CAS 50925-79-6

Colestipol

Description:

Colestipol is a synthetic polymeric compound primarily used as a cholesterol-lowering medication. It functions as a bile acid sequestrant, binding bile acids in the intestine and preventing their reabsorption, which leads to increased excretion and a subsequent reduction in serum cholesterol levels. Colestipol is typically presented as a white to off-white powder and is soluble in water, although it may require stirring or shaking to achieve a uniform suspension. The substance has a high molecular weight and is characterized by its ability to form complexes with bile acids, which is crucial for its therapeutic action. It is administered orally, often in the form of tablets or granules, and may be used in conjunction with dietary modifications. Common side effects include gastrointestinal disturbances, such as constipation and bloating. As with any medication, it is essential to monitor for potential interactions with other drugs, as colestipol can affect the absorption of certain medications. Overall, colestipol plays a significant role in managing hyperlipidemia and promoting cardiovascular health.

Formula: C₁₁H₂₈ClN₅O

InChI: InChI=1/C8H23N5.C3H5ClO/c9-1-3-11-5-7-13-8-6-12-4-2-10;4-1-3-2-5-3/h11-13H,1-10H2;3H,1-2H2

Synonyms:

• Colestipolum
• Colestipolum [INN-Latin]
• N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine - 2-(chloromethyl)oxirane (1:1)
• Cholestabyl
• U 26597A

Colestipol

CAS: 50925-79-6

Colestipol is a bile acid sequestrant, which is a type of polymeric anion-exchange resin derived from a synthetic, non-absorbable source. Its mode of action involves binding bile acids in the intestine, thereby interrupting their enterohepatic circulation. This binding process forms an insoluble complex that is excreted in feces, reducing the bile acid pool and prompting the liver to use circulating cholesterol to synthesize new bile acids. Consequently, this results in a decrease in serum cholesterol levels.Colestipol is primarily used in the management of hypercholesterolemia, particularly in patients who cannot tolerate statins or require additional cholesterol-lowering support. Its applications extend to both primary and secondary prevention of coronary artery disease due to its role in lowering low-density lipoprotein (LDL) cholesterol levels. While effective, its usage must be carefully monitored due to potential gastrointestinal side effects and possible interactions with the absorption of other medications and nutrients.

Ref: 3D-FC184561