CAS 51773-92-3
:Mefloquine hydrochloride
Description:
Mefloquine hydrochloride is an antimalarial medication primarily used for the prevention and treatment of malaria, particularly in areas where resistance to other antimalarial drugs is prevalent. It is a synthetic compound belonging to the class of quinolines and is characterized by its ability to interfere with the growth of the malaria parasite within red blood cells. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in oral form. Mefloquine hydrochloride has a relatively long half-life, allowing for once-weekly dosing in prophylactic regimens. However, it is associated with a range of potential side effects, including neuropsychiatric symptoms, which can limit its use in certain populations. The compound's mechanism of action involves the inhibition of heme polymerization, leading to the accumulation of toxic heme within the parasite. Due to its specific pharmacological profile, mefloquine hydrochloride remains an important option in the global fight against malaria, especially in endemic regions.
Formula:C17H16F6N2O·ClH
InChI:InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s2
InChI key:InChIKey=WESWYMRNZNDGBX-HFEUSWDWNA-N
SMILES:C(F)(F)(F)C=1C2=C(C([C@H](O)[C@]3(CCCCN3)[H])=CC(C(F)(F)F)=N2)C=CC1.Cl
Synonyms:- (2R)-(+/-)-alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
- (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride (1:1)
- 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, hydrochloride (1:1), (αS)-rel-
- 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (αS)-rel-
- 4-Quinolinemethanol, α-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (R*,S*)-
- Loriam
- Mefloquin hydrochloride
- Mefloquine Hcl
- NSC 157387
- Ro 21-5998/001
- Wr 142490
- [2,8-Bis(Trifluoromethyl)Quinolin-4-Yl](Piperidin-2-Yl)Methanol Hydrochloride (1:1)
- See more synonyms
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Found 17 products.
Mefloquine Hydrochloride
CAS:Formula:C17H16F6N2O·HClPurity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:414.78MEFLOQUINE FOR SYSTEM SUITABILITY CRS
CAS:MEFLOQUINE FOR SYSTEM SUITABILITY CRSColor and Shape:ModifiedMEFLOQUINE HYDROCHLORIDE CRS
CAS:MEFLOQUINE HYDROCHLORIDE CRSFormula:C17H16F6N2OColor and Shape:Added ModifiedMolecular weight:378.3122Mefloquine Hydrochloride
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFormula:C17H16F6N2O·HClColor and Shape:White PowderMolecular weight:378.116684-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel-
CAS:Formula:C17H17ClF6N2OPurity:%Color and Shape:SolidMolecular weight:414.7731Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurity:99% - 99.99%Color and Shape:Off-White To Yellow SolidMolecular weight:414.77(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride
CAS:<p>(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride</p>Formula:C17H16F6N2O·ClHPurity:99%Color and Shape: white powderMolecular weight:414.77g/molMefloquine hydrochloride
CAS:Formula:C17H16F6N2O·HClPurity:≥ 98.0%Color and Shape:White to pale yellow crystalline powderMolecular weight:414.77Mefloquine hydrochloride 100 µg/mL in Acetonitrile
CAS:Formula:C17H16F6N2O·ClHColor and Shape:Single SolutionMolecular weight:414.77Mefloquine Hydrochloride (d10 Major)
CAS:Controlled Product<p>Applications Labelled quinoline methanol antimalarial agent.<br>References Carroll, F.I., et al.: J. Med. Chem., 17, 210 (1974), Davidson, M.W., et al.: J. Med. Chem., 20, 1117 (1977), Brown, R.E., et al.: Life Sci., et al.: 25, 1857 (1979), Lim, P., et al.: Anal. Profiles Drug Subs., 14, 157 (1985),<br></p>Formula:C172H10H6F6N2O·ClHColor and Shape:NeatMolecular weight:424.83Mefloquine hydrochloride
CAS:<p>Mefloquine is a drug that belongs to the class of pharmacological agents. It is used in the treatment of malaria caused by protozoa of the genus Plasmodium, which are transmitted by mosquitoes. Mefloquine is a metal chelate that inhibits the activity of p-glycoprotein, a membrane protein which controls the transport or efflux of many drugs from cells. This inhibition leads to an increase in the concentration of mefloquine inside bacteria and parasites, increasing its effectiveness at inhibiting their growth. Mefloquine has been shown to be effective in treating infectious diseases such as bowel disease and malaria caused by protozoa.<br>Mefloquine can cause toxic epidermal necrolysis, a condition where large areas of skin slough off and die if taken with certain other drugs (such as phenytoin).</p>Formula:C17H17ClF6N2OPurity:Min. 95%Color and Shape:White PowderMolecular weight:414.77 g/mol
![(S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol hydrochloride](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FPC404546.jpg&w=3840&q=75)
