CAS 51568-18-4

Succinylacetone

Description:

Succinylacetone is an organic compound characterized by its structure, which includes a five-carbon chain with two carbonyl groups. It is a colorless to pale yellow solid that is soluble in organic solvents but has limited solubility in water. Succinylacetone is known for its role as a biomarker in certain metabolic disorders, particularly in the diagnosis of tyrosinemia type I, where it accumulates due to the deficiency of specific enzymes involved in the breakdown of tyrosine. The compound exhibits both ketone and carboxylic acid functional groups, contributing to its reactivity and potential interactions with biological systems. Additionally, succinylacetone can chelate metal ions, which may influence its biological activity and toxicity. Its synthesis typically involves the condensation of acetic acid derivatives and succinic acid, and it can be analyzed using techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Overall, succinylacetone serves as an important compound in both clinical diagnostics and biochemical research.

Formula: C₇H₁₀O₄

InChI: InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)

InChI key: InChIKey=WYEPBHZLDUPIOD-UHFFFAOYSA-N

SMILES: C(CCC(O)=O)(CC(C)=O)=O

Synonyms:

• Ccris 1387
• Heptanoic acid, 4,6-dioxo-
• Nsc 174804
• Succinyl acetone
• Succinylacetone
• 4,6-Dioxoheptanoic acid

4,6-Dioxoheptanoic acid

CAS: 51568-18-4

Formula: C₇H₁₀O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 158.1519

Ref: IN-DA003KJV

4,6-Dioxoheptanoic Acid

CAS: 51568-18-4

4,6-Dioxoheptanoic Acid

Purity: 99%

Molecular weight: 158.15g/mol

Ref: 54-OR1025565

4,6-Dioxoheptanoic acid

CAS: 51568-18-4

Formula: CH₃COCH₂COCH₂CH₂CO₂H

Molecular weight: 158.15

Ref: 7W-GL0740

4,6-Dioxoheptanoic acid

CAS: 51568-18-4

4,6-Dioxoheptanoic acid

Purity: ≥95%

Molecular weight: 158.15g/mol

Ref: 54-BUP14467

4,6-Dioxoheptanoic acid

CAS: 51568-18-4

4,6-Dioxoheptanoic acid (Succinylacetone) acts as a potent inhibitor of heme biosynthesis.

Formula: C₇H₁₀O₄

Purity: 97.18% - ≥98%

Color and Shape: Powder

Molecular weight: 158.15

Ref: TM-T8273

Succinylacetone

CAS: 51568-18-4

Applications Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotope for the determination of SA in dried blood spots (DBS) and liquid urine using a 13C4-SA as internal standard. The method was applied retrospectively and prospectively for the diagnosis of hepatorenal tyrosinemia and for follow-up of patients under treatment.
References Kvittingen, E., et al.: Inher. Metab. Dis., 14, 554 (1991), Lindstedt, S., et al.: Lancet, 340, 813 (1992), Schulze, A., et al.: Clin. Chem., 47, 1424 (2001), Allard, P., et al.: Clin. Biochem., 37, 1010 (2004),

Formula: C₇H₁₀O₄

Color and Shape: White To Off-White

Molecular weight: 158.15

Ref: TR-S692060

Succinylacetone-13C7

CAS: 51568-18-4

Applications Succinylacetone-13C7 is a labelled analogue of Succinylacetone (S692060). Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotope for the determination of SA in dried blood spots (DBS) and liquid urine using a 13C4-SA as internal standard. The method was applied retrospectively and prospectively for the diagnosis of hepatorenal tyrosinemia and for follow-up of patients under treatment.
References Kvittingen, E., et al.: Inher. Metab. Dis., 14, 554 (1991), Lindstedt, S., et al.: Lancet, 340, 813 (1992), Schulze, A., et al.: Clin. Chem., 47, 1424 (2001), Allard, P., et al.: Clin. Biochem., 37, 1010 (2004),

Formula: C₇H₁₀O₄

Color and Shape: Neat

Molecular weight: 158.15

Ref: TR-S692063

4,6-Dioxoheptanoic acid

CAS: 51568-18-4

Formula: C₇H₁₀O₄

Purity: 95%

Molecular weight: 158.153

Ref: 10-F226493