CAS 51596-10-2

(6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B

Description:

(6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B, with CAS number 51596-10-2, is a member of the milbemycin class of compounds, which are known for their insecticidal and acaricidal properties. This substance features a complex molecular structure characterized by multiple rings and functional groups, including an epoxy group and a methyl group, which contribute to its biological activity. The stereochemistry indicated by the (6R,25R) configuration suggests specific spatial arrangements of atoms that can influence the compound's interaction with biological targets. Milbemycins are typically derived from natural sources, particularly from the fermentation of certain Streptomyces species. They function by disrupting the nervous system of pests, leading to paralysis and death. This compound is of interest in agricultural and veterinary applications due to its effectiveness against a range of pests while exhibiting low toxicity to mammals. As with many specialized chemical substances, handling and usage should adhere to safety guidelines to mitigate any potential risks.

Formula: C₃₁H₄₄O₇

InChI: InChI=1/C31H44O7/c1-18-7-6-8-23-17-35-28-27(32)21(4)14-26(31(23,28)34)29(33)36-25-15-24(10-9-19(2)13-18)38-30(16-25)12-11-20(3)22(5)37-30/h6-9,14,18,20,22,24-28,32,34H,10-13,15-17H2,1-5H3/b7-6+,19-9+,23-8-/t18-,20-,22?,24?,25-,26-,27+,28+,30-,31+/m0/s1

InChI key: InChIKey=ZLBGSRMUSVULIE-GSMJGMFJSA-N

SMILES: C[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/C[C@@H](C)/C=C/C=C\4/[C@@]5(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]5(OC4)[H])[H])[H])[H])CC[C@@H]1C

Synonyms:

• Spiro[11,15-methano-2H,7H,13H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], milbemycin B deriv.
• Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-25-methyl-, (6R,25R)-
• Antibiotic B 41A3
• (6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B
• Milbemycin α1
• milbemycin
• (25R)-25-Methyl-5β-hydroxy-5-demethoxy-28-O,6β-cyclomilbemycin B
• Milbemite Impurity 1
• Milbemycin EP Imp B
• Milbemycin Impurity 2(Milbemycin EP Impurity B)
• Milbemycin oxime A3
• (+)-Chloropseudoephedrine (hydrochloride)
• milbemycin A3
• milbemycinb-2
• milbemectine a3
• Milbemycin EP Impurity B
• Milbemycin Oxime EP Impurity B
• B 41A3, MilbeMycin alpha1, MilbeMectin

Milbemycin A3

CAS: 51596-10-2

Milbemycin A3, from S. hygroscopicus fermentation, opens glutamate/GABA channels. Used as a nematocide/insecticide; effective against mites and C. elegans.

Formula: C₃₁H₄₄O₇

Color and Shape: Solid

Molecular weight: 528.686

Ref: TM-T35746

Milbemycin A3

CAS: 51596-10-2

Milbemycin A3

Purity: 98%

Ref: 54-OR1039800

Milbemectin A3 10 µg/mL in Acetonitrile

CAS: 51596-10-2

Formula: C₃₁H₄₄O₇

Color and Shape: Colourless

Molecular weight: 528.68

Ref: 04-L15265020AL

Milbemectin A3

CAS: 51596-10-2

Formula: C₃₁H₄₄O₇

Molecular weight: 528.69

Ref: 4Z-M-195001

Milbemycin A3

CAS: 51596-10-2

Formula: C₃₁H₄₄O₇

Ref: TR-M344295

Milbemycin EP Impurity B

CAS: 51596-10-2

Formula: C₃₁H₄₄O₇

Molecular weight: 528.69

Ref: ST-EA-CP-M95002

Milbemectin A3

CAS: 51596-10-2

Milbemectin A3 is a macrolide antibiotic that belongs to the group of milbemycins. It is a prodrug that is hydrolyzed in vivo to moxidectin, its active form. Milbemectin A3 has been shown to be effective against wild-type strains of c. glabrata and anthelmintic drug-resistant strains of c. elegans, as well as some other parasites such as Toxocara canis and Toxascaris leonina. Milbemectin A3 has also been shown to cause liver lesions at high doses in rats, although it does not have any toxic effects on the heart or lungs. Milbemectin A3 binds to drug transporter proteins, which leads to an increase in the concentration of this drug at the site of infection, making it more effective at killing parasites.

Formula: C₃₁H₄₄O₇

Purity: Min. 95 Area-%

Color and Shape: White To Off-White Solid

Molecular weight: 528.68 g/mol

Ref: 3D-FM157340