CAS 51-20-7
:5-Bromouracil
Description:
5-Bromouracil is a halogenated pyrimidine derivative, specifically a brominated analog of uracil. Its chemical formula is C4H3BrN2O2, and it features a bromine atom at the 5-position of the uracil ring. This compound is primarily known for its role in molecular biology and biochemistry, particularly as a nucleoside analog that can interfere with DNA synthesis and replication. 5-Bromouracil can substitute for thymine in DNA, leading to mutations during DNA replication due to its ability to pair with adenine or guanine under certain conditions. It is often used in research to study DNA replication and repair mechanisms. The substance is typically a white to off-white crystalline powder and is soluble in water and organic solvents. Due to its potential mutagenic properties, handling 5-bromouracil requires caution, and it is important to follow safety protocols in laboratory settings.
Formula:C4H3BrN2O2
InChI:InChI=1S/C4H3BrN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key:InChIKey=LQLQRFGHAALLLE-UHFFFAOYSA-N
SMILES:O=C1C(Br)=CNC(=O)N1
Synonyms:- 2,4(1H,3H)-Pyrimidinedione, 5-bromo-
- 2,4-Dihydroxy-5-Bromopyrimidine
- 5-Bromo-2,4(1H,3H)-pyrimidinedione
- 5-Bromo-2,4-dihydroxypyrimidine
- 5-Bromo-2,4-pyrimidinedione
- 5-Bromopyrimidine-2,4-diol
- 5-Bromouracile
- 5-Bromouracilo
- 5-Bromuracil
- 5-bromopyrimidine-2,4(1H,3H)-dione
- Bromouracil
- Nsc 19940
- Uracil, 5-bromo-
- See more synonyms
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Found 11 products.
5-Bromouracil
CAS:Formula:C4H3BrN2O2Purity:>98.0%(T)Color and Shape:White to Yellow to Orange powder to crystalMolecular weight:190.985-Bromouracil, 98+%
CAS:<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>Formula:C4H3BrN2O2Purity:98+%Color and Shape:White to cream to pale brown, PowderMolecular weight:190.985-Bromouracil
CAS:<p>5-Bromouracil disrupts nucleosome positioning by inducing A-form-like DNA.</p>Formula:C4H3BrN2O2Purity:99.51%Color and Shape:Prisms From Water Physical Description White Powder (Ntp 1992)Molecular weight:190.985-Bromouracil
CAS:<p>5-Bromouracil is a cytotoxic agent that inhibits the synthesis of DNA by inhibiting the enzyme thymine-5-bromo-2'-deoxyribonucleotide synthetase. It also has genotoxic effects on the organism, which can be observed in transfection experiments with human lymphocytes and polymerase chain reaction (PCR) experiments. 5-Bromouracil binds to the hydroxyl group of thymine and interacts with the nucleic acid bases, blocking the process of DNA synthesis. This drug is used to treat cancer in humans, but it is also toxic to eosinophils, which are white blood cells that produce chemicals such as peroxidases that help fight infections. The mechanism of action for 5-Bromouracil is not yet fully understood.</p>Formula:C4H3BrN2O2Purity:Min. 95%Color and Shape:Yellow PowderMolecular weight:190.98 g/mol5-Bromouracil
CAS:Formula:C4H3BrN2O2Purity:97%Color and Shape:Solid, Crystalline Powder or PowderMolecular weight:190.9845-Bromouracil extrapure, 99%
CAS:Formula:C4H3N2O2BrPurity:min. 99%Color and Shape:White to off-white, Crystalline powder, ClearMolecular weight:190.985-Bromouracil
CAS:Controlled Product<p>Applications A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine.<br>References Skavronskaya, G., et al.: Mutat. Res., 6, 319 (1968),<br></p>Formula:C4H3BrN2O2Color and Shape:Off White PowderMolecular weight:190.98
