CAS 51-35-4

L-Hydroxyproline

Description:

L-Hydroxyproline is a non-proteinogenic amino acid that is a derivative of proline, characterized by the presence of a hydroxyl group on the pyrrolidine ring. It is commonly found in collagen and plays a crucial role in stabilizing the triple helix structure of this protein, which is essential for the integrity of connective tissues. L-Hydroxyproline is a white crystalline solid that is soluble in water and has a slightly acidic nature due to the presence of the carboxyl group. Its molecular formula is C5H9NO3, and it has a molecular weight of approximately 131.13 g/mol. This amino acid is important in various biochemical processes, including collagen synthesis and metabolism. Additionally, L-Hydroxyproline is utilized in research and pharmaceutical applications, particularly in studies related to fibrosis and wound healing. Its unique structural properties and biological significance make it a valuable compound in both scientific and medical fields.

Formula: C₅H₉NO₃

InChI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

InChI key: InChIKey=PMMYEEVYMWASQN-DMTCNVIQSA-N

SMILES: C(O)(=O)[C@@H]1C[C@@H](O)CN1

Synonyms:

• (-)-4-Hydroxy-2-pyrrolidinecarboxylic acid
• (2S,4R)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid
• (2S,4R)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid
• (2S,4R)-4-Hydroxyproline
• (4R)-4-Hydroxy-<span class="text-smallcaps">L</span>-proline
• (4R)-4-hydroxy-L-proline
• (4R,2S)-Hydroxyproline
• (R)-4-Hydroxy-(S)-proline
• (R)-4-Hydroxy-<span class="text-smallcaps">L</span>-proline
• (R)-4-Hydroxy-L-proline
• (S)-Hydroxyproline
• 1-Hydroxyproline
• 1-hydroxy-L-proline
• 3-hydroxy-L-proline
• 4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic acid
• 4(R)-Hydroxyproline
• 4-Hydroxy-(S)-proline
• 4-Hydroxy-<span class="text-smallcaps">L</span>-proline
• 4-Hydroxy-L-proline
• 4-Hydroxyproline
• 4-L-Hydroxyproline
• 4-hydroxy-L-proline (trans)
• 4-trans-Hydroxy-<span class="text-smallcaps">L</span>-proline
• 4-trans-Hydroxy-L-proline
• <span class="text-smallcaps">L</span>-4-Hydroxyproline
• <span class="text-smallcaps">L</span>-Hydroxyproline
• <span class="text-smallcaps">L</span>-Hypro
• <span class="text-smallcaps">L</span>-Proline, 4-hydroxy-, (4R)-
• <span class="text-smallcaps">L</span>-Proline, 4-hydroxy-, trans-
• <span class="text-smallcaps">L</span>-trans-4-Hydroxyproline
• H-Hyp-OH
• Hydroxy-<span class="text-smallcaps">L</span>-proline
• Hydroxy-L-proline
• Hydroxyproline
• Hydroxyproline, L-
• Hypro
• L-4-Hydroxyprolin
• L-4-Hydroxyproline
• L-4-hidroxiprolina
• L-Hydroxyproline
• L-Hypro
• L-Proline, 4-hydroxy-, (4R)-
• L-Proline, 4-hydroxy-, trans-
• L-trans-4-Hydroxyproline
• L_s-Hydroxyproline
• Ls-Hydroxyproline
• Nsc 46704
• Proline, 4-hydroxy-
• Proline, 4-hydroxy-, <span class="text-smallcaps">L</span>-
• Proline, 4-hydroxy-, L-
• Trans-4-hydroxyl-L-proline
• delta-Hydroxyproline
• trans-(2S,4R)-4-Hydroxy-<span class="text-smallcaps">L</span>-proline
• trans-4-Hydroxy-<span class="text-smallcaps">L</span>-proline
• trans-4-Hydroxyproline
• trans-<span class="text-smallcaps">L</span>-4-Hydroxyproline
• trans-<span class="text-smallcaps">L</span>-Hydroxyproline
• trans-L-4-Hydroxyproline
• trans-L-Hydroxyproline

trans-4-Hydroxy-L-proline

CAS: 51-35-4

Formula: C₅H₉NO₃

Purity: >99.0%(T)(HPLC)

