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CAS 516-21-2

:

Cycloguanil

Description:
Cycloguanil, with the CAS number 516-21-2, is a synthetic compound that belongs to the class of antimalarial drugs. It is a derivative of guanidine and is primarily known for its role as an active metabolite of proguanil, which is used in the treatment and prevention of malaria. Cycloguanil exhibits a mechanism of action that involves the inhibition of dihydrofolate reductase, an enzyme critical for the synthesis of folate in the malaria parasite, thereby disrupting its growth and replication. The compound is characterized by its relatively low solubility in water, which can affect its bioavailability. Cycloguanil is typically administered in conjunction with other antimalarial agents to enhance therapeutic efficacy. Its pharmacokinetic properties include a moderate half-life, allowing for effective dosing regimens. While it is generally well-tolerated, potential side effects may include gastrointestinal disturbances and hypersensitivity reactions. Overall, cycloguanil plays a significant role in malaria treatment protocols, particularly in combination therapies.
Formula:C11H14ClN5
InChI:InChI=1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16)
InChI key:InChIKey=QMNFFXRFOJIOKZ-UHFFFAOYSA-N
SMILES:CC1(C)N(C(N)=NC(N)=N1)C2=CC=C(Cl)C=C2
Synonyms:
  • 1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-
  • 1-(4-Chlorophenyl)-1,6-Dihydro-6,6-Dimethyl-1,3,5-Triazine-2,4-Diyldiamine
  • 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine
  • 1-(4-Chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-1,3,5-triazine
  • 1-(4-Chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
  • 1-(p-Chlorophenyl)-1,2-dihydro-2,2-dimethyl-4,6-diamino-s-triazine
  • 4,6-Diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine
  • Chlorazin
  • Chlorazine
  • Chlorguanide triazine
  • See more synonyms
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