CAS 514-39-6

Periplogenin

Description:

Periplogenin, with the CAS number 514-39-6, is a naturally occurring flavonoid compound primarily found in certain plant species, particularly within the family of Annonaceae. It is characterized by its polyphenolic structure, which contributes to its antioxidant properties. Periplogenin exhibits a yellowish color and is soluble in organic solvents, while its solubility in water is limited. This compound has garnered interest in pharmacological research due to its potential anti-inflammatory, antimicrobial, and anticancer activities. Additionally, it may play a role in protecting cells from oxidative stress. The presence of hydroxyl groups in its structure enhances its reactivity and biological activity. As with many flavonoids, Periplogenin's effects can be influenced by its concentration and the specific biological context in which it is studied. Overall, its unique chemical properties and biological activities make it a subject of interest in both natural product chemistry and medicinal research.

Formula: C₂₃H₃₄O₅

InChI: InChI=1/C23H34O5/c1-20-7-3-15(24)12-22(20,26)9-5-18-17(20)4-8-21(2)16(6-10-23(18,21)27)14-11-19(25)28-13-14/h11,15-18,24,26-27H,3-10,12-13H2,1-2H3/t15-,16+,17-,18+,20+,21+,22-,23-/m0/s1

InChI key: InChIKey=QJPCKAJTLHDNCS-FBAXFMHRSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)[C@](O)(CC3)C[C@@H](O)CC4)(CC[C@]1(C)[C@H](CC2)C5=CC(=O)OC5)[H])[H]

Synonyms:

• (3β,5β)-3,5,14-Trihydroxycard-20(22)-enolide
• 3b,5,14-Trihydroxy-5b-card-20(22)-enolide
• 3β,5β,14β-Trihydroxy-20(22)-cardenolide
• 3β,5β,14β-Trihydroxy-8βH-card-20(22)-enolide
• 5β-Card-20(22)-enolide, 3β,5,14-trihydroxy-
• 5β-Hydroxydigitoxigenin
• Card-20(22)-Enolide, 3,5,14-Trihydroxy-, (3Beta,5Beta)-
• Card-20(22)-enolide, 3,5,14-trihydroxy-, (3.beta.,5.beta.)-
• Card-20(22)-enolide, 3,5,14-trihydroxy-, (3β,5β)-
• Desoxostrophanthidin
• Periplogenin
• (3beta,5beta)-3,5,14-Trihydroxycard-20(22)-enolide
• 3β,5,14-Trihydroxy-5β-cardanolide-20(22)-ene
• 3β,5,14-Trihydroxy-5β,14β-card-20(22)-enolide
• Card-20(22)-enolide, 3,5,14-trihydroxy-, (3-beta,5-beta)- (9ci)
• 5-beta-Hydroxydigitoxigenin
• 5-beta-Card-20(22)-enolide, 3-beta,5,14-trihydroxy-

Periplogenin

CAS: 514-39-6

Formula: C₂₃H₃₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 390.5131

Ref: IN-DA00DGRJ

Periplogenin

CAS: 514-39-6

Formula: C₂₃H₃₄O₅

Molecular weight: 390.52

Ref: 7W-GY2040

Periplogenin

CAS: 514-39-6

Periplogenin

Purity: ≥98%

Molecular weight: 390.51g/mol

Ref: 54-BUP08694

Periplogenin

CAS: 514-39-6

Periplogenin plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and/or LPO inhibiting properties. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models.

Formula: C₂₃H₃₄O₅

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 390.52

Ref: BP-BP1613

Periplogenin

CAS: 514-39-6

1.

Formula: C₂₃H₃₄O₅

Purity: 99.67% - 99.91%

Color and Shape: Solid

Molecular weight: 390.51

Ref: TM-T4S1983

Periplogenin

CAS: 514-39-6

Periplogenin is a compound classified as a cardiac glycoside, which is typically derived from certain plant species such as those in the Apocynaceae family. These compounds are known for affecting the heart by influencing cellular ion transport mechanisms. The primary mode of action of periplogenin involves inhibition of the Na⁺/K⁺-ATPase pump. This inhibition leads to an increased intracellular concentration of sodium ions, which indirectly increases intracellular calcium levels via the sodium-calcium exchanger. The elevated calcium concentration enhances cardiac muscle contractility, a mechanism often leveraged in treating certain heart conditions.

Formula: C₂₃H₃₄O₅

Purity: Min. 95%

Molecular weight: 390.51 g/mol

Ref: 3D-FP167441

Periplogenin

Controlled Product

CAS: 514-39-6

Applications Periplogenin can be regarded as one of the active anti-inflammation components of traditional Chinese medicine Cortex Periplocae. Periplogenin exhibits an anti-cancer effect on S180 sarcoma xeno-grafted mice.
References Han, Y., et al.: Zhongguo Xiaoer Xueye Yu Zhongliu Zazhi, 13, 1 (2008); Gu, W., et al.: Zhongguo Yaofang, 19, 166 (2008); Chen, S., et al.: Zhongcaoyao, 37, 519 (2006)

Formula: C₂₃H₃₄O₅

Color and Shape: Neat

Molecular weight: 390.513

Ref: TR-P291205