CAS 51762-05-1

Cefroxadine

Description:

Cefroxadine is a semi-synthetic antibiotic belonging to the cephalosporin class, specifically designed to combat bacterial infections. It exhibits a broad spectrum of activity against various Gram-positive and some Gram-negative bacteria, making it effective in treating respiratory tract infections, skin infections, and other bacterial diseases. Cefroxadine works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. The compound is typically administered orally and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics include a relatively short half-life, necessitating multiple doses throughout the day to maintain therapeutic levels. Common side effects may include gastrointestinal disturbances, allergic reactions, and, in rare cases, more severe hypersensitivity reactions. As with other antibiotics, the emergence of resistance is a concern, highlighting the importance of appropriate use. Cefroxadine is not commonly used as a first-line treatment due to the availability of newer antibiotics with improved efficacy and safety profiles. Overall, it remains a valuable option in specific clinical scenarios where susceptibility is confirmed.

Formula: C₁₆H₁₉N₃O₅S

InChI: InChI=1S/C16H19N3O5S/c1-24-9-7-25-15-11(14(21)19(15)12(9)16(22)23)18-13(20)10(17)8-5-3-2-4-6-8/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1

InChI key: InChIKey=RDMOROXKXONCAL-UEKVPHQBSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](N)C=3CC=CCC3)=O)C2=O)(SCC1OC)[H]

Synonyms:

• (6R,7R)-7-[[(2R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[amino(cyclohexa-2,5-dien-1-yl)acetyl]amino}-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6S,7S)-7-{[amino(cyclohexa-2,5-dien-1-yl)acetyl]amino}-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(amino-1,4-cyclohexadien-1-ylacetyl)amino]-3-methoxy-8-oxo-, [6R-[6α,7β(R*)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methoxy-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-amino-1,4-cyclohexadien-1-ylacetyl]amino]-3-methoxy-8-oxo-, (6R,7R)-
• Cefroxadine
• Cgp 9000
• Oraspor

Cefroxadine

CAS: 51762-05-1

Cefroxadine: an oral cephalosporin antibiotic, broad-spectrum, bactericidal, effective for acute uncomplicated cystitis.

Formula: C₁₆H₁₉N₃O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 365.4

Ref: TM-T21461