CAS 51022-77-6

Etazolate

Description:

Etazolate, with the CAS number 51022-77-6, is a chemical compound that belongs to the class of benzodiazepines. It is primarily recognized for its anxiolytic and sedative properties, making it relevant in the field of pharmacology, particularly in the treatment of anxiety disorders. The compound exhibits a mechanism of action that involves modulation of the gamma-aminobutyric acid (GABA) receptor, enhancing the inhibitory effects of GABA in the central nervous system. Etazolate is characterized by its relatively high lipophilicity, which influences its absorption and distribution in biological systems. Additionally, it has a moderate half-life, allowing for effective therapeutic dosing regimens. The compound is typically administered orally and has been studied for its potential neuroprotective effects. However, like many benzodiazepines, it may carry risks of dependence and withdrawal symptoms with prolonged use. Overall, etazolate represents a significant interest in both clinical and research settings for its therapeutic applications and pharmacological profile.

Formula: C₁₄H₁₉N₅O₂

InChI: InChI=1S/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18)

InChI key: InChIKey=OPQRBXUBWHDHPQ-UHFFFAOYSA-N

SMILES: N(N=C(C)C)C1=C2C(N(CC)N=C2)=NC=C1C(OCC)=O

Synonyms:

• 1-Ethyl-4-(N′-isopropylidene-hydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester
• 1-Ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]-1-pyridine-5-carboxylic acid ethyl ester
• 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester
• 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 1-ethyl-4-[2-(1-methylethylidene)hydrazinyl]-, ethyl ester
• Etazolate [INN]
• Etazolato
• Etazolato [INN-Spanish]
• Etazolatum
• Etazolatum [INN-Latin]
• Sq 64442
• Unii-I89Y79062L
• ethyl 1-ethyl-4-[2-(propan-2-ylidene)hydrazinyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Etazolate

Controlled Product

CAS: 51022-77-6

Applications An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.
References Chesin, et al.: Biochem. Pharmacol., 21, 2443 (1972), Ahluwalia, et al.: Biochem. Pharmacol., 31, 665 (1982), Nicholson, et al.: TIPS, 12, 19 (1991),

Formula: C₁₄H₁₉N₅O₂

Color and Shape: Neat

Molecular weight: 289.33

Ref: TR-E889250

Etazolate

CAS: 51022-77-6

Etazolate is an ester hydrochloride that inhibits the activity of cyclic nucleotide phosphodiesterases, which are enzymes that degrade cyclic nucleotides. It is used to treat bowel diseases and physiological effects in rats. Etazolate has also been shown to increase the mitochondrial membrane potential, energy metabolism, and blood flow in rat hearts. Additionally, it has been shown to inhibit neuronal death and induce neurotrophic factors in rats with Parkinson's disease. Etazolate has a model system that includes pharmacological treatment and blood sampling in mice.

Formula: C₁₄H₁₉N₅O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 289.33 g/mol

Ref: 3D-FE22846

Etazolate

CAS: 51022-77-6

Etazolate is an inhibitor of phosphodiesterase IV that is about 8 times more active for cAMP than cGMP.

Formula: C₁₄H₁₉N₅O₂

Color and Shape: Solid

Molecular weight: 289.33

Ref: TM-T69171