CAS 516-41-6

5α-Dihydrocortisol

Description:

5α-Dihydrocortisol, with the CAS number 516-41-6, is a steroid hormone that is a derivative of cortisol, specifically characterized by the reduction of the double bond in the A-ring of the steroid structure. It is a biologically active compound that plays a role in various physiological processes, including the regulation of metabolism, immune response, and stress response. This compound is known for its anti-inflammatory properties and is involved in the metabolism of carbohydrates, proteins, and fats. In terms of its chemical structure, 5α-Dihydrocortisol features a hydroxyl group at the C11 position, which is crucial for its biological activity. The substance is typically found in the adrenal cortex and can be synthesized from cortisol through enzymatic reduction. Its pharmacological effects are similar to those of cortisol, but it may exhibit different potency and efficacy in various biological contexts. Due to its hormonal nature, 5α-Dihydrocortisol is of interest in both clinical and research settings, particularly in studies related to adrenal function and disorders.

Formula: C₂₁H₃₂O₅

InChI: InChI=1S/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12,14-16,18,22,24,26H,3-11H2,1-2H3/t12-,14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key: InChIKey=ACSFOIGNUQUIGE-SERXDUEGSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(CC(=O)CC4)[H])([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (5α,11β)-11,17,21-Trihydroxypregnane-3,20-dione
• (8Xi,9Xi,10Xi,13Xi,14Xi)-11,17,21-Trihydroxypregnane-3,20-Dione
• 11,17,21-Trihydroxypregnane-3,20-dione
• 11beta,17,21-Trihydroxy-5alpha-pregnane-3,20-dione
• 11beta,17alpha,21-Trihydroxy-5alpha-pregnane-3,20-dione
• 11β,17,21-Trihydroxy-5α-pregnane-3,20-dione
• 11β,17α,21-Trihydroxy-5α-pregnane-3,20-dione
• 5-Dihydrocortisol
• 5alpha-Dhf
• 5alpha-Dihydrocortisol
• 5alpha-Pregnane-3,20-dione, 11beta,17,21-trihydroxy-
• 5α-Dihydrocortisol
• 5α-Pregnan-11β,17α,21-triol-3,20-dione
• 5α-Pregnane-3,20-dione, 11β,17,21-trihydroxy-
• Allodihydrocortisol
• Allodihydrohydrocortisone
• Allopregnane-11beta,17alpha,21-triol-3,20-dione
• Allopregnane-11β,17α,21-triol-3,20-dione
• Hydrallostane
• Pregnane-3,20-dione, 11,17,21-trihydroxy-, (5alpha,11beta)-

5a-Dihydrocortisol

Controlled Product

CAS: 516-41-6

Applications Metabolite of Cortisol.
References Clark, D. et al.: Steroids 7, 352 (2006)

Formula: C₂₁H₃₂O₅

Color and Shape: Neat

Molecular weight: 364.48

Ref: TR-D448860

5a-Dihydrocortisol

Controlled Product

CAS: 516-41-6

5a-Dihydrocortisol is an endogenous hormone that has been shown to have a wide variety of effects in the body, including the regulation of blood pressure and collagen synthesis. It also has been shown to enhance protein synthesis in human liver cells and promote the breakdown of fatty acids. 5a-Dihydrocortisol binds to a specific receptor in the cell membrane, which can activate or inhibit intracellular signalling pathways. This drug has been shown to be active against nonsteroidal anti-inflammatory drugs, such as indomethacin, which are often used for osteoarthritis.

Formula: C₂₁H₃₂O₅

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 364.48 g/mol

Ref: 3D-FD22034