CAS 509-67-1

Pholcodine

Description:

Pholcodine is a semi-synthetic opioid used primarily as a cough suppressant in various over-the-counter medications. It is classified as a morphinan derivative and exhibits antitussive properties, making it effective in alleviating dry coughs. Pholcodine acts on the central nervous system by inhibiting the cough reflex in the brain, providing relief without the analgesic effects commonly associated with other opioids. Its chemical structure features a phenolic hydroxyl group, contributing to its pharmacological activity. Pholcodine is generally well-tolerated, but like other opioids, it can lead to side effects such as drowsiness, constipation, and potential dependency with prolonged use. It is important to note that pholcodine is not recommended for use in certain populations, such as individuals with respiratory conditions or those who are pregnant. Regulatory status may vary by country, and it is often available in combination with other active ingredients in cough formulations. As with any medication, it is essential to use pholcodine under the guidance of a healthcare professional to ensure safety and efficacy.

Formula: C₂₃H₃₀N₂O₄

InChI: InChI=1/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16?,17-,18+,22+,23+/m1/s1

InChI key: InChIKey=GPFAJKDEDBRFOS-FKQDBXSBSA-N

SMILES: O[C@@H]1[C@]2([C@]34C=5C(O2)=C(OCCN6CCOCC6)C=CC5C[C@]([C@@]3(C=C1)[H])(N(C)CC4)[H])[H]

Synonyms:

• (5Alpha,6Alpha)-17-Methyl-3-(2-Morpholin-4-Ylethoxy)-7,8-Didehydro-4,5-Epoxymorphinan-6-Ol
• (5α,6α)-7,8-Didehydro-4,5-epoxy-17-methyl-3-[2-(4-morpholinyl)ethoxy]morphinan-6-ol
• 3-[2-(4-Morpholinyl)ethyl]morphine
• Biocalyptol
• Codylin
• Ethnine
• Folcodin
• Folcodine
• Galenphol
• Galphol
• Glycodine
• Hibernyl
• Homocodeine
• Memine
• Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-17-methyl-3-[2-(4-morpholinyl)ethoxy]-, (5α,6α)-
• Morphinan-6α-ol, 7,8-didehydro-4,5α-epoxy-17-methyl-3-(2-morpholinoethoxy)-
• Morphine, 3-O-(2-morpholinoethyl)-
• Morphine, O³-(2-morpholinoethyl)-
• Morpholinylethylmorphine
• Neocodine
• O-2-Morpholinoethylmorphine
• O3-(2-morpholinoethyl)morphine
• O³-(2-Morpholinoethyl)morphine
• Pectolin
• Pholcodine (PI)
• Pholtex
• Tussokon
• Tuxi Forte
• Weifacodine
• β-Morpholinylethylmorphine

Pholcodine

Controlled Product

CAS: 509-67-1

Applications Antitussive; an opioid cough suppressant. Controlled Substance.
References Findlay, J.W.A.: J. Clin. Pharm. Therap., 13, 5 (1988); Chen, Z.R. et al.: Br. J. Clin. Pharmacol., 26, 445 (1988); Maurer, H.H. et al.: Arzneim.-Forsch., 40, 546 (1990);

Formula: C₂₃H₃₀N₂O₄

Color and Shape: Neat

Molecular weight: 398.50

Ref: TR-P351500

PHOLCODINE CRS - * NARC

Controlled Product

CAS: 509-67-1

PHOLCODINE CRS - * NARC

Formula: C₂₃H₃₀N₂O₄

Color and Shape: Powder

Molecular weight: 398.4953

Ref: 41-Y0000761

PHOLCODINE FOR PEAK IDENTIFICATION CRS - * NARC (PHOLCODINE MONOHYDRATE)

Controlled Product

CAS: 509-67-1

PHOLCODINE FOR PEAK IDENTIFICATION CRS - * NARC (PHOLCODINE MONOHYDRATE)

Formula: C₂₃H₃₀N₂O₄

Color and Shape: Powder

Molecular weight: 398.4953

Ref: 41-Y0000798

Pholcodine (1.0mg/ml in Acetonitrile)

Controlled Product

CAS: 509-67-1

Formula: C₂₃H₃₀N₂O₄

Color and Shape: Single Solution

Molecular weight: 398.50

Ref: TR-KIT6985

Pholcodine-d3

Controlled Product

CAS: 509-67-1

Applications A labelled antitussive; an opioid cough suppressant. Controlled Substance.
References Findlay, J.W.A.: J. Clin. Pharm. Therap., 13, 5 (1988); Chen, Z.R. et al.: Br. J. Clin. Pharmacol., 26, 445 (1988); Maurer, H.H. et al.: Arzneim.-Forsch., 40, 546 (1990);

Formula: C₂₃H₂₇D₃N₂O₄

Color and Shape: Neat

Molecular weight: 401.51

Ref: TR-P351502

Pholcodine-d3 (1 mg/mL in Acetonitrile)

Controlled Product

CAS: 509-67-1

Formula: C₂₃H₂₇D₃N₂O₄

Color and Shape: Single Solution

Molecular weight: 401.51

Ref: TR-KIT6990

Pholcodine

Controlled Product

CAS: 509-67-1

Pholcodine is a cough suppressant that is used to relieve the symptoms of dry, tickly coughs. It does not have any analgesic properties and should not be used for the treatment of acute bronchitis or asthma. The drug is available in three forms: pholcodine bitartrate, pholcodine citrate, and pholcodine hydrochloride. Pholcodine is a tertiary amine that binds to cell nuclei and has been shown to cause DNA damage as well as inhibit protein synthesis. The drug has been shown to produce long-term toxicity in rats, but its clinical relevance to humans is unknown. A fluorescence detector was used to measure the sensitivity of the drug in detecting low levels of antibodies against it in human serum by measuring the change in fluorescence intensity upon binding with an antibody.

Formula: C₂₃H₃₀N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 398.5 g/mol

Ref: 3D-FP27013