Color and Shape: White powder to crystaline

Molecular weight: 131.13

Ref: 3B-H0296

trans-4-Hydroxy-L-proline, 99+%

CAS: 51-35-4

trans-4-Hydroxy-L-proline is used as a reagent for the preparation of neuroexcitatory kainoids and antifungal echinocandins. It is also involved in the synthesis of chiral ligands for enantioselective ethylation of aldehydes. This Thermo Scientific Chemicals brand product was originally part of the

Formula: C₅H₉NO₃

Purity: 99+%

Color and Shape: White to pale cream, Crystals or powder or crystalline powder

Molecular weight: 131.13

Ref: 02-A11851

H-Hyp-OH

CAS: 51-35-4

Kristensen et al. achieved the selective O-acylation of unprotected trans-hydroxyproline.

Formula: C₅H₉NO₃

Color and Shape: White

Molecular weight: 131.13

Ref: 01-4002357

L-4-Hydroxyproline

CAS: 51-35-4

Formula: C₅H₉NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 131.1299

Ref: IN-DA0035PX

L-Hydroxyproline

CAS: 51-35-4

L-Hydroxyproline

Purity: ≥98%

Molecular weight: 131.13g/mol

Ref: 54-BUP18166

trans-4-Hydroxy-L-proline, GlenCell™, suitable for cell culture

CAS: 51-35-4

Formula: C₅H₉NO₃

Purity: (dried basis) 99.0 - 101.0 %

Color and Shape: White crystalline powder

Molecular weight: 131.13

Ref: 7W-GM0902

trans-4-Hydroxy-L-Proline

CAS: 51-35-4

Formula: C₅H₉NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 131.13

Ref: 4Z-P-166019

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid

CAS: 51-35-4

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid

Formula: C₅H₉NO₃

Purity: ≥95%

Color and Shape: white crystals

Molecular weight: 131.12985g/mol

Ref: 54-OR6733

trans-4-Hydroxy-L-proline

CAS: 51-35-4

Formula: C₅H₉NO₃

Purity: 98.5 - 101.5 %

Color and Shape: White to off-white crystalline powder, or colourless crystals

Molecular weight: 131.13

Ref: 7W-GM7180

L-Hydroxyproline

CAS: 51-35-4

Formula: C₅H₉NO₃

Purity: 95%~99%

Molecular weight: 131.131

Ref: BP-BP3523

L-Hydroxyproline

CAS: 51-35-4

L-Hydroxyproline (L-Hydroxyprolin) is one of the hydroxyproline (Hyp) isomers.

Formula: C₅H₉NO₃

Purity: 99.77% - 99.92%

Color and Shape: Solid

Molecular weight: 131.13

Ref: TM-T2A2476

trans-4-Hydroxy-L-proline

Controlled Product

CAS: 51-35-4

Applications A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001);

Formula: C₅H₉NO₃

Color and Shape: Neat

Molecular weight: 131.13

Ref: TR-H952376

trans-4-Hydroxy-L-proline

CAS: 51-35-4

Proline is a non-essential amino acid that is found in the basic structure of collagen. Proline has been shown to have physiological effects, including a protective effect on the myocardium, and can be used as an analytical method for detecting proline residues in biological samples. Trans-4-Hydroxy-L-proline is a proline derivative that has been shown to inhibit collagenase activity in vitro. It was also shown to have an optimum concentration of 1 mM and a matrix effect at pH 6.5. The model system used to study trans-4-hydroxy-l-proline was the enzyme extracted from rat liver.

Formula: C₅H₉NO₃

Color and Shape: White Powder

Molecular weight: 131.13 g/mol

Ref: 3D-FH14370

H-Hyp-OH

CAS: 51-35-4

M03214 - H-Hyp-OH

Formula: C₅H₉NO₃

Purity: 97%

Color and Shape: Off-white crystalline powder

Molecular weight: 131.131

Ref: 10-M03214

L-Hydroxyproline extrapure CHR, 99%

CAS: 51-35-4

Formula: C₅H₉NO₃

Purity: min. 99.0%

Color and Shape: White to off white, Crystalline powder, Clear, Colourless to Pale yellow

Molecular weight: 131.13

Ref: SR-26921

trans-4-Hydroxy-L-proline-d6

Controlled Product

CAS: 51-35-4

Formula: C₅D₆H₃NO₃

Color and Shape: Neat

Molecular weight: 137.167

Ref: TR-H952374