CAS 51744-85-5

(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2S)-piperidin-2-yl]methanol

Description:

(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2S)-piperidin-2-yl]methanol, with the CAS number 51744-85-5, is a chemical compound characterized by its complex structure, which includes a quinoline moiety substituted with two trifluoromethyl groups and a piperidine ring. The presence of the trifluoromethyl groups enhances the lipophilicity and biological activity of the compound, making it of interest in medicinal chemistry. The compound features a chiral center, indicated by the (S) configuration, which can influence its pharmacological properties and interactions with biological targets. As a methanol derivative, it possesses a hydroxyl (-OH) functional group, contributing to its potential solubility in polar solvents. This compound may exhibit various biological activities, including potential applications in drug development, particularly in areas such as neuropharmacology or as a scaffold for synthesizing other bioactive molecules. Its unique structural features and functional groups make it a subject of interest for further research in both synthetic and medicinal chemistry.

Formula: C₁₇H₁₆F₆N₂O

InChI: InChI=1/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2/t12-,15-/m0/s1

SMILES: C1CCN[C@@H](C1)[C@H](c1cc(C(F)(F)F)nc2c1cccc2C(F)(F)F)O

Synonyms:

• 4-quinolinemethanol, alpha-[(2S)-2-piperidinyl]-2,8-bis(trifluoromethyl)-, (alphaS)-

Mefloquine EP Impurity C (as Hydrochloride)

Controlled Product

CAS: 51744-85-5

Formula: C₁₇H₁₆F₆N₂O·HCl

Color and Shape: Neat

Molecular weight: 414.78

Ref: 86-MM1198.03

threo-Mefloquine Hydrochloride

Controlled Product

CAS: 51744-85-5

Applications threo-Mefloquine is a derivative of Mefloquine (M207050), a quinoline methanol antimalarial agent.
References Ding, J. et al.: Angew. Chem. Int. Ed., 52, 8069 (2013); Carroll, F.I., et al.: J. Med. Chem., 17, 210 (1974), Davidson, M.W., et al.: J. Med. Chem., 20, 1117 (1977), Brown, R.E., et al.: Life Sci., et al.: 25, 1857 (1979), Lim, P., et al.: Anal. Profiles Drug Subs., 14, 157 (1985),

Formula: C₁₇H₁₆F₆N₂O·HCl

Color and Shape: Neat

Molecular weight: 414.78

Ref: TR-M207045