CAS 516-90-5

2-{[(3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid

Description:

2-{[(3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid, commonly known as tauroursodeoxycholic acid (TUDCA), is a bile acid derivative with notable biochemical properties. It is characterized by its amphipathic nature, which allows it to interact with both hydrophilic and hydrophobic environments. TUDCA is primarily recognized for its role in promoting cellular health and protecting against apoptosis, particularly in liver cells. It has been studied for its potential therapeutic effects in various liver diseases and neurodegenerative disorders due to its ability to enhance mitochondrial function and reduce endoplasmic reticulum stress. The compound features a steroid backbone, which is typical of bile acids, and contains a sulfonic acid group that contributes to its solubility in water. TUDCA is often used in research settings to investigate its effects on cellular signaling pathways and its potential as a therapeutic agent. Its safety profile and efficacy in clinical applications continue to be explored, making it a compound of interest in both pharmacology and biochemistry.

Formula: C₂₆H₄₅NO₅S

InChI: InChI=1/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1

InChI key: InChIKey=QBYUNVOYXHFVKC-GBURMNQMSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]

Synonyms:

• 2-[[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]amino]-Ethanesulfonic acid
• 3α-Hydroxy-5β-cholanoyltaurine
• 3α-Hydroxy-N-(2-sulfoethyl)-5β-cholan-24-amide
• 516-90-5
• Cholane, ethanesulfonic acid deriv.
• Ethanesulfonic Acid, 2-[[(3A,5B)-3-Hydroxy-24-Oxocholan-24-Yl]Amino]-
• Ethanesulfonic acid, 2-(((3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl)amino)-
• Lithocholic acid taurine conjugate
• Lithocholic acid taurine conjugic acid
• Lithocholyltaurine
• Taurine, N-(3α-hydroxy-5β-cholan-24-oyl)-
• Taurolithocholic acid
• Taurolithocholic Acid D8
• Taurolithocholic Acid MaxSpec? Standard
• 2-[(3α-Hydroxy-24-oxo-5β-cholan-24-yl)amino]ethanesulfonic acid
• Taurolithocholic acidQ: What is
• 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
• Taurolithocholic acid Q: What is the CAS Number of
• N-(3α-Hydroxy-24-oxo-5β-cholan-24-yl)taurine

Taurolithocholic acid

CAS: 516-90-5

Taurolithocholic acid

Purity: 98%

Ref: 54-OR1037184

Taurolithocholic Acid

CAS: 516-90-5

Formula: C₂₆H₄₅NO₅S

Color and Shape: White To Off-White Solid

Molecular weight: 483.71

Ref: 4Z-C-5741

Taurolithocholic-d4 Acid

CAS: 516-90-5

Formula: C₂₆H₄₁NO₅SD₄

Color and Shape: White To Off-White Solid

Molecular weight: 487.74

Ref: 4Z-T-292

Taurolithocholic acid

CAS: 516-90-5

Taurolithocholic acid 3-sulfate (TLC-S) triggers Ca²⁺ signaling in murine pancreatic acinar cells at low micromolar levels, useful in gut metabolism studies.

Formula: C₂₆H₄₅NO₅S

Color and Shape: Solid

Molecular weight: 483.7

Ref: TM-T34788

Taurolithocholic acid

CAS: 516-90-5

Taurolithocholic acid is an analog of bile acid that has shown to have anticancer properties. It induces apoptosis in human tumor cells by inhibiting protein kinases, which are enzymes involved in cell signaling and regulation. Taurolithocholic acid has been found to inhibit the growth of cancer cells in vitro and in vivo, making it a potential candidate for cancer treatment. This compound has also been studied for its ability to inhibit cellulose synthesis and reduce urinary excretion of protein, suggesting possible therapeutic applications beyond cancer treatment. Overall, Taurolithocholic acid shows promising potential as a natural inhibitor of cancer cell growth and proliferation.

Formula: C₂₆H₄₅NO₅S

Purity: Min. 95%

Molecular weight: 483.7 g/mol

Ref: 3D-AAA51690