CAS 515814-01-4

6-[(3R)-Hydroxy-(4R)-methyl-2(S)-(methylamino)-6(E),8-nonadienoic acid]ciclosporin A

Description:

6-[(3R)-Hydroxy-(4R)-methyl-2(S)-(methylamino)-6(E),8-nonadienoic acid]ciclosporin A, identified by CAS number 515814-01-4, is a derivative of ciclosporin A, a well-known immunosuppressant. This compound features a complex cyclic structure with multiple chiral centers, contributing to its unique pharmacological properties. The presence of a hydroxy group and a methylamino group enhances its solubility and bioactivity, potentially improving its therapeutic efficacy. The nonadienoic acid moiety suggests that it may interact with biological membranes or proteins, influencing its mechanism of action. As with other ciclosporin derivatives, it is likely to exhibit immunosuppressive effects by inhibiting T-cell activation and proliferation, making it relevant in transplant medicine and autoimmune disorders. The specific stereochemistry of this compound is crucial for its biological activity, as even slight changes in configuration can significantly alter its interaction with target molecules. Overall, this compound represents a specialized area of research in medicinal chemistry, focusing on optimizing immunosuppressive therapies.

Formula: C₆₃H₁₁₁N₁₁O₁₂

Synonyms:

• Voclosporin
• Isa-247
• ISAtx-247
• R-1524

Voclosporin

CAS: 515814-01-4

Voclosporin

Purity: ≥98%

Molecular weight: 1214.62g/mol

Ref: 54-BUP05229

Voclosporin

CAS: 515814-01-4

Formula: C₆₃H₁₁₁N₁₁O₁₂

Molecular weight: 1214.65

Ref: 4Z-PV-095001

Voclosporin

CAS: 515814-01-4

Voclosporin (ISAtx-247) is a novel and orally available calcium-modulated phosphatase (CN; PP2B) inhibitor and immunosuppressant for the treatment of lupus

Formula: C₆₃H₁₁₁N₁₁O₁₂

Purity: 99.85%

Color and Shape: Solid

Molecular weight: 1214.62

Ref: TM-T17235

Voclosporin-d4

Controlled Product

CAS: 515814-01-4

Applications Labelled Voclosporin (V678500). A new agent for the treatment of noninfectious uveitis. Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. Voclosporin, a rationally designed novel calcineurin inhibitor, exhibits a favorable safety profile, a strong correlation between pharmacokinetic and pharmacodynamic response, and a wide therapeutic window. Immunosuppressant.
References Aspeslet, L., et al.: Transplant Proc., 33, 1048 (2001), Cho, M., et al.: Arthritis Rheum., 46, 1202 (2002), Staatz, C., et al.: Clin. Pharmacokinet., 43, 623 (2004),

Formula: C₆₃H₁₀₇D₄N₁₁O₁₂

Color and Shape: Neat

Molecular weight: 1218.65

Ref: TR-V678502

Voclosporin

CAS: 515814-01-4

Voclosporin is a drug that belongs to the class of immunosuppressants and is used to treat autoimmune diseases. Voclosporin inhibits P-glycoprotein (P-gp) and blocks the transport of some drugs from the gut into the bloodstream. The effect of voclosporin on P-gp has been shown using in vitro studies, x-ray crystal structures, and in vivo animal models. Voclosporin also inhibits inflammatory substances such as prostaglandins and leukotrienes, which are produced by immune cells and contribute to inflammation. This drug has also been shown to be effective against eye disorders such as uveitis, retinal detachment, and macular edema. Voclosporin is metabolized through a number of metabolic reactions including CYP3A4/5 enzyme oxidation or glucuronidation followed by a number of other reactions including cleavage by carboxylesterase or esterases to form 5′-desacet

Formula: C₆₃H₁₁₁N₁₁O₁₂

Purity: 90%Min

Color and Shape: Powder

Molecular weight: 1,214.62 g/mol

Ref: 3D-FV28719