CAS 5142-22-3

N1-Methyladenine

Description:

N1-Methyladenine is a modified nucleobase derived from adenine, characterized by the addition of a methyl group at the nitrogen atom in the N1 position. This compound is notable for its role in various biological processes, particularly in the context of nucleic acid metabolism and function. It is often found in certain types of RNA and is involved in the regulation of gene expression. N1-Methyladenine exhibits properties typical of purine bases, including the ability to form hydrogen bonds and participate in base pairing, albeit with altered stability and reactivity compared to unmodified adenine. The compound is soluble in polar solvents and can be synthesized through methylation reactions involving adenine. Its presence in biological systems can influence cellular processes, including signal transduction and the stability of RNA molecules. As a research chemical, N1-Methyladenine is of interest in studies related to epigenetics and the development of therapeutic agents targeting nucleic acid interactions.

Formula: C₆H₇N₅

InChI: InChI=1S/C6H7N5/c1-11-3-10-6-4(5(11)7)8-2-9-6/h2-3H,7H2,1H3

InChI key: InChIKey=HPZMWTNATZPBIH-UHFFFAOYSA-N

SMILES: NC1=C2C(N=CN1C)=NC=N2

Synonyms:

• 1-Methyl-1H-purin-6-amine
• 1-Methyl-6-aminopurine
• 1-Methylpurin-6-amine
• 1-methyl-1,7-dihydro-6H-purin-6-imine
• 1H-Purin-6-amine, 1-methyl-
• 1H-Purin-6-amine, 1-methyl- (9CI)
• 6-Amino-1-methylpurine
• 6H-Purin-6-imine, 1,9-dihydro-1-methyl-
• Adenine, 1-methyl-
• N¹-Methyladenine
• Nsc 70896
• N1-Methyladenine

1H-​Purin-​6-​amine, 1-​methyl-

CAS: 5142-22-3

Formula: C₆H₇N₅

Purity: 98.49%

Color and Shape: Solid

Molecular weight: 149.1533

Ref: IN-DA00DDR0

1-Methyladenine

CAS: 5142-22-3

1-Methyladenine

Purity: ≥95%

Molecular weight: 149.15g/mol

Ref: 54-OR1007290

1H-Purin-6-amine, 1-methyl-

CAS: 5142-22-3

Purity: 98%

Molecular weight: 149.1569977

Ref: 10-F866561

1-Methyladenine-13C,d3

Controlled Product

CAS: 5142-22-3

Formula: CC₅D₃H₄N₅

Color and Shape: Neat

Molecular weight: 153.164

Ref: TR-M143937

1-Methyladenine-13C

Controlled Product

CAS: 5142-22-3

Formula: CC₅H₇N₅

Color and Shape: Neat

Molecular weight: 150.146

Ref: TR-M143936

1-Methyladenine

CAS: 5142-22-3

1-Methyladenine is a nucleotide analog that inhibits the binding of adenine and guanine to the α-subunit of GTP. It inhibits the synthesis of DNA, RNA, and protein by blocking the assembly of ribosomes. 1-Methyladenine is used in cancer therapy as an adjunct to temozolomide chemotherapy. The drug has been shown to increase the sensitivity of detection for tumor cells by inhibiting DNA synthesis, which leads to cell death. 1-Methyladenine also has a physiological effect on female reproduction, causing inhibition of meiosis and ovulation in oocytes. It does not have these effects on male reproduction or on body formation.

Formula: C₆H₇N₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 149.15 g/mol

Ref: 3D-FM138833

1-Methyladenine

CAS: 5142-22-3

1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes.

Formula: C₆H₇N₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 149.15

Ref: TM-T10018