CAS 5119-48-2

Withaferin A

Description:

Withaferin A is a naturally occurring steroidal lactone derived from the Withania somnifera plant, commonly known as ashwagandha. It is classified as a withanolide, which is a type of compound known for its diverse biological activities. Withaferin A exhibits a range of pharmacological properties, including anti-inflammatory, anti-cancer, and neuroprotective effects. Its mechanism of action involves the modulation of various signaling pathways, including the inhibition of nuclear factor kappa B (NF-κB) and the induction of apoptosis in cancer cells. The compound is also noted for its potential to enhance the immune response and exhibit antioxidant properties. Withaferin A is typically studied in the context of traditional medicine and modern pharmacology, and its therapeutic potential is being explored in various diseases, including cancer and neurodegenerative disorders. However, further research is necessary to fully understand its efficacy and safety in clinical applications.

Formula: C₂₈H₃₈O₆

InChI: InChI=1/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1

InChI key: InChIKey=DBRXOUCRJQVYJQ-CKNDUULBSA-N

SMILES: C[C@]12[C@]3([C@](O3)(C[C@@]4([C@@]1(CC[C@@]5(C)[C@]4(CC[C@@]5([C@H](C)[C@]6(CC(C)=C(CO)C(=O)O6)[H])[H])[H])[H])[H])[H])[C@@H](O)C=CC2=O

Synonyms:

• (4b,5b,6b,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone
• 4b,27-Dihydroxy-1-oxo-5b,6b-epoxywitha-2,24-dienolide
• 5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone
• 5,6-Epoxy-5H-cyclopenta[a]phenanthrene, ergosta-2,24-dien-26-oic acid deriv.
• 5β-Ergosta-2,24-dien-26-oic acid, 5,6β-epoxy-4β,22,27-trihydroxy-1-oxo-, δ-lactone, (20S,22R)-
• Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, δ-lactone, (4β,5β,6β,22R)-
• NSC 101088
• NSC 273757
• Withaferin A
• Withaferine
• Withaferine A
• withaferinea
• Withaferin A NSC 273757 NSC 101088
• Withaferin A from leaves of Withania somnifera
• 2,24-dien-26-oic Acid δ-Lactone
• 5,6-beta-epoxy-4-beta,22,27-trihydroxy-1-5-beta-ergosta-24-dien-26-oicacid
• (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone
• (20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta-
• Withaferin A 5119-48-2
• 5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
• Withaferin A Standard
• Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem
• Ergosta-2,24-dien-26-oicacid, 5,6-epoxy-4,22,27-trihydroxy-1-oxo-, d-lactone, (4b,5b,6b,22R)-

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 470.5977

Ref: IN-DA00DCXC

WITHAFERIN A

CAS: 5119-48-2

WITHAFERIN A

Purity: ≥95%

Molecular weight: 470.6g/mol

Ref: 54-BUP12713

Withaferin A

CAS: 5119-48-2

Withaferin A

Formula: C₂₈H₃₈O₆

Purity: By hplc: 99.01% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 470.60g/mol

Ref: 54-BIW4202

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Color and Shape: Neat

Molecular weight: 470.60

Ref: 04-C17942200

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Purity: 95%~99%

Molecular weight: 470.606

Ref: BP-BP4186

WITHAFERIN A

CAS: 5119-48-2

WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/

Formula: C₂₈H₃₈O₆

Purity: 97.41% - 99.99%

Color and Shape: Solid

Molecular weight: 470.60

Ref: TM-T5687

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Purity: ≥ 95.0%

Color and Shape: White to light yellow powder

Molecular weight: 470.61

Ref: 7W-GY6190

Withaferin A

CAS: 5119-48-2

Formula: C₂₈H₃₈O₆

Molecular weight: 470.61

Ref: 4Z-W-011001

Withaferin a

CAS: 5119-48-2

Lactone

Formula: C₂₈H₃₈O₆

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 470.61

Ref: 5G-89824

Withaferin A

CAS: 5119-48-2

Withaferin A is a bioactive compound, which is a steroidal lactone with antiproliferative properties. It is derived from the medicinal plant *Withania somnifera*, commonly known as Ashwagandha. Withaferin A exerts its effects by modulating various signaling pathways, including the inhibition of NF-kB and induction of oxidative stress, which lead to apoptotic cell death in cancer cells and reduced inflammation.

Formula: C₂₈H₃₈O₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 470.6 g/mol

Ref: 3D-FW32226

Withaferin A

CAS: 5119-48-2

Applications Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).
References Shohat, B., et al.: Cancer Chemother. Rep., 51, 271 (1967), Shohat, B., et al.: Int. J. Cancer., 8, 487 (1971); Chem. and Eng. News p. 6, Aug. 8, 2016

Formula: C₂₈H₃₈O₆

Color and Shape: White Solid

Molecular weight: 470.60

Ref: TR-W499200

Deuterated Withaferin A Deuterated

Controlled Product

CAS: 5119-48-2

Formula: C₂₈H₃₅D₃O₆

Color and Shape: Neat

Molecular weight: 470.60 (Unlabelled)

Ref: TR-W499202