CAS 51165-09-4

substance P fragment 5-11

Description:

Substance P fragment 5-11, with the CAS number 51165-09-4, is a peptide derived from substance P, a neuropeptide involved in pain perception and inflammatory processes. This fragment consists of a specific sequence of amino acids, typically comprising seven residues, which contributes to its biological activity. Characteristically, it exhibits properties associated with neurokinin receptors, particularly the neurokinin-1 receptor, which mediates various physiological responses, including pain transmission and modulation of mood. The fragment is often studied for its role in neurobiology and potential therapeutic applications, particularly in pain management and neuroinflammatory conditions. Its solubility and stability can vary depending on the formulation and conditions, such as pH and temperature. Additionally, like many peptides, it may be susceptible to enzymatic degradation, which can influence its bioavailability and efficacy in biological systems. Overall, substance P fragment 5-11 serves as a valuable tool in research aimed at understanding the complex mechanisms of pain and neurogenic inflammation.

Formula: C₄₁H₆₀N₁₀O₉S

InChI: InChI=1/C41H60N10O9S/c1-24(2)20-30(40(59)48-28(36(45)55)18-19-61-3)47-35(54)23-46-38(57)31(21-25-10-6-4-7-11-25)50-41(60)32(22-26-12-8-5-9-13-26)51-39(58)29(15-17-34(44)53)49-37(56)27(42)14-16-33(43)52/h4-13,24,27-32H,14-23,42H2,1-3H3,(H2,43,52)(H2,44,53)(H2,45,55)(H,46,57)(H,47,54)(H,48,59)(H,49,56)(H,50,60)(H,51,58)/t27-,28-,29-,30-,31-,32-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCSC)C(=N)O)O)N=C(CN=C([C@H](Cc1ccccc1)N=C([C@H](Cc1ccccc1)N=C([C@H](CCC(=N)O)N=C([C@H](CCC(=N)O)N)O)O)O)O)O

Synonyms:

• Substance P (5-11)
• 1-Dearginyl-2,4-deprolyl-3-delysine-substance P
• 1-Des-arg-2,4-des-pro-3-des-lys-substance P
• Spcthp
• Substance P C-terminal heptapeptide
• Substance P, dearginyl(1)-deprolyl(2,4)-delysine(3)-
• Substance P, 1-de-L-arginine-2-de-L-proline-3-de-L-lysine-4-de-L-proline-
• L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide

Substance P (5-11)

CAS: 51165-09-4

Bachem ID: 4039865.

Formula: C₄₁H₆₀N₁₀O₉S

Purity: > 94%

Color and Shape: White

Molecular weight: 869.06

Ref: 01-4039865

Substance P (5-11)/Hepta-Substance P

CAS: 51165-09-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₄₁H₆₀N₁₀O₉S

Molecular weight: 869.06 g/mol

Ref: 3D-PP50605

Substance P (5-11) trifluoroacetate salt

CAS: 51165-09-4

Substance P is a bifunctional neuropeptide that acts as both a neurotransmitter and a neurohormone. The amino acid sequence of Substance P is H-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. It is found in the brain and spinal cord, but also in other tissues such as the parotid gland and stomach. This peptide is released from nerve cells when they are stimulated by pain or anxiety, and it causes contraction of smooth muscles in the lungs, uterus, and gastrointestinal tract. Animal studies have shown that Substance P can be toxic to neonatal animals, leading to hypothyroidism and death. In vitro studies have shown that this peptide can induce the growth of glioma cells and tumors.

Formula: C₄₁H₆₀N₁₀O₉S

Purity: Min. 95%

Molecular weight: 869.04 g/mol

Ref: 3D-FS109598