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CAS 51756-80-0

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3-Amino-1,4-dideoxy-1,4-dihydro-1,4-dioxorifamycin

Description:
3-Amino-1,4-dideoxy-1,4-dihydro-1,4-dioxorifamycin, with the CAS number 51756-80-0, is a synthetic derivative of rifamycin, a class of antibiotics known for their efficacy against bacterial infections, particularly tuberculosis. This compound features a complex molecular structure characterized by a dioxo group and an amino substituent, which contribute to its biological activity. The presence of the dideoxy configuration indicates modifications that enhance its pharmacological properties. Typically, rifamycins exhibit broad-spectrum antibacterial activity by inhibiting bacterial RNA synthesis through binding to DNA-dependent RNA polymerase. The specific modifications in 3-Amino-1,4-dideoxy-1,4-dihydro-1,4-dioxorifamycin may influence its solubility, stability, and interaction with bacterial targets. As with many antibiotics, the potential for resistance development is a critical consideration in its therapeutic use. Overall, this compound represents an important area of research in antibiotic development, particularly in the context of combating resistant strains of bacteria.
Formula:C37H46N2O12
InChI:InChI=1S/C37H46N2O12/c1-15-11-10-12-16(2)36(47)39-27-26(38)31(44)23-24(32(27)45)30(43)20(6)34-25(23)35(46)37(8,51-34)49-14-13-22(48-9)17(3)33(50-21(7)40)19(5)29(42)18(4)28(15)41/h10-15,17-19,22,28-29,33,41-43H,38H2,1-9H3,(H,39,47)/b11-10+,14-13+,16-12-/t15-,17+,18+,19+,22-,28-,29+,33+,37-/m0/s1
InChI key:InChIKey=SMPJCQGFZSDIHE-GVDHMVJUSA-N
SMILES:O=C1C=2C3=C4C(=O)C(=C(N)C3=O)NC(=O)\C(\C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2C(C)=C4O
Synonyms:
  • 3-Aminorifamycin S
  • 3-Amino-1,4-dideoxy-1,4-dihydro-1,4-dioxorifamycin
  • Rifamycin, 3-amino-1,4-dideoxy-1,4-dihydro-1,4-dioxo-
  • 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
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