CAS 51481-60-8
:Naloxone hydrochloride dihydrate
Description:
Naloxone hydrochloride dihydrate is a potent opioid antagonist primarily used in the emergency treatment of opioid overdose. It is a white to off-white crystalline powder that is soluble in water, which facilitates its administration via intravenous, intramuscular, or subcutaneous routes. The chemical formula for naloxone hydrochloride dihydrate is C17H19NO4·HCl·2H2O, indicating the presence of two water molecules in its hydrated form. This compound works by competitively binding to opioid receptors in the central nervous system, effectively reversing the effects of opioid agonists. Naloxone has a rapid onset of action, typically within minutes, and its effects can last from 30 to 90 minutes, necessitating careful monitoring due to the potential for re-narcotization. It is generally well-tolerated, with few side effects, although withdrawal symptoms may occur in opioid-dependent individuals. Naloxone's accessibility and effectiveness have made it a critical tool in combating the opioid crisis, often distributed in community programs to increase its availability in emergency situations.
Formula:C19H26ClNO6
InChI:InChI=1/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
InChI key:InChIKey=TXMZWEASFRBVKY-IOQDSZRYSA-N
SMILES:O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC=C)CC4)[H].Cl.O
Synonyms:- Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, dihydrate, (5α)-
- Naloxone HCl dihydrate
- Nyxoid
- naloxone F&D version of N7758
- Naloxone hydrochloride dihydrate
- Naloxone dihydrate hydrochloride
- 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride dihydrate
- NaloxonHCl-Dihydrat
- NALOXONE F&D VERSION OF N7758 FOR HUMA&
- NALOXONE F&D VERSION OF N7758 FOR &
- NaloxonhydrochloridDihydrat
- Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, dihydrate, (5.alpha.)-
- See more synonyms
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Found 12 products.
Naloxone Hydrochloride Dihydrate 1.0 mg/ml in Methanol (as anhydrous free base)
CAS:Color and Shape:Single SolutionNALOXONE HYDROCHLORIDE RS
CAS:NALOXONE HYDROCHLORIDE RSFormula:C19H26ClNO6Color and Shape:PowderMolecular weight:399.8658NALOXONE FOR PEAK IDENTIFICATION CRS
CAS:NALOXONE FOR PEAK IDENTIFICATION CRSFormula:C19H26ClNO6Color and Shape:PowderMolecular weight:399.8658Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-,hydrochloride, dihydrate, (5a)-
CAS:Formula:C19H26ClNO6Purity:98%Color and Shape:SolidMolecular weight:399.8658Naloxone hydrochloride dihydrate
CAS:Formula:C19H21NO4·HCl·2H2OPurity:98.0 - 102.0 % (dried basis)Color and Shape:White to off-white powderMolecular weight:399.87Naloxone Hydrochloride Dihydrate
CAS:Controlled ProductFormula:C19H21NO4·ClHH2OColor and Shape:NeatMolecular weight:399.87Naloxone Hydrochloride Dihydrate
CAS:Formula:C19H21NO4·ClH·2H2OColor and Shape:White To Off-WhiteMolecular weight:399.87Naloxone hydrochloride dihydrate
CAS:Controlled ProductNaloxone hydrochloride dihydrate is a drug that blocks the effects of opioids. It is administered by injection and has a short half-life. Naloxone hydrochloride dihydrate binds to opioid receptors in the central nervous system, which prevents binding by other opioids. This results in an increased metabolic rate, which can be used as a marker for effectiveness of treatment. Naloxone hydrochloride dihydrate has been shown to have an inhibitory effect on monoamine neurotransmitters, including dopamine, serotonin and norepinephrine. The use of this drug should be limited to outpatients because it produces less physical dependence than other opioids. Naloxone hydrochloride dihydrate can also be used as a sample preparation agent for urine samples or as an effective dose for pharmaceutical preparations.END>Formula:C19H26NO6ClPurity:98 To 100%Color and Shape:White Off-White PowderMolecular weight:399.87 g/mol
