CAS 517-09-9

(+)-Equilenin

Description:

(+)-Equilenin is a naturally occurring steroid and a member of the class of compounds known as estrogens. It is primarily derived from the urine of pregnant mares and is often used in hormone replacement therapy. The molecular structure of (+)-Equilenin features a phenolic hydroxyl group, which contributes to its estrogenic activity. This compound exhibits a unique stereochemistry, characterized by its specific optical rotation, which is crucial for its biological activity. As a synthetic derivative of equine estrogens, it is known for its ability to bind to estrogen receptors, influencing various physiological processes such as reproductive health and bone density maintenance. In terms of solubility, (+)-Equilenin is generally more soluble in organic solvents than in water, which affects its formulation in pharmaceutical applications. Safety and efficacy are critical considerations in its use, as with all hormone therapies, necessitating careful monitoring of potential side effects. Overall, (+)-Equilenin plays a significant role in both veterinary and human medicine, particularly in managing menopausal symptoms and other estrogen-related conditions.

Formula: C₁₈H₁₈O₂

InChI: InChI=1S/C18H18O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h2-5,10,16,19H,6-9H2,1H3/t16-,18-/m0/s1

InChI key: InChIKey=PDRGHUMCVRDZLQ-WMZOPIPTSA-N

SMILES: C[C@@]12[C@](C=3C(=C4C(=CC3)C=C(O)C=C4)CC1)(CCC2=O)[H]

Synonyms:

• 3-Hydroxyestra-1,3,5(10),6,8-Pentaen-17-One
• 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one
• E 400
• Equilenin
• Equilenine
• Estra-1,3,5,7,9-pentaen-17-one, 3-hydroxy-
• NSC 9901
• d-Equilenin

Equilenin

CAS: 517-09-9

Equilenin

Purity: 98%

Ref: 54-OR1037095

Equilenin

CAS: 517-09-9

Formula: C₁₈H₁₈O₂

Color and Shape: White To Off-White Solid

Molecular weight: 266.34

Ref: 4Z-E-314

Equilenin

CAS: 517-09-9

Equilenin (E 400) is a natural estrogen that is an endocrine disruptor and has been used in breast cancer research.

Formula: C₁₈H₁₈O₂

Purity: 99.4%

Color and Shape: Solid

Molecular weight: 266.33

Ref: TM-T19776

Equilenin 100 µg/mL in Acetonitrile

CAS: 517-09-9

Formula: C₁₈H₁₈O₂

Color and Shape: Single Solution

Molecular weight: 266.33

Ref: 04-XA13193000AL

Equilenin

CAS: 517-09-9

Applications Equilenin is a naturally occuring estrogenic steroidal hormone (1,2) isolated from urine of pregnant mares (3). Not found in human urine. Component of conjugated estrogenic hormones. Estrogen. This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Corbellini, A. et L.: Farmaco Sci. 1964 Nov;19:913-22.2. Stein, R. et al.: Tetrahedron 1970 Apr;26(8):1917-33.3. Nett, T. et al.: J. Reprod. Fertil. Suppl. 1975 Oct;(23):457-62.

Formula: C₁₈H₁₈O₂

Color and Shape: Light Beige To Light Yellow

Molecular weight: 266.33

Ref: TR-E592400

Equilenin

CAS: 517-09-9

Equilenin is a steroidal estrogen, which is a type of naturally occurring hormone. It is derived primarily from the urine of pregnant mares and belongs to the class of conjugated equine estrogens. In terms of its mode of action, equilenin functions by binding to estrogen receptors in various tissues, thereby modulating gene expression and influencing cellular activity. This interaction supports the management of estrogen deficiencies in postmenopausal women and can influence the regulation of certain metabolic processes.

Formula: C₁₈H₁₈O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 266.33 g/mol

Ref: 3D-FE22774