CAS 5116-24-5

5-Hydroxymethyl-2′-deoxyuridine

Description:

5-Hydroxymethyl-2′-deoxyuridine (HMdU) is a nucleoside analog of deoxyuridine, characterized by the presence of a hydroxymethyl group at the 5-position of the uracil base. Its chemical formula is C10H13N2O5, and it has a molecular weight of approximately 241.23 g/mol. HMdU is notable for its role in biochemical research, particularly in studies related to DNA synthesis and repair mechanisms. It can be incorporated into DNA during replication, potentially affecting the stability and function of the genetic material. The compound is often used in the context of studying the effects of modified nucleosides on cellular processes and has implications in cancer research and antiviral therapies. HMdU is typically soluble in water and exhibits moderate stability under physiological conditions. Its CAS number, 5116-24-5, is a unique identifier that facilitates its recognition in scientific literature and databases. Overall, HMdU serves as a valuable tool in molecular biology and medicinal chemistry for understanding nucleic acid behavior and interactions.

Formula: C₁₀H₁₄N₂O₆

InChI: InChI=1S/C10H14N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2,6-8,13-15H,1,3-4H2,(H,11,16,17)/t6-,7+,8+/m0/s1

InChI key: InChIKey=IPAVKOYJGUMINP-XLPZGREQSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(CO)C(=O)N1

Synonyms:

• 1-(2-deoxypentofuranosyl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
• 2'-Deoxy-5-(Hydroxymethyl)Uridine
• 2′-Desoxy-5-hydroxymethyluridine
• 5-(Hydroxymethyl)-2′-desoxyuridine
• 5-Hydroxymethyldeoxyuridine
• Thymidine, α-hydroxy-
• Uridine, 2′-deoxy-5-(hydroxymethyl)-
• α-Hydroxythymidine
• 5-Hydroxymethyl-2′-deoxyuridine

5-Hydroxymethyl-2'-deoxyuridine

CAS: 5116-24-5

Formula: C₁₀H₁₄N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 258.2280

Ref: IN-DA00D9ZJ

2''-Deoxy-5-hydroxymethyluridine

CAS: 5116-24-5

Formula: C₁₀H₁₄N₂O₆

Molecular weight: 258.23

Ref: 7W-GN8176

5-Hydroxymethyl-2'-deoxyuridine

CAS: 5116-24-5

5-Hydroxymethyl-2'-deoxyuridine

Formula: C₁₀H₁₄N₂O₆

Purity: 98%

Color and Shape: white solid

Molecular weight: 258.23g/mol

Ref: 54-OR917202

5-Hydroxymethyldeoxyuridine

CAS: 5116-24-5

5-Hydroxymethyldeoxyuridine

Purity: ≥98%

Molecular weight: 258.23g/mol

Ref: 54-BUP11105

2'-Deoxy-5-(hydroxymethyl)uridine

CAS: 5116-24-5

Formula: C₁₀H₁₄N₂O₆

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 258.23

Ref: 3B-D6190

5-Hydroxymethyldeoxyuridine

CAS: 5116-24-5

5-Hydroxymethyldeoxyuridine: anticancer/antiviral; inhibits S180 and Ehrlich cells (ED50=8.5/4 μM) & leukemia lines (IC50=1.7-5.8 μM).

Formula: C₁₀H₁₄N₂O₆

Purity: 99.80%

Color and Shape: Solid

Molecular weight: 258.23

Ref: TM-T8695

5-Hydroxymethyl-2’-deoxyuridine

Controlled Product

CAS: 5116-24-5

Stability Hygroscopic
Applications 5-Hydroxymethyl-2’-deoxyuridine acts as a biomarker for the diagnosis for oxidative stress in humans. Used as a diagnostic to for propensitiy for the development of breast cancer.
References McAnulty, L. et al.: App. Physiol. Nutr. Metab., 36, 976 (2011); Djuric Z. et al.: Cancer Epidemiol. Biomarkers. Prev., 10, 147 (2001); Frenkel, K. et al.: 7, 49, (1998);

Formula: C₁₀H₁₄N₂O₆

Color and Shape: White To Off-White

Molecular weight: 258.228

Ref: TR-H962300

2'-Deoxy-5-hydroxymethyluridine

CAS: 5116-24-5

2'-Deoxy-5-hydroxymethyluridine (DHMU) is a natural compound that has been shown to have inhibitory properties against bowel disease. DHMU inhibits the proliferation of wild-type strains of Salmonella enterica serovar Typhimurium and Escherichia coli by binding to their nuclear dna. It also prevents DNA synthesis in human polymorphonuclear leukocytes and synergizes with pharmacological agents, such as radiation or chemotherapeutic agents, to induce cell death. This agent can be used as an analytical method for the detection of nucleic acids.

Formula: C₁₀H₁₄N₂O₆

Purity: Min. 98.0 Area-%

Color and Shape: White Powder

Molecular weight: 258.23 g/mol

Ref: 3D-ND08018

5-Hydroxymethyl-2′-deoxyuridine

CAS: 5116-24-5

Purity: 98%

Molecular weight: 258.230

Ref: 10-F866543