CAS 50935-04-1

Carubicin

Description:

Carubicin, with the CAS number 50935-04-1, is an anthracycline antibiotic that is primarily derived from the bacterium Streptomyces carubensis. It exhibits potent antitumor activity, making it a subject of interest in cancer research and treatment. The compound functions by intercalating into DNA, disrupting the replication process, and ultimately leading to cell death, particularly in rapidly dividing cancer cells. Carubicin is characterized by its complex polycyclic structure, which is typical of anthracyclines, and it possesses various functional groups that contribute to its biological activity. Its pharmacological profile includes a range of side effects, similar to other drugs in its class, such as cardiotoxicity and myelosuppression. Due to these effects, careful monitoring is essential during its therapeutic use. Research continues to explore its efficacy and safety, as well as potential combinations with other chemotherapeutic agents to enhance its anticancer effects while minimizing adverse reactions.

Formula: C₂₆H₂₇NO₁₀

InChI: InChI=1S/C26H27NO10/c1-9-21(30)13(27)6-16(36-9)37-15-8-26(35,10(2)28)7-12-18(15)25(34)20-19(23(12)32)22(31)11-4-3-5-14(29)17(11)24(20)33/h3-5,9,13,15-16,21,29-30,32,34-35H,6-8,27H2,1-2H3/t9-,13-,15-,16-,21+,26-/m0/s1

InChI key: InChIKey=XREUEWVEMYWFFA-CSKJXFQVSA-N

SMILES: O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4O)C[C@](C(C)=O)(O)C1)[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5

Synonyms:

• (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-L-lyxo-hexopyranoside
• (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
• (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside
• (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)-
• Antibiotic R 588A
• Carminomicin I
• Carminomycin I
• NSC 180024
• Nci 180024
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)-
• (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione

Carubicin

CAS: 50935-04-1

Carubicin, an anthracycline antibiotic from Actinomadura carminata, disrupts DNA replication and repair by intercalating DNA and inhibiting topoisomerase II.

Formula: C₂₆H₂₇NO₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 513.49

Ref: TM-T21328

Carminomycin Trifluoroacetate

CAS: 50935-04-1

Formula: C₂₆H₂₇NO₁₀·C₂HF₃O₂

Molecular weight: 513.51 114.02

Ref: 4Z-C-302001