CAS 51-48-9

(-)-Thyroxine

Description:

(-)-Thyroxine, also known as L-thyroxine or T4, is a hormone produced by the thyroid gland that plays a crucial role in regulating metabolism, growth, and development in the body. It is a tetraiodinated derivative of the amino acid tyrosine, characterized by the presence of four iodine atoms in its structure. The chemical formula for (-)-Thyroxine is C15H11I4N0, and it has a molecular weight of approximately 776.87 g/mol. This compound is typically found as a white to off-white crystalline powder and is soluble in water and alcohol but less soluble in organic solvents. (-)-Thyroxine functions by binding to thyroid hormone receptors, influencing gene expression and metabolic processes. It is commonly used in clinical settings to treat hypothyroidism and other thyroid-related disorders. Its activity is closely monitored, as both deficiency and excess can lead to significant health issues. The CAS number 51-48-9 uniquely identifies this compound in chemical databases, facilitating research and regulatory compliance.

Formula: C₁₅H₁₁I₄NO₄

InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key: InChIKey=XUIIKFGFIJCVMT-LBPRGKRZSA-N

SMILES: O(C1=CC(I)=C(O)C(I)=C1)C2=C(I)C=C(C[C@@H](C(O)=O)N)C=C2I

Synonyms:

• (-)-Thyroxine
• 3,3',5,5'-Tetraiodo-L-thyronine
• 3,3′,5,5′-Tetraiodo-<span class="text-smallcaps">L</span>-thyronine
• 3,5,3',5'-Tetraiodothyronine
• 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-alanine
• <span class="text-smallcaps">L</span>-T₄
• <span class="text-smallcaps">L</span>-Thyroxin
• <span class="text-smallcaps">L</span>-Thyroxine
• <span class="text-smallcaps">L</span>-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
• Beta-[(3,5-Diiodo-4-Hydroxyphenoxy)-3,5-Diiodophenyl]Alanine
• DL-thyroxin
• DL-thyroxine
• DL-tiroxina
• Henning
• L-3,5,3',5'-Tetraiodothyronine
• L-T4
• L-Thyroxin
• L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
• Levothyroxine
• Levotiron
• Nsc 36397
• O-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodo-L-Tyrosin
• O-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodotyrosine
• O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-<span class="text-smallcaps">L</span>-tyrosine
• O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
• SK&amp;F 1-6528
• T4
• T4(Hormone)
• T₄
• T₄ (hormone)
• THX
• Tetraiodothyronine
• Thyrax
• Thyreoideum
• Thyroxin
• Thyroxinal
• Thyroxine, <span class="text-smallcaps">L</span>-

Levothyroxine

CAS: 51-48-9

Amino-acid derivatives

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: Yellow Off-White Crystalline Powder

Molecular weight: 776.6867

Ref: 45-1365000

L-Thyroxine Sodium Salt Pentahydrate

CAS: 51-48-9, 55-03-8, 6106-07-6

Formula: C₁₅H₁₀I₄NNaO₄·5H₂O

Purity: >98.0%(T)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 888.94

Ref: 3B-T0245

L-Thyroxine, 98%

CAS: 51-48-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₅H₁₁I₄NO₄

Purity: 98%

Color and Shape: Powder, Pale cream to cream

Molecular weight: 776.87

Ref: 02-J62606

L-Thyroxine

CAS: 51-48-9

L-Thyroxine

Formula: C₁₅H₁₁I₄NO₄

Purity: >97%

Color and Shape: Solid

Molecular weight: 776.87

Ref: 54-OR1030066

L-Thyroxine

CAS: 51-48-9

L-Thyroxine

Formula: C₁₅H₁₁I₄NO₄

Purity: ≥95%

Molecular weight: 776.87

Ref: 54-BUP17744

L-Thyroxine

CAS: 51-48-9

L-Thyroxine, major thyroid hormone, is made by iodinating tyrosine and coupling it in thyroglobulin, then secreted into blood.

Formula: C₁₅H₁₁I₄NO₄

Purity: 97.63% - 99.56%

Color and Shape: Crystals Solid

Molecular weight: 776.87

Ref: TM-T0864

L-Thyroxine-[l-tyr-ring-13c6] hydrochloride

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Purity: 97%

Color and Shape: Liquid

Molecular weight: 776.8700

Ref: IN-DA0038OW

L-Thyroxine (Liothyronine EP Impurity A, Levothyroxine, Tetraiodothyronine)

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: White To Off-White Solid

Molecular weight: 776.87

Ref: 4Z-T-421

L-Thyroxine

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 776.87

Ref: 7W-GP9966

L-Thyroxine

Controlled Product

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: White To Light Beige

Molecular weight: 776.87

Ref: 04-C17575300

L-Thyroxine (Standard)

CAS: 51-48-9

L-Thyroxine (Standard) is the standard substance of L-Thyroxine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. L-Thyroxine (NSC 36397) is released from thyroglobulin by proteolysis and secreted into the blood. L-Thyroxine (NSC 36397) is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: Solid

Molecular weight: 776.87

Ref: TM-TMSM-1492

Levothyroxine

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Molecular weight: 776.87

Ref: ST-EA-CP-L18000

Levothyroxine Lactose Adduct >85%

Controlled Product

CAS: 51-48-9

Formula: C₂₇H₃₁I₄NO₁₄

Purity: >85%

Color and Shape: Neat

Molecular weight: 1101.151

Ref: TR-L378053

Thyroxine

Controlled Product

CAS: 51-48-9

Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: Neat

Molecular weight: 776.87

Ref: TR-T425600

Thyroxine (100% pure T4 reference standard (free of T3))

CAS: 51-48-9

Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);

Formula: C₁₅H₁₁I₄NO₄

Color and Shape: Neat

Molecular weight: 776.87

Ref: TR-T425650

Liothyronine EP Impurity A

CAS: 51-48-9

Formula: C₁₅H₁₁I₄NO₄

Molecular weight: 776.9

Ref: ST-EA-CP-L45001

L-Thyroxine-[13C6] Hydrochloride(T4)

CAS: 51-48-9

Ref: BE-MC-2535C6

L-Thyroxine-[13C6] Hydrochloride(T4) in Methanol

CAS: 51-48-9

Methanol

Ref: BE-MC-2535C6XM-100

O-(4-HYDROXY-3,5-DIIODOPHENYL)-3,5-DIIODO-L-TYROSINE

CAS: 51-48-9

Purity: 97%

Molecular weight: 776.8740234

Ref: 10-F837420

2-(3-(4-Hydroxy-3,5-diiodophenoxy)-2,4-diiodobenzamido)-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic Acid, Amide-Bridged

Controlled Product

CAS: 51-48-9

Formula: C₂₈H₁₆I₇NO₇

Color and Shape: Neat

Molecular weight: 1366.76

Ref: TR-H972213