CAS 51239-26-0

8-(4-chlorophenylthio)guanosine*3':5'-cyclic mono

Description:

8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphate, commonly referred to as a cyclic nucleotide, is a derivative of guanosine that features a chlorophenylthio group at the 8-position of the guanine base. This modification can influence the molecule's biological activity and interaction with various enzymes and receptors. Cyclic nucleotides, including this compound, play crucial roles in cellular signaling pathways, particularly in the regulation of processes such as cell growth, differentiation, and apoptosis. The presence of the 4-chlorophenylthio group may enhance the compound's stability and affinity for specific targets, making it a valuable tool in biochemical research. Additionally, the cyclic monophosphate structure allows for the formation of a phosphodiester bond, which is essential for its function as a signaling molecule. Overall, this compound exemplifies the intricate relationship between molecular structure and biological activity in the realm of nucleotides and their derivatives.

Formula: C₁₆H₁₄ClN₅NaO₇PS

InChI: InChI=1/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1

SMILES: c1cc(ccc1Cl)Sc1nc2c([nH]c(=N)nc2O)n1C1C(C2C(COP(=O)(O)O2)O1)O.[Na]

Synonyms:

• 8-(4-chlorophenylthio)guanosine-3’,5’-cyclicmonophosphate(8-pcpt-cgmp),sodiumsalt
• 8-(4-chlorophenylthio)guanosine*3’:5’-cyclicmono
• 8-(4-Chlorophenylthio)-guanosine-3'',5''-cyclic monophosphoric acid sodium sa
• 8-pCPT-cGMP, pCPT-cGMP
• CGMP, 8-PCPT-, NA
• 8-PCPT-CGMP TEA
• pCPT-cGMP
• 8-(4-CHLOROPHENYLTHIO)GUANOSINE3':5'-CYC LIC MONOPH
• 8-(4-CHLOROPHENYLTHIO)GUANOSINE 3':5'-CYLIC MONOPHOSPHATE SODIUM SALT
• 8-(4-Chlorophenylthio)guanosine3&rsquo
• 8-PCPT-CGMP SODIUM SALT
• 8-PCPT-CGMP NA

8-(4-Chlorophenylthio)guanosine-3'',5''-cyclic monophosphate sodium salt

CAS: 51239-26-0

Formula: C₁₆H₁₄ClN₅NaO₇PS

Molecular weight: 509.79

Ref: 7W-GN1381

8-Pcpt-cGMP sodium

CAS: 51239-26-0

8-Pcpt-cGMP sodium, with an EC50 of 0.5 μM, acts as an agonist for cyclic nucleotide-gated (CNG) channels and demonstrates effective membrane permeability. This compound is utilized in research focused on the role of CNG channels in visual and olfactory signal transduction.

Formula: C₁₆H₁₄ClN₅NaO₇PS

Color and Shape: Solid

Molecular weight: 509.79

Ref: TM-T88142

8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphate sodium salt

CAS: 51239-26-0

8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphate sodium salt (8CPTcGMP) is a fluorescent compound that is used to study the localization of proteins in living cells. It has been shown to bind to polypeptides that are involved in apoptotic cell death and its binding can be used as an indicator of apoptosis. 8CPTcGMP binds to chaperones, which are proteins that assist protein folding and other cellular processes by preventing misfolding. Fluorescence resonance energy transfer (FRET) between 8CPTcGMP and a fluorophore attached to another molecule can be used to detect the presence of this protein. The genetic code for 8CPTcGMP is ACACTCA.

Formula: C₁₆H₁₄ClN₅O₇PS·Na

Purity: Min. 95%

Molecular weight: 509.79 g/mol

Ref: 3D-NC10430