CAS 51798-45-9

Elastatinal

Description:

Elastatinal is a chemical compound classified as a cyclic peptide, specifically a member of the elastase inhibitors. It is derived from natural sources, particularly from certain species of fungi. The compound exhibits notable biological activity, primarily as an inhibitor of elastase, an enzyme that breaks down elastin, a key protein in connective tissues. This inhibition can have implications in various physiological processes and potential therapeutic applications, particularly in conditions characterized by excessive elastase activity, such as chronic obstructive pulmonary disease (COPD) and certain inflammatory disorders. Elastatinal is characterized by its unique cyclic structure, which contributes to its stability and specificity in binding to elastase. Additionally, it has been studied for its potential role in drug development due to its ability to modulate proteolytic activity. As with many bioactive compounds, further research is necessary to fully understand its mechanisms of action, pharmacokinetics, and potential side effects in clinical settings.

Formula: C₂₁H₃₆N₈O₇

InChI: InChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

InChI key: InChIKey=IJWCGVPEDDQUDE-YGJAXBLXSA-N

SMILES: [C@H](C(N[C@H](C(N[C@H](C=O)C)=O)CCC(N)=O)=O)(NC(N[C@@H](CC(C)C)C(O)=O)=O)[C@]1(NC(N)=NCC1)[H]

Synonyms:

• (2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-<span class="text-smallcaps">L</span>-glutamamide
• (2S,6S,9S,12S)-9-(3-amino-3-oxopropyl)-6-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• (2S,9S)-9-(3-amino-3-oxopropyl)-6-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• 9-(3-Amino-3-Oxopropyl)-6-(2-Amino-3,4,5,6-Tetrahydropyrimidin-4-Yl)-12-Methyl-2-(2-Methylpropyl)-4,7,10,13-Tetraoxo-3,5,8,11-Tetraazatridecan-1-Oic Acid (Non-Preferred Name)
• <span class="text-smallcaps">L</smallcap>-Glutamamide, <smallcap>L</span>-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N¹-(1-methyl-2-oxoethyl)-, stereoisomer
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• Elastatinal
• N~2~-[(2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-2-({[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}amino)acetyl]-N~1~-[(2S)-1-oxopropan-2-yl]-L-glutamamide
• L-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-, stereoisomer

Elastatinal

CAS: 51798-45-9

Formula: C₂₁H₃₆N₈O₇

Purity: 85%

Molecular weight: 512.5599

Ref: IN-DA01E4MS

Elastatinal

CAS: 51798-45-9

Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.

Formula: C₂₁H₃₆N₈O₇

Color and Shape: Yellowish Solid

Molecular weight: 512.56

Ref: TM-T20130

Elastatinal microbial

CAS: 51798-45-9

Formula: C₂₁H₃₆N₈O₇

Purity: ~0.64μg/ml (IC50, pH8.8, 37°C)

Color and Shape: White to light-yellow or tan powder

Molecular weight: 512.60

Ref: 7W-GL1320

Elastatinal

Controlled Product

CAS: 51798-45-9

Applications Elastatinal is an elastase inhibitor.

Formula: C₂₁H₃₆N₈O₇

Color and Shape: Neat

Molecular weight: 512.56

Ref: TR-E501008

Elastatinal

CAS: 51798-45-9

Elastatinal is a research tool that is used to activate cells by binding to a receptor on the cell surface. Elastatinal belongs to the Ligand class of compounds and has been shown to bind to various ion channels and receptors, including cell surface receptors. This ligand binds with high affinity to the α-adrenergic receptor (α-AR) and activates cells that express this receptor. It also inhibits the binding of other ligands, such as bradykinin, which may be useful in pharmacology. Elastatinal is an inhibitor of protein interactions, which can be used in Cell Biology studies.

Formula: C₂₁H₃₆N₈O₇

Purity: Min. 95%

Molecular weight: 512.56 g/mol

Ref: 3D-IEL-4064-V

Elastatinal

CAS: 51798-45-9

Irreversible elastase inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formula: C₂₁H₃₆N₈O₇

Molecular weight: 512.6

Ref: 02-J61120

Elastatinal

CAS: 51798-45-9

Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and vaginal secretions. Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and

Formula: C₂₁H₃₆N₈O₇

Purity: Min. 95%

Molecular weight: 512.56 g/mol

Ref: 3D-IEL-4064