CAS 51014-29-0

Isocorynoxeine

Description:

Isocorynoxeine is a naturally occurring alkaloid primarily derived from certain plant species, particularly those in the genus Uncaria, commonly known as cat's claw. It is characterized by its complex molecular structure, which includes multiple rings and functional groups that contribute to its biological activity. Isocorynoxeine has garnered interest in pharmacology due to its potential therapeutic properties, including anti-inflammatory, antioxidant, and neuroprotective effects. The compound exhibits a moderate level of solubility in organic solvents, while its solubility in water is limited. Its mechanism of action is thought to involve modulation of various biochemical pathways, although further research is needed to fully elucidate its effects and potential applications in medicine. As with many alkaloids, caution is advised regarding its use, as it may exhibit toxicity at higher concentrations or in sensitive individuals. Overall, Isocorynoxeine represents a fascinating subject of study within the field of natural products and medicinal chemistry.

Formula: C₂₂H₂₆N₂O₄

InChI: InChI=1/C22H26N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h4-8,13-15,19H,1,9-12H2,2-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22-/m0/s1

InChI key: InChIKey=MUVGVMUWMAGNSY-VKCGGMIFSA-N

SMILES: O=C1[C@]2([C@]3(N(CC2)C[C@H](C=C)[C@@H](\C(\C(OC)=O)=C/OC)C3)[H])C=4C(N1)=CC=CC4

Synonyms:

• 7-Isocorynoxeine
• Corynoxan-16-carboxylic acid, 16,17,18,19-tetradehydro-17-methoxy-2-oxo-, methyl ester, (16E,20α)-
• Isocorynoxeine
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethenyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1′S,6′R,7′S,8′aS)-
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethenyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, [1′S-[1′α,6′α,7′β(E),8′aα]]-
• methyl (16E,20alpha)-16-(methoxymethylidene)-2-oxocorynox-18-en-17-oate
• Isocorynoxeine, BR
• Isocorynoxeine (7-Isocorynoxeine)
• Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-
• Isocorynoxeine USP/EP/BP
• methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
• (alphaE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester

Isocorynoxeine

CAS: 51014-29-0

Formula: C₂₂H₂₆N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 382.4528

Ref: IN-DA00DB8T

Isocorynoxeine

CAS: 51014-29-0

Isocorynoxeine

Purity: ≥98%

Molecular weight: 382.45g/mol

Ref: 54-BUP00201

Isocorynoxeine

CAS: 51014-29-0

Formula: C₂₂H₂₆N₂O₄

Molecular weight: 382.46

Ref: 7W-GY4429

Isocorynoxeine

CAS: 51014-29-0

Isocorynoxeine, an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. Isocorynoxeine shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage, it exhibits a significant neuroprotective effect against glutamate-induced HT22 cell death at the maximum concentration.

Formula: C₂₂H₂₆N₂O₄

Purity: 95%~99%

Molecular weight: 382.46

Ref: BP-BP0778

Isocorynoxeine

CAS: 51014-29-0

Isocorynoxeine reduces blood pressure, dilates vessels, and guards neurons against ischemia and glutamate toxicity.

Formula: C₂₂H₂₆N₂O₄

Purity: 98% - 99.9%

Color and Shape: Solid

Molecular weight: 382.45

Ref: TM-T6S0654