-1

Ouabagenin, a naturally occurring LXR ligand with selective agonist activity, functions as an EC 3.6.3.9 (Na(+)/K(+)-transport ATPase) inhibitor [1] [2].

Formula: C₂₃H₃₄O₈

Color and Shape: Solid

Molecular weight: 438.51

Ref: TM-TN7752

Ouabagenin

CAS: 508-52-1

Formula: C₂₃H₃₄O₈

Purity: 95%~99%

Molecular weight: 438.517

Ref: BP-BP1048

Ouabagenin

Controlled Product

CAS: 508-52-1

Formula: C₂₃H₃₄O₈

Color and Shape: Neat

Molecular weight: 438.511

Ref: TR-O619630