CAS 51-48-9

(-)-Thyroxine

Description:

(-)-Thyroxine, also known as L-thyroxine or T4, is a hormone produced by the thyroid gland that plays a crucial role in regulating metabolism, growth, and development in the body. It is a tetraiodinated derivative of the amino acid tyrosine, characterized by the presence of four iodine atoms in its structure. The chemical formula for (-)-Thyroxine is C15H11I4N0, and it has a molecular weight of approximately 776.87 g/mol. This compound is typically found as a white to off-white crystalline powder and is soluble in water and alcohol but less soluble in organic solvents. (-)-Thyroxine functions by binding to thyroid hormone receptors, influencing gene expression and metabolic processes. It is commonly used in clinical settings to treat hypothyroidism and other thyroid-related disorders. Its activity is closely monitored, as both deficiency and excess can lead to significant health issues. The CAS number 51-48-9 uniquely identifies this compound in chemical databases, facilitating research and regulatory compliance.

Formula: C₁₅H₁₁I₄NO₄

InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key: InChIKey=XUIIKFGFIJCVMT-LBPRGKRZSA-N

SMILES: O(C1=CC(I)=C(O)C(I)=C1)C2=C(I)C=C(C[C@@H](C(O)=O)N)C=C2I

Synonyms:

• (-)-Thyroxine
• 3,3',5,5'-Tetraiodo-L-thyronine
• 3,3′,5,5′-Tetraiodo-<span class="text-smallcaps">L</span>-thyronine
• 3,5,3',5'-Tetraiodothyronine
• 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-alanine
• <span class="text-smallcaps">L</span>-T₄
• <span class="text-smallcaps">L</span>-Thyroxin
• <span class="text-smallcaps">L</span>-Thyroxine
• <span class="text-smallcaps">L</span>-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
• Beta-[(3,5-Diiodo-4-Hydroxyphenoxy)-3,5-Diiodophenyl]Alanine
• DL-thyroxin
• DL-thyroxine
• DL-tiroxina
• Henning
• L-3,5,3',5'-Tetraiodothyronine
• L-T4
• L-Thyroxin
• L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
• Levothyroxine
• Levotiron
• Nsc 36397
• O-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodo-L-Tyrosin
• O-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodotyrosine
• O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-<span class="text-smallcaps">L</span>-tyrosine
• O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
• SK&amp;F 1-6528
• T4
• T4(Hormone)
• T₄
• T₄ (hormone)
• THX
• Tetraiodothyronine
• Thyrax
• Thyreoideum
• Thyroxin
• Thyroxinal
• Thyroxine, <span class="text-smallcaps">L</span>-

Levothyroxine

CAS: 51-48-9

Amino-acid derivatives

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: Yellow Off-White Crystalline Powder

Molecular weight: 776.6867

Ref: 45-1365000

L-Thyroxine Sodium Salt Pentahydrate

CAS: 51-48-9, 55-03-8, 6106-07-6

Formula: C₁₅H₁₀I₄NNaO₄·5H₂O

Purity: >98.0%(T)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 888.94

Ref: 3B-T0245

L-Thyroxine, 98%

CAS: 51-48-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₅H₁₁I₄NO₄

Purity: 98%

Color and Shape: Powder, Pale cream to cream

Molecular weight: 776.87

Ref: 02-J62606

Liothyronine EP Impurity A

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Molecular weight: 776.9

Ref: ST-EA-CP-L45001

L-Thyroxine-[l-tyr-ring-13c6] hydrochloride

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Purity: 97%

Color and Shape: Liquid

Molecular weight: 776.8700

Ref: IN-DA0038OW

L-Thyroxine

CAS: 51-48-9

L-Thyroxine, major thyroid hormone, is made by iodinating tyrosine and coupling it in thyroglobulin, then secreted into blood.

Formula: C₁₅H₁₁I₄NO₄

Purity: 97.63% - 99.562%

Color and Shape: Crystals Solid

Molecular weight: 776.87

Ref: TM-T0864

L-Thyroxine

CAS: 51-48-9

L-Thyroxine

Purity: 97%

Molecular weight: 776.87g/mol

Ref: 54-OR1030066

L-Thyroxine

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 776.87

Ref: 7W-GP9966

L-Thyroxine (Tetraiodothyronine)

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: White To Off-White Solid

Molecular weight: 776.87

Ref: 4Z-T-421

L-Thyroxine

CAS: 51-48-9

L-Thyroxine

Purity: ≥95%

Molecular weight: 776.87g/mol

Ref: 54-BUP17744

L-Thyroxine

Controlled Product

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: Neat

Molecular weight: 776.87

Ref: 04-C17575300

Thyroxine (100% pure T4 reference standard (free of T3))

CAS: 51-48-9

Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: Off-White

Molecular weight: 776.87

Ref: TR-T425650

Thyroxine

Controlled Product

CAS: 51-48-9

Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: Off-White

Molecular weight: 776.87

Ref: TR-T425600

Levothyroxine Lactose Adduct >85%

Controlled Product

CAS: 51-48-9

Formula: C₂₇H₃₁I₄NO₁₄

Purity: >85%

Color and Shape: Neat

Molecular weight: 1101.151

Ref: TR-L378053

O-(4-HYDROXY-3,5-DIIODOPHENYL)-3,5-DIIODO-L-TYROSINE

CAS: 51-48-9

Purity: 97%

Molecular weight: 776.8740234

Ref: 10-F837420

2-(3-(4-Hydroxy-3,5-diiodophenoxy)-2,4-diiodobenzamido)-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid, Amide-Bridged

Controlled Product

CAS: 51-48-9

Formula: C₂₈H₁₆I₇NO₇

Color and Shape: Neat

Molecular weight: 1366.76

Ref: TR-H972213

Levothyroxine

CAS: 51-48-9

Levothyroxine is a thyroid hormone that is used to treat hypothyroidism. It is taken in tablet form, usually once per day. Levothyroxine therapy can be started with a low dose and increased gradually over time. This drug has been shown to be effective in the treatment of bowel disease, which may be due to its ability to decrease inflammation and increase the movement of stool through the intestines. Levothyroxine has also been shown to have beneficial effects on other autoimmune diseases such as rheumatoid arthritis and congestive heart failure. The use of levothyroxine requires periodic blood sampling for monitoring.

Formula: C₁₅H₁₁I₄NO₄

Purity: Min. 98 Area-%

Color and Shape: Off-White Powder

Molecular weight: 776.87 g/mol

Ref: 3D-FL34087

L-Thyroxine-13C6

CAS: 51-48-9

Formula: C₉₁₃C₆H₁₁I₄NO₄

Molecular weight: 782.83

Ref: 4Z-T-422