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CAS 51022-71-0

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Nabilone

Description:
Nabilone is a synthetic cannabinoid that mimics the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. It is primarily used as an antiemetic to treat nausea and vomiting associated with chemotherapy in cancer patients. Nabilone acts on the cannabinoid receptors in the brain, influencing neurotransmitter release and providing relief from symptoms. The substance is characterized by its chemical structure, which includes a bicyclic structure and a series of functional groups that contribute to its pharmacological activity. Nabilone is typically administered in capsule form and has a relatively long half-life, allowing for sustained therapeutic effects. Common side effects may include dizziness, dry mouth, and alterations in mood or perception. Due to its psychoactive properties, nabilone is classified as a controlled substance in many jurisdictions, necessitating careful regulation and monitoring in clinical use. Its efficacy and safety profile have made it a valuable option in the management of chemotherapy-induced nausea and vomiting, particularly for patients who do not respond to conventional treatments.
Formula:C24H36O3
InChI:InChI=1/C24H36O3/c1-6-7-8-9-12-23(2,3)16-13-20(26)22-18-15-17(25)10-11-19(18)24(4,5)27-21(22)14-16/h13-14,18-19,26H,6-12,15H2,1-5H3/t18-,19-/s2
InChI key:InChIKey=GECBBEABIDMGGL-PVIFGLDDNA-N
SMILES:OC1=C2[C@]3([C@](C(C)(C)OC2=CC(C(CCCCCC)(C)C)=C1)(CCC(=O)C3)[H])[H]
Synonyms:
  • (±)-trans-3-(1,1-Dimethylheptyl)-7,8,10,10α-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo-[b,d]pyran-9(6αH)one
  • 9H-Dibenzo[b,d]pyran-9-one, 3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-, trans-
  • Canemes
  • Cesamet
  • Compd. 109514
  • Lilly 109514
  • Ly 109514
  • Nabilone
  • rel-(6aR,10aR)-3-(1,1-Dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one
  • trans-Nabilone
  • See more synonyms
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Found 3 products.
  • Nabilone
    TRC
    + Info

    Nabilone

    Controlled Product
    CAS:
    <p>Applications A synthetic cannabinoid with antiemetic, antiglaucoma, and CNS activity. Antiemetic. Controlled substance (hallucinogen). Synthetic Cannabinoids<br>References Rubin, A., et al.: Clin. Pharmacol. Ther., 22, 85 (1977), Stark, P., et al.: J. Pharmacol. Exp. Ther., 214, 124 (1980), Souter, R.W., et al.: Anal. Profiles Drug Subs., 10, 499 (1981), Ward, A., Drugs, 30, 127 (1985),<br></p>
    Formula:C24H36O3
    Color and Shape:Off White Crystalline Powder
    Molecular weight:372.54

    Ref: TR-N200000

    5mg
    375.00€
    25mg
    1,438.00€
    50mg
    2,425.00€
  • Nabilone (1 mg/mL in Acetonitrile)
    TRC
    + Info

    Nabilone (1 mg/mL in Acetonitrile)

    Controlled Product
    CAS:
    Formula:C24H36O3
    Color and Shape:Single Solution
    Molecular weight:372.54

    Ref: TR-KIT0320

    5x1ml
    1,027.00€
  • Nabilone
    Biosynth
    + Info

    Nabilone

    Controlled Product
    CAS:
    <p>Nabilone is a dibenzopyrane-derived synthetic cannabinoid with agonist activity at the cannabinoid receptor CB1 and CB2 (Ki= 2.2 and 1.8 nM, respectively)1. In vitro studies showed that nabilone induces greater cAMP inhibition and GTPyS binding when compared to Δ9-THC in mouse brain tissue2. In vivo studies showed no genotoxicity in bacteria, rat hepatocyte cell lines, rat micronucleus test, and Chinese hamster bone marrow. Further, in vivo studies on experimental animal models showed a good safety profile in rats and monkeys, but fatal toxicity in canine models. Nabilone was shown to promote activation of CB2 receptor-mediated anti-inflammatory effects in experimental mice models3.</p>
    Formula:C24H36O3
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:372.54 g/mol

    Ref: 3D-FN126318

    1mg
    382.00€
    5mg
    719.00€
    10mg
    1,193.00€