CAS 5168-36-5

1-(2-deoxypentofuranosyl)-5-hydroxypyrimidine-2,4(1H,3H)-dione

Description:

1-(2-Deoxypentofuranosyl)-5-hydroxypyrimidine-2,4(1H,3H)-dione, with CAS number 5168-36-5, is a nucleoside analog that features a pyrimidine base linked to a deoxypentofuranosyl sugar. This compound is characterized by its structural components, which include a hydroxyl group at the 5-position of the pyrimidine ring and a dione functional group that contributes to its reactivity and potential biological activity. The presence of the deoxypentofuranosyl moiety suggests that it may play a role in nucleic acid metabolism or serve as a building block for nucleic acid synthesis. Its unique structure may impart specific interactions with enzymes or receptors, making it of interest in medicinal chemistry and biochemistry. The compound's solubility, stability, and reactivity can vary based on environmental conditions, such as pH and temperature, which are crucial for its applications in research and potential therapeutic uses. Overall, this substance represents a significant area of study in the context of nucleoside analogs and their biological implications.

Formula: C₉H₁₂N₂O₆

InChI: InChI=1/C9H12N2O6/c12-3-6-4(13)1-7(17-6)11-2-5(14)8(15)10-9(11)16/h2,4,6-7,12-14H,1,3H2,(H,10,15,16)

SMILES: C1C(C(CO)OC1n1cc(c(nc1=O)O)O)O

Synonyms:

• 5-Hydroxy-1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

5-OHdU

CAS: 5168-36-5

5-OHdU

Purity: ≥98%

Molecular weight: 244.2g/mol

Ref: 54-BUP02587

2''-Deoxy-5-hydroxyuridine

CAS: 5168-36-5

Formula: C₉H₁₂N₂O₆

Purity: ≥ 95.0%

Color and Shape: White or almost white crystalline powder

Molecular weight: 244.20

Ref: 7W-GN1740

2’-Deoxy-5-hydroxyuridine

Controlled Product

CAS: 5168-36-5

Applications 2’-Deoxy-5-hydroxyuridine is involved in the base excision repair (BER) mechanism in mitochondria.
References Gredilla, R., et al.: Methods Mol. Biol., 920, 289-304 (2012)

Formula: C₉H₁₂N₂O₆

Color and Shape: Neat

Molecular weight: 244.201

Ref: TR-D281525

2'-Deoxy-5-hydroxyuridine

CAS: 5168-36-5

2'-Deoxy-5-hydroxyuridine is a hydrated form of uracil that is used in the synthesis of nucleic acids. It is also a substrate for DNA polymerases and has been shown to inhibit the replication of herpes simplex virus. 2'-Deoxy-5-hydroxyuridine has been shown to have biological properties, such as inhibition of radiation-induced transformation, inhibition of cancer cell growth, and antiviral activity. The mechanism by which 2'-deoxy-5-hydroxyuridine inhibits the replication of herpes simplex virus is unclear but may be due to its ability to inhibit cellular metabolism.

Formula: C₉H₁₂N₂O₆

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 244.21 g/mol

Ref: 3D-ND08235

5-OHdU

CAS: 5168-36-5

5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.

Formula: C₉H₁₂N₂O₆

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 244.2

Ref: TM-T19152