CAS 51773-92-3

Mefloquine hydrochloride

Description:

Mefloquine hydrochloride is an antimalarial medication primarily used for the prevention and treatment of malaria, particularly in areas where resistance to other antimalarial drugs is prevalent. It is a synthetic compound belonging to the class of quinolines and is characterized by its ability to interfere with the growth of the malaria parasite within red blood cells. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in oral form. Mefloquine hydrochloride has a relatively long half-life, allowing for once-weekly dosing in prophylactic regimens. However, it is associated with a range of potential side effects, including neuropsychiatric symptoms, which can limit its use in certain populations. The compound's mechanism of action involves the inhibition of heme polymerization, leading to the accumulation of toxic heme within the parasite. Due to its specific pharmacological profile, mefloquine hydrochloride remains an important option in the global fight against malaria, especially in endemic regions.

Formula: C₁₇H₁₆F₆N₂O·ClH

InChI: InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s2

InChI key: InChIKey=WESWYMRNZNDGBX-HFEUSWDWNA-N

SMILES: C(F)(F)(F)C=1C2=C(C([C@H](O)[C@]3(CCCCN3)[H])=CC(C(F)(F)F)=N2)C=CC1.Cl

Synonyms:

• (2R)-(+/-)-alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
• (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride (1:1)
• 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, hydrochloride (1:1), (αS)-rel-
• 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (αS)-rel-
• 4-Quinolinemethanol, α-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (R*,S*)-
• Loriam
• Mefloquin hydrochloride
• Mefloquine Hcl
• NSC 157387
• Ro 21-5998/001
• Wr 142490
• [2,8-Bis(Trifluoromethyl)Quinolin-4-Yl](Piperidin-2-Yl)Methanol Hydrochloride (1:1)

Mefloquine Hydrochloride

CAS: 51773-92-3, 53230-10-7

Formula: C₁₇H₁₆F₆N₂O·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 414.78

Ref: 3B-M2313

Mefloquine Hydrochloride

CAS: 51773-92-3

Color and Shape: Neat

Ref: 61-FOR1198.00

MEFLOQUINE FOR SYSTEM SUITABILITY CRS

CAS: 51773-92-3

MEFLOQUINE FOR SYSTEM SUITABILITY CRS

Color and Shape: Modified

Ref: 41-Y0002421

MEFLOQUINE HYDROCHLORIDE CRS

CAS: 51773-92-3

MEFLOQUINE HYDROCHLORIDE CRS

Formula: C₁₇H₁₆F₆N₂O

Color and Shape: Added Modified

Molecular weight: 378.3122

Ref: 41-M0253000

Mefloquine Hydrochloride

CAS: 51773-92-3

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₇H₁₆F₆N₂O·HCl

Color and Shape: White Powder

Molecular weight: 378.11668

Ref: 45-1379059

4-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel-

CAS: 51773-92-3

Formula: C₁₇H₁₇ClF₆N₂O

Purity: %

Color and Shape: Solid

Molecular weight: 414.7731

Ref: IN-DA00I991

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.

Formula: C₁₇H₁₇ClF₆N₂O

Purity: 99% - 99.99%

Color and Shape: Off-White To Yellow Solid

Molecular weight: 414.77

Ref: TM-T0860

(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride

CAS: 51773-92-3

(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride

Formula: C₁₇H₁₆F₆N₂O·ClH

Purity: 99%

Color and Shape: white powder

Molecular weight: 414.77g/mol

Ref: 54-PC404546

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine hydrochloride

Purity: ≥98%

Molecular weight: 414.77g/mol

Ref: 54-BUP13994

Mefloquine HCl

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·HCl

Molecular weight: 378.32 36.46

Ref: 4Z-M-821

Mefloquine hydrochloride, BP, Ph. Eur., USP grade

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·HCl

Molecular weight: 414.77

Ref: 7W-GP0681

Mefloquine hydrochloride

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·HCl

Purity: ≥ 98.0%

Color and Shape: White to pale yellow crystalline powder

Molecular weight: 414.77

Ref: 7W-GP7880

Mefloquine hydrochloride 100 µg/mL in Acetonitrile

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·ClH

Color and Shape: Single Solution

Molecular weight: 414.77

Ref: 04-A14860900AL-100

Mefloquine Hydrochloride

CAS: 51773-92-3

Formula: C₁₇H₁₆F₆N₂O·ClH

Color and Shape: Neat

Molecular weight: 414.77

Ref: 86-MM1198.00

Mefloquine Hydrochloride (d10 Major)

Controlled Product

CAS: 51773-92-3

Applications Labelled quinoline methanol antimalarial agent.
References Carroll, F.I., et al.: J. Med. Chem., 17, 210 (1974), Davidson, M.W., et al.: J. Med. Chem., 20, 1117 (1977), Brown, R.E., et al.: Life Sci., et al.: 25, 1857 (1979), Lim, P., et al.: Anal. Profiles Drug Subs., 14, 157 (1985),

Formula: C₁₇₂H₁₀H₆F₆N₂O·ClH

Color and Shape: Neat

Molecular weight: 424.83

Ref: TR-M207053

Mefloquine hydrochloride

CAS: 51773-92-3

Mefloquine is a drug that belongs to the class of pharmacological agents. It is used in the treatment of malaria caused by protozoa of the genus Plasmodium, which are transmitted by mosquitoes. Mefloquine is a metal chelate that inhibits the activity of p-glycoprotein, a membrane protein which controls the transport or efflux of many drugs from cells. This inhibition leads to an increase in the concentration of mefloquine inside bacteria and parasites, increasing its effectiveness at inhibiting their growth. Mefloquine has been shown to be effective in treating infectious diseases such as bowel disease and malaria caused by protozoa.
Mefloquine can cause toxic epidermal necrolysis, a condition where large areas of skin slough off and die if taken with certain other drugs (such as phenytoin).

Formula: C₁₇H₁₇ClF₆N₂O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 414.77 g/mol

Ref: 3D-FP40600

Mefloquine hydrochloride

CAS: 51773-92-3

Formula: C₁₇H₁₇ClF₆N₂O

Purity: 95.0%

Molecular weight: 414.78

Ref: 10-F091687