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CAS 516-42-7

:

Cortolone

Description:
Cortolone, with the CAS number 516-42-7, is a synthetic corticosteroid that exhibits anti-inflammatory and immunosuppressive properties. It is derived from cortisone and is primarily used in the treatment of various inflammatory conditions, such as arthritis and skin disorders. Cortolone functions by modulating the immune response and inhibiting the release of inflammatory mediators. The substance is characterized by its steroidal structure, which includes a four-ring core typical of steroid hormones, contributing to its biological activity. Cortolone is typically administered in various forms, including topical applications and systemic formulations, depending on the condition being treated. Its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through urine. While effective, cortolone may have side effects, including potential impacts on glucose metabolism, electrolyte balance, and increased susceptibility to infections, necessitating careful monitoring during therapy. As with all corticosteroids, its use should be guided by a healthcare professional to balance therapeutic benefits against possible adverse effects.
Formula:C21H34O5
InChI:InChI=1/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12?,13-,14+,15+,17-,18-,19+,20+,21+/m1/s1
InChI key:InChIKey=JXCOSKURGJMQSG-AZQJGLEESA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C(=O)C1)[H])[H])(CC[C@@]2([C@H](CO)O)O)[H]
Synonyms:
  • (3alpha,5beta,20S)-3,17,20,21-tetrahydroxypregnan-11-one
  • (3α,5β,20S)-3,17,20,21-Tetrahydroxypregnan-11-one
  • 20alpha-Cortolone
  • 20α-Cortolone
  • 3alpha,17alpha,20alpha,21-Tetrahydroxy-5beta-pregnan-11-one
  • 3α,17,20α,21-Tetrahydroxy-5β-pregnan-11-one
  • 3α,17α,20α,21-Tetrahydroxy-5β-pregnan-11-one
  • 5beta-Pregnan-11-one, 3alpha,17,20alpha,21-tetrahydroxy- (8CI)
  • 5beta-Pregnane-3alpha,17,20alpha,21-tetrol-11-one
  • 5β-Pregnan-11-one, 3α,17,20α,21-tetrahydroxy-
  • See more synonyms
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Found 3 products.
  • α-Cortolone
    TRC
    + Info

    α-Cortolone

    Controlled Product
    CAS:
    <p>Applications α-Cortolone is a human urinary metabolite of Cortisol ((H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.<br>References Yergey, A.L., et. al.: Steroids, 60, 295 (1995); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)<br></p>
    Formula:C21H34O5
    Color and Shape:Neat
    Molecular weight:366.49

    Ref: TR-C696280

    25mg
    1,851.00€
    2500µg
    287.00€
  • α-Cortolone
    Targetmol
    + Info

    α-Cortolone

    CAS:
    <p>α-Cortolone, a metabolite of the glucocorticoid cortisol (hydrocortisone), is produced through the action of 20α-hydroxysteroid dehydrogenase (20α-HSD) via a tetrahydrocortisone (THE) intermediate. Studies indicate that urinary levels of α-cortolone are reduced in patients experiencing severe anorexia nervosa and postmenopausal women diagnosed with endometrial adenocarcinoma, in comparison to postmenopausal women without the condition.</p>
    Formula:C21H34O5
    Color and Shape:Solid
    Molecular weight:366.49

    Ref: TM-T84945

  • α-cortolone
    Biosynth
    + Info

    α-cortolone

    CAS:
    <p>Alpha-cortolone is a corticosteroid metabolite, which is a biochemically derived product from the metabolism of cortisol. It is produced in the body through the enzymatic reduction of cortisol, a hormone significantly involved in the stress response, metabolism, and immune function. The mode of action for alpha-cortolone primarily involves its role as a metabolite in the complex steroid hormone pathway. It can influence the regulation of various physiological functions due to its origin from cortisol.</p>
    Formula:C21H34O5
    Purity:Min. 95%
    Molecular weight:366.5 g/mol

    Ref: 3D-AAA51642

    1mg
    303.00€
    5mg
    355.00€
    10mg
    505.00€
    25mg
    898.00€
    50mg
    1,354.00€