CAS 5132-79-6

2-amino-9-(2-deoxypentofuranosyl)-1-methyl-1,9-dihydro-6H-purin-6-one

Description:

2-amino-9-(2-deoxypentofuranosyl)-1-methyl-1,9-dihydro-6H-purin-6-one, commonly known as a nucleoside analog, is characterized by its purine base structure, which is essential in the formation of nucleic acids. This compound features an amino group at the 2-position and a methyl group at the 1-position of the purine ring, contributing to its biological activity. The presence of a 2-deoxypentofuranosyl moiety indicates that it is a sugar component, specifically a deoxyribose, which is crucial for its role in nucleic acid synthesis. This substance is typically involved in biochemical processes, particularly in the context of antiviral and anticancer therapies, as it can mimic natural nucleosides and interfere with nucleic acid metabolism. Its solubility and stability in biological systems can vary, influencing its pharmacokinetic properties. Overall, this compound exemplifies the structural complexity and functional significance of nucleoside derivatives in medicinal chemistry.

Formula: C₁₁H₁₅N₅O₄

InChI: InChI=1/C11H15N5O4/c1-15-10(19)8-9(14-11(15)12)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14)

SMILES: Cn1c(=O)c2c([nH]c1=N)n(cn2)C1CC(C(CO)O1)O

Synonyms:

• 2’-Deoxy-N1-methylguanosine
• Guanosine, 2'-deoxy-1-methyl-
• N1-METHYL-2'-DEOXYGUANOSINE
• 2'-Deoxy-N1-methylguanosine

2'-Deoxy-N1-methylguanosine

CAS: 5132-79-6

2'-Deoxy-N1-methylguanosine is a Nucleoside Derivative - N-Methylated nucleoside.

Formula: C₁₁H₁₅N₅O₄

Color and Shape: Solid

Molecular weight: 281.27

Ref: TM-TNU1267

N1-Methyl-2’-deoxyguanosine

Controlled Product

CAS: 5132-79-6

Applications N1-Methyl-2’-deoxyguanosine is a model for alkylation of DNA. Also, it is formed from the reaction of 2’-Deoxyguanosine with N-Nitroso-N-methyl-N’-phenylurea in methanol.
References Fenselau, C., et al.: Adv. Mass. Spectrom., 7B, 1572-1577 (1978); Yoshida, K., et al.: Nucleic Acids Symp., 31, 111-112 (1994)

Formula: C₁₁H₁₅N₅O₄

Color and Shape: Neat

Molecular weight: 281.27

Ref: TR-M293030

2’-Deoxy-N1-methylguanosine

Controlled Product

CAS: 5132-79-6

2’-Deoxy-N1-methylguanosine is a modified purine nucleoside composed of a N¹-methylguanine, a guanine base where a methyl group is attached to the nitrogen at position 1 (N¹). This methylation blocks normal Watson-Crick base pairing, especially with cytosine, and can affect RNA structure and function. It also contains a 2′-Deoxyribose and has possible research applications

Formula: C₁₁H₁₅N₅O₄

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 281.27 g/mol

Ref: 3D-ND163165