CAS 508-77-0

Cymarin

Description:

Cymarin, with the CAS number 508-77-0, is a chemical compound classified as a cardiac glycoside, primarily derived from the plant species Digitalis purpurea, commonly known as foxglove. It exhibits a structure characterized by a steroid nucleus with a lactone ring, which is typical of glycosides. Cymarin is known for its pharmacological effects, particularly its ability to influence cardiac function by increasing the force of heart contractions and regulating heart rhythm, making it relevant in the treatment of certain heart conditions. The compound operates by inhibiting the Na+/K+ ATPase enzyme, leading to increased intracellular calcium levels in cardiac cells. In addition to its therapeutic uses, cymarin can be toxic in high doses, leading to symptoms such as nausea, vomiting, and arrhythmias. Its use is carefully monitored in clinical settings, and it is essential to consider potential interactions with other medications. Overall, cymarin exemplifies the dual nature of many natural compounds, offering both therapeutic benefits and risks.

Formula: C₃₀H₄₄O₉

InChI: InChI=1/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22+,23+,25+,26-,27-,28+,29+,30+/m1/s1

InChI key: InChIKey=XQCGNURMLWFQJR-ZNDDOCHDSA-N

SMILES: C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@]1(O)C[C@@H](O[C@H]6C[C@H](OC)[C@H](O)[C@@H](C)O6)CC2)[H])[H]

Synonyms:

• (3beta,5beta)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta)-3-[(2,6-dideoxy-3-O-methylhexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,8alpha)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,8xi,9xi,10xi,13xi,14xi,17xi)-3-[(2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3β,5β)-3-[(2,6-Dideoxy-3-O-methyl-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Alvonal MR
• Card-20(22)-enolide, 3-[(2,6-dideoxy-3-O-methyl-β-<span class="text-smallcaps">D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• Cymarine
• K-Strophanthin-α
• NSC 7522
• Strophantin K
• WV 90043a
• (+)-Cymarin
• Card-20(22)-enolide, 3-[(2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• (3β,5β)-3-[(2,6-Dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Cymarin
• (3beta,5beta)-3-[(2,6-dideoxy-4-O-beta-D\-glucopyranosyl-3-O-methyl-beta-D\-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• KOMBETIN
• STROPHANTHIN K
• CYMARIN: TECH., 90%
• K-STROPHANTHIN-ALPHA
• strofantidinacimaroside
• K-STROPHANTHIDIN-D-CYMAROSIDE
• 3β-[(3-O-Methyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide
• CIMARIN
• K STROPHANTHIN
• CYMARIN CRYSTALLINE
• CYMARIN(P)
• 5-beta-card-20(22)-enolide,3-beta-(beta-d-cymarosyloxy)-5,14-dihydroxy-19-ox
• alvonalmr
• 3β-[(2,6-Dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5β,14β-card-20(22)-enolide

Cymarin

CAS: 508-77-0

Cymarin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₃₀H₄₄O₉

Purity: (HPLC) ≥90%

Color and Shape: Powder

Molecular weight: 548.67

Ref: 11-0809

Cymarin

CAS: 508-77-0

Natural glycoside

Formula: C₃₀H₄₄O₉

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 548.68

Ref: 5G-89838

Cymarin

Controlled Product

CAS: 508-77-0

Applications Cymarin is a pure allelochemicals that is a potent growth inhibitor in plants.
References Akhtar, Y.,e t al.: J. Appl. Entomol., 128, 32 (2004);

Formula: C₃₀H₄₄O₉

Color and Shape: Neat

Molecular weight: 548.66

Ref: TR-C989908

Cymarin

CAS: 508-77-0

Cymarin is a cardiac glycoside, which is a class of organic compounds commonly derived from certain plant species, notably within the family Apocynaceae. It is extracted primarily from the plant *Apocynum cannabinum* and related species. Cymarin functions by inhibiting the sodium-potassium ATPase pump on cellular membranes. This inhibition leads to an increase in intracellular sodium levels, which in turn affects calcium exchange and enhances cardiac muscle contraction. This mode of action makes it a potent inotropic agent.

Formula: C₃₀H₄₄O₉

Purity: Min. 95%

Molecular weight: 548.66 g/mol

Ref: 3D-FC156960

Cymarin

CAS: 508-77-0

Cymarin is a natural product for research related to life sciences. The catalog number is TN3746 and the CAS number is 508-77-0.

Formula: C₃₀H₄₄O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 548.67

Ref: TM-TN3746