CAS 516-12-1

N-Iodosuccinimide

Description:

N-Iodosuccinimide (NIS) is an organic compound with the molecular formula C4H4N2O2I. It is a white to pale yellow crystalline solid that is primarily used as a reagent in organic synthesis, particularly for the iodination of various substrates. NIS is known for its mild and selective oxidizing properties, making it valuable in the preparation of iodinated compounds. The compound is soluble in polar solvents such as water and methanol, but less soluble in non-polar solvents. N-Iodosuccinimide is often utilized in reactions involving alkenes, alcohols, and aromatic compounds, facilitating the introduction of iodine into organic molecules. Additionally, it can serve as a source of iodine in radical reactions and is employed in the synthesis of pharmaceuticals and agrochemicals. Due to its reactivity, NIS should be handled with care, as it can be hazardous if ingested or inhaled, and appropriate safety measures should be taken during its use in laboratory settings.

Formula: C₄H₄INO₂

InChI: InChI=1/C4H4INO2/c5-6-3(7)1-2-4(6)8/h1-2H2

InChI key: InChIKey=LQZMLBORDGWNPD-UHFFFAOYSA-N

SMILES: IN1C(=O)CCC1=O

Synonyms:

• 1-Iodo-2,5-Pyrrolidinedione
• 1-Iodo-5-Pyrrolidinedione
• 1-Iodopyrrolidine-2,5-Dione
• 2,5-Pyrrolidinedione, 1-iodo-
• Iodosuccinimide
• N-Iodo-Succinimid
• NIS
• Succinimide,N-iodo-
• Succiniodimide
• N-Iodosuccinimide
• N-Iodosuccinimide , (1-Iodo-2,5-pyrrolidinedione)
• N-Iodosuccinimide, 98+%
• N-Iodosuccinimide ,99%

N-Iodosuccinimide

CAS: 516-12-1

Formula: C₄H₄INO₂

Purity: >99.0%(T)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 224.99

Ref: 3B-I0074

N-Iodosuccinimide, 97%

CAS: 516-12-1

N-Iodosuccinimide is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively.

Formula: C₄H₄INO₂

Purity: 97%

Color and Shape: Crystals or powder or crystalline powder., White to yellow to brown

Molecular weight: 224.99

Ref: 02-A14320

N-Iodosuccinimide

CAS: 516-12-1

Formula: C₄H₄INO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 224.9845

Ref: IN-DA0035TM

N-Iodosuccinimide

CAS: 516-12-1

N-Iodosuccinimide

Formula: C₄H₄INO₂

Purity: 98%

Color and Shape: faint brown powder

Molecular weight: 224.98453g/mol

Ref: 54-OR28900

N-Iodosuccinimide

CAS: 516-12-1

Formula: C₄H₄INO₂

Purity: 98.0%

Color and Shape: Crystalline Powder

Molecular weight: 224.985

Ref: 10-F003418

N-Iodosuccinimide

CAS: 516-12-1

Formula: C₄H₄INO₂

Purity: 98.0 - 102.0 %

Color and Shape: White to pale yellow crystalline powder

Molecular weight: 224.99

Ref: 7W-GK8008

N-Iodosuccinimide

CAS: 516-12-1

N-Iodosuccinimide is a reagent that is used in the synthesis of monoclonal antibodies. It reacts with the amino groups of proteins to form stable complexes that are soluble in organic solvents. N-Iodosuccinimide can also be used for the treatment of tumors by reacting with DNA to form cross-links and inhibiting tumor cell growth. N-Iodosuccinimide reacts with methyl ketones to form mixtures of stable complexes, which are useful for the synthesis of polymers and polyesters. This reaction mechanism is a variation on the Suzuki coupling reaction and has been shown to be effective for cervical cancer cells in culture.

Formula: C₄H₄INO₂

Color and Shape: Brown Clear Liquid

Molecular weight: 224.98 g/mol

Ref: 3D-FI07623

N-Iodosuccinimide extrapure, 99%

CAS: 516-12-1

Formula: C₄H₄INO₂

Purity: min. 99.0%

Color and Shape: Off-white to yellow to tan, Crystalline powder

Molecular weight: 224.98

Ref: SR-70031

N-Iodosuccinimide

Controlled Product

CAS: 516-12-1

Applications N-Iodosuccinimide is a iodo substituted succinimide that is used as an iodinating agent in chemical synthesis.
References Castanet, A.-S. et al.: Tetrahed. Lett., 43, 5047 (2002);

Formula: C₄H₄INO₂

Color and Shape: Neat

Molecular weight: 224.99

Ref: TR-I719900