CAS 51372-28-2
:(22S)-Budesonide
Description:
(22S)-Budesonide is a synthetic glucocorticoid steroid that is primarily used for its anti-inflammatory properties in the treatment of various respiratory conditions, such as asthma and chronic obstructive pulmonary disease (COPD). It is characterized by its potent anti-inflammatory effects, which are achieved through the modulation of gene expression and inhibition of pro-inflammatory cytokines. The compound has a high affinity for the glucocorticoid receptor, leading to a reduction in inflammation and immune response. (22S)-Budesonide is typically administered via inhalation or as a nasal spray, allowing for localized effects with minimal systemic absorption, which helps to reduce potential side effects commonly associated with systemic corticosteroids. Its pharmacokinetics include rapid metabolism and a relatively short half-life, necessitating regular dosing for sustained therapeutic effects. The substance is also notable for its low bioavailability when taken orally, further emphasizing its design for targeted delivery in respiratory therapies. Overall, (22S)-Budesonide is an important medication in managing chronic inflammatory conditions of the airways.
Formula:C25H34O6
InChI:InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21-,22+,23-,24-,25+/m0/s1
InChI key:InChIKey=VOVIALXJUBGFJZ-AMTWPJRWSA-N
SMILES:C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@H](CCC)O2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H])[H]
Synonyms:- (11β,16α)-16,17-[(1S)-Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
- (22S)-Budesonide
- (S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
- Budesonide (11beta,16alpha(S))
- Pregna-1,4-diene-3,20-dione, 16,17-[(1S)-butylidenebis(oxy)]-11,21-dihydroxy-, (11β,16α)-
- Pregna-1,4-diene-3,20-dione, 16,17-[butylidenebis(oxy)]-11,21-dihydroxy-, [11β,16α(S)]-
- Unii-168L5Ht37P
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Found 3 products.
(22S)-Budesonide
CAS:Controlled Product<p>Applications Budesonide (B689490) epimer S. Budesonide 22R epimer is more active than 22S epimer. Used as an antiinflammatory agent.<br>References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979), Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980), Clissold, S.P., et al.: Drugs, 28, 485 (1984),<br></p>Formula:C25H34O6Color and Shape:NeatMolecular weight:430.53
