CAS 51246-37-8

Ethacrynic Acid L-Cysteine Adduct

CAS: 51246-37-8

Formula: C₁₆H₁₉Cl₂NO₆S

Molecular weight: 424.29

Ref: 4Z-E-297

Ethacrynic Acid L-Cysteine Adduct

Controlled Product

CAS: 51246-37-8

Applications A metabolite of Ethacrynic Acid (E676000) that is a potent inhibitor of sodium-potassium-chloride cotransporter and bumetanide binding. Also an inhibitor of human hepatic glutathione S-transferase isozymes.
References Palfrey, H. et al.: Am. J. Physiol., 264, C1270 (1993); Klaassen, C.D. et al.: J. Pharmacol. Exp. Therap., 191, 548(1974); Takamatsu, Y. et al.: Toxicol. Lett., 62, 241 (1992);

Formula: C₁₆H₁₉Cl₂NO₆S

Color and Shape: Neat

Molecular weight: 424.3

Ref: TR-E676010

Ethacrynic acid L-cysteine adduct

CAS: 51246-37-8

Ethacrynic acid L-cysteine adduct (EAC) is a non-competitive inhibitor of phosphatases. It is a β-unsaturated ketone that has been shown to inhibit the phosphatase activity of pepsin and other enzymes. EAC binds to glutathione, forming an inactive covalent bond. The glutathione conjugate is inactivated by incubation with aminopyrine and pepsin, which degrades the glutathione moiety. This leads to the formation of a phosphatase inhibitor that is catalytic and competitive in nature. EAC can be used as a reagent for cell culture media or tissue sections, where it inhibits the activity of phosphatases that might interfere with certain enzymatic reactions.

Formula: C₁₆H₁₉Cl₂NO₆S

Purity: Min. 95%

Molecular weight: 424.3 g/mol

Ref: 3D-FE22849