CymitQuimica logo

CAS 51795-47-2

:

Paromomycin II

Description:
Paromomycin II is an aminoglycoside antibiotic derived from the bacterium Micromonospora paromomycinus. It is primarily used in the treatment of certain parasitic infections, particularly leishmaniasis and amebiasis. The compound exhibits a broad spectrum of antimicrobial activity, particularly against Gram-negative bacteria and some protozoa. Paromomycin II functions by binding to the 30S ribosomal subunit, inhibiting protein synthesis, which ultimately leads to bacterial cell death. Its chemical structure features multiple amino groups, contributing to its solubility and interaction with bacterial ribosomes. Paromomycin is generally administered orally or parenterally, depending on the infection being treated. While it is effective, it can also have side effects, including nephrotoxicity and ototoxicity, which necessitate careful monitoring during treatment. Additionally, resistance to aminoglycosides can develop, making susceptibility testing important in clinical settings. Overall, Paromomycin II is a valuable therapeutic agent in specific infectious diseases, with its use guided by clinical considerations and potential side effects.
Formula:C23H45N5O14
InChI:InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7-,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChI key:InChIKey=UOZODPSAJZTQNH-VZXHOKRSSA-N
SMILES:O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N
Synonyms:
  • Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-
  • D-Streptamine, O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
  • O-2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine
  • D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-
  • Paromomycin II
Sort by
The purity filter is not visible because current products do not have associated purity data for filtering.
Found 3 products.