CAS 517-89-5

Shikonin

Description:

Shikonin, with the CAS number 517-89-5, is a natural compound primarily derived from the roots of the plant Lithospermum erythrorhizon, commonly known as purple gromwell. It is a naphthoquinone derivative, characterized by its deep red to purple color, which is attributed to its conjugated double bond system. Shikonin exhibits a range of biological activities, including anti-inflammatory, antimicrobial, and antioxidant properties, making it of interest in both traditional medicine and modern pharmacology. Its mechanism of action involves the modulation of various signaling pathways, contributing to its therapeutic potential. Additionally, shikonin has been studied for its role in wound healing and skin regeneration, as well as its potential use in cancer therapy due to its ability to induce apoptosis in certain cancer cell lines. The compound is soluble in organic solvents but has limited solubility in water, which can influence its bioavailability and application in formulations. Overall, shikonin represents a significant compound in natural product chemistry with promising applications in health and medicine.

Formula: C₁₆H₁₆O₅

InChI: InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1

InChI key: InChIKey=NEZONWMXZKDMKF-SNVBAGLBSA-N

SMILES: O=C1C=2C(C(=O)C=C1[C@@H](CC=C(C)C)O)=C(O)C=CC2O

Synonyms:

• (R)-(+)-Shikonin
• 1,4-Naphthalenedione 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-
• 1,4-Naphthalenedione, 5,8-Dihydroxy-2-(1-Hydroxy-4-Methyl-3-Penten-1-Yl)-
• 1,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, (R)-
• 1,4-Naphthalenedione, 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-pentenyl]-
• 1,4-Naphthoquinone, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, (+)-
• 5,8-Dihydroxy-2-(1-Hydroxy-4-Methylpent-3-En-1-Yl)Naphthalene-1,4-Dione
• 5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)-1,4-naphthoquinone
• 5,8-Dihydroxy-2-[(1R)-1-Hydroxy-4-Methyl-Pent-3-Enyl]Naphthalene-1,4-Dione
• 5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione
• 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-en-1-yl]naphthalene-1,4-dione
• Isoarnebin 4
• NSC 252844
• Shikonin S
• Shikonine
• Tokyo Violet

5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione

CAS: 517-89-5

Formula: C₁₆H₁₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 288.2952

Ref: IN-DA0037CY

(+)-Shikonin

CAS: 517-89-5

(+)-Shikonin: TMEM16A inhibitor (IC50: 6.5μM), targets PKM2, suppresses NF-κB, inhibits TNF-α, and reduces exosome secretion.

Formula: C₁₆H₁₆O₅

Purity: 98.13% - 99.9%

Color and Shape: Solid

Molecular weight: 288.30

Ref: TM-T1125

Shikonin

CAS: 517-89-5

Shikonin

Color and Shape: Solid

Molecular weight: 288.30g/mol

Ref: 54-BISN0323

(+)-Shikonin

CAS: 517-89-5

(+)-Shikonin

Purity: ≥98%

Molecular weight: 288.3g/mol

Ref: 54-BUP10918

Shikonin

CAS: 517-89-5

Formula: C₁₆H₁₆O₅

Purity: 95%~99%

Molecular weight: 288.299

Ref: BP-BP1302

Shikonin

CAS: 517-89-5

Formula: C₁₆H₁₆O₅

Molecular weight: 288.30

Ref: 7W-GY7466

Shikonin

CAS: 517-89-5

Quinone

Formula: C₁₆H₁₆O₅

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 288.3

Ref: 5G-89791

(R)-(+)-Shikonin

Controlled Product

CAS: 517-89-5

Formula: C₁₆H₁₆O₅

Color and Shape: Neat

Molecular weight: 288.30

Ref: TR-S357600

Shikonin

CAS: 517-89-5

Shikonin is a natural product from the roots of Lithospermum erythroryzon, used in the Chinese herbal medicine under the name Zicao. Shikonin has a broad spectrum of pharmacological activities with antioxidant, anti-inflammatory, antimicrobial, antithrombotic and anti-tumoral properties. Shikonin also has the ability to inhibit the main protease Mpro from coronaviruses, and inhibit the Mpro protease from SARS-CoV-2 with an IC50 of 15.75 μM.

Formula: C₁₆H₁₆O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 288.3 g/mol

Ref: 3D-FS65933

(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione

CAS: 517-89-5

Formula: C₁₆H₁₆O₅

Purity: 95.0%

Molecular weight: 288.299

Ref: 10-F235531