CAS 518-28-5
:Podophyllotoxin
Description:
Podophyllotoxin is a naturally occurring lignan derived from the roots of the mayapple plant, *Podophyllum peltatum*. It is characterized by its complex polycyclic structure, which includes a dibenzylbutyrolactone skeleton. This compound exhibits significant biological activity, particularly as an antitumor agent, and has been utilized in the treatment of various cancers, including testicular cancer and certain types of skin lesions. Podophyllotoxin functions by inhibiting the enzyme topoisomerase II, which is crucial for DNA replication and cell division, thereby leading to cell death in rapidly dividing cancer cells. Additionally, it possesses antiviral properties, particularly against human papillomavirus (HPV), making it useful in topical treatments for warts. The substance is typically found in a crystalline form and is soluble in organic solvents but has limited solubility in water. Due to its potent biological effects, podophyllotoxin is handled with care in laboratory and clinical settings, and its derivatives, such as etoposide and teniposide, are more commonly used in chemotherapy regimens.
Formula:C22H22O8
InChI:InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
InChI key:InChIKey=YJGVMLPVUAXIQN-XVVDYKMHSA-N
SMILES:O=C1[C@@]2([C@@H](C=3C([C@H](O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(OC)C(OC)=C5)[H]
Synonyms:- (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
- (5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
- 1,3,3A,4,9,9A-Hexahidro-9-Hidroxi-6,7-(Metilenodioxi)-4-(3',4',5'-Trimetoxifenil)Benzo[F]Isobenzofuran-3-Ona
- 1,3,3A,4,9,9A-Hexahydro-9-Hydroxy-6,7-(Methylenedioxy)-4-(3',4',5'-Trimethoxyphenyl)Benz[F]Isobenzofuran-3-One
- 1,3,3A,4,9,9A-Hexahydro-9-Hydroxy-6,7-(Methylenedioxy)-4-(3',4',5'-Trimethoxyphenyl)Benzo[F]Isobenzofuranne-3-One
- 1,3,3a,4,9,9a-Hexahydro-9-hydroxy-6,7-(methylendioxy)-4-(3',4',5'-trimethoxyphenyl)benz[f]isobenzofuran-3-on
- 9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
- Condyline
- Condylox
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9R)-
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5α,5aβ,8aα,9α)]-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9R)-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5α,5aβ,8aα,9α)]-
- Nsc 24818
- Podofilox
- See more synonyms
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Found 17 products.
Podophyllotoxin
CAS:Formula:C22H22O8Purity:>95.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:414.41(-)-Podophyllotoxin
CAS:(-)-Podophyllotoxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.Formula:C22H22O8Purity:(HPLC) ≥98%Color and Shape:PowderMolecular weight:414.42PODOPHYLLOTOXIN FOR SYSTEM SUITABILITY CRS
CAS:PODOPHYLLOTOXIN FOR SYSTEM SUITABILITY CRSColor and Shape:Crystalline Powder(10R,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one
CAS:Formula:C22H22O8Purity:98%Color and Shape:SolidMolecular weight:414.4053Ref: IN-DA003ACJ
1g25.00€5g49.00€1kgTo inquire25g110.00€5kgTo inquire100g285.00€500gTo inquire250mg25.00€Podofilox
CAS:Podofilox, a toxic spindle poison from Podophyllum roots, treats warts and keratoses, irritates skin, and may fight cancer.
Formula:C22H22O8Purity:98% - 99.73%Color and Shape:Solvated Crystals SolidMolecular weight:414.41Podophyllotoxin-d6
CAS:Formula:C22H16D6O8Color and Shape:White To Off-White SolidMolecular weight:420.45Podophyllotoxin
CAS:LactoneFormula:C22H22O8Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:414.41Podophyllotoxin
CAS:Controlled ProductStability Very Hygroscopic
Applications Skin treatment for genital warts caused by some types of HPVs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kelly, M.G. & Hartwell, J.L.; J. of the Nat'l Cancer Inst., 14, 967 (1954), Gupta, R.S.; Somatic Cell Genetics, 7, 59 (1981), Gupta, R.S.; Cancer Research, 43, 505 (1983a)Formula:C22H22O8Color and Shape:White To Off-WhiteMolecular weight:414.41Podophyllotoxin
CAS:Podophyllotoxin is a potent antimitotic agent, which is derived from the roots and rhizomes of plants belonging to the genus Podophyllum, such as Podophyllum peltatum and Podophyllum emodi. Its mode of action involves the inhibition of microtubule assembly, leading to the disruption of mitotic spindle formation during cell division. This results in the arrest of cell proliferation, making it particularly effective against rapidly dividing cells.Formula:C22H22O8Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:414.41 g/mol
