CAS 5119-48-2: Withaferin A
Description:Withaferin A is a naturally occurring steroidal lactone derived from the Withania somnifera plant, commonly known as ashwagandha. It is classified as a withanolide, which is a type of compound known for its diverse biological activities. Withaferin A exhibits a range of pharmacological properties, including anti-inflammatory, anti-cancer, and neuroprotective effects. Its mechanism of action involves the modulation of various signaling pathways, including the inhibition of nuclear factor kappa B (NF-κB) and the induction of apoptosis in cancer cells. The compound is also noted for its potential to enhance the immune response and exhibit antioxidant properties. Withaferin A is typically studied in the context of traditional medicine and modern pharmacology, and its therapeutic potential is being explored in various diseases, including cancer and neurodegenerative disorders. However, further research is necessary to fully understand its efficacy and safety in clinical applications.
Formula:C28H38O6
InChI:InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
InChI key:InChIKey=DBRXOUCRJQVYJQ-CKNDUULBSA-N
SMILES:O=C1OC(CC(=C1CO)C)C(C)C2CCC3C4CC5OC65C(O)C=CC(=O)C6(C)C4CCC23C
- Synonyms:
- (4b,5b,6b,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone
- 4b,27-Dihydroxy-1-oxo-5b,6b-epoxywitha-2,24-dienolide
- 5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone
- 5,6-Epoxy-5H-cyclopenta[a]phenanthrene, ergosta-2,24-dien-26-oic acid deriv.
- 5β-Ergosta-2,24-dien-26-oic acid, 5,6β-epoxy-4β,22,27-trihydroxy-1-oxo-, δ-lactone, (20S,22R)-
- Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, δ-lactone, (4β,5β,6β,22R)-
- NSC 101088
- NSC 273757
- Withaferin A
- Withaferine
- See more synonyms
- Withaferine A