CAS 518-34-3

Tetrandrine

Description:

Tetrandrine is a bisbenzylisoquinoline alkaloid primarily derived from the plant *Stephania tetrandra*, which is traditionally used in Chinese medicine. It is characterized by its complex structure, featuring two benzylisoquinoline units linked by a carbon chain. Tetrandrine exhibits a range of biological activities, including anti-inflammatory, anti-cancer, and anti-arrhythmic properties. It has been studied for its potential to modulate calcium channels, which can influence various physiological processes. The compound is typically found as a white to off-white crystalline powder and is soluble in organic solvents but has limited solubility in water. Tetrandrine's pharmacological effects are attributed to its ability to interact with multiple cellular pathways, making it a subject of interest in both traditional and modern medicinal research. However, its use may be associated with side effects, necessitating careful consideration in therapeutic applications. As with any bioactive compound, further studies are essential to fully understand its mechanisms and potential clinical uses.

Formula: C₃₈H₄₂N₂O₆

InChI: InChI=1/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29?,30-/m0/s1

InChI key: InChIKey=WVTKBKWTSCPRNU-KYJUHHDHSA-N

SMILES: O(C)C1=C2C=3[C@](CC=4C=C(C(OC)=CC4)OC=5C=CC(C[C@]6(C7=CC(O2)=C(OC)C=C7CCN6C)[H])=CC5)(N(C)CCC3C=C1OC)[H]

Synonyms:

• (+)-Tetrandrine
• (1Beta)-6,6',7,12-Tetramethoxy-2,2'-Dimethylberbaman
• (1Beta,1'Xi)-6,6',7,12-Tetramethoxy-2,2'-Dimethylberbaman
• (4aS,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline
• 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-
• 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, [4aS-(4aR*,16aR*)]-
• 6,6',7,12-Tetramethoxy-2,2'-dimethyl-1-beta-berbaman
• Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1beta)-
• Berbaman, 6,6′,7,12-tetramethoxy-2,2′-dimethyl-, (1β)-
• D-Tetrandrine
• Fanchinine
• Hanfangchin A
• NSC 77037
• Sinomenine A
• Tetrandrin
• Conba
• (S,S)-(+)-TETRANDRINE
• (S S)-(+)-TETRANDRINE 98%
• TETRANDRINE, (S,S)-(+)-(RG)
• 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline,3,4,4a,5, 16a,17,18,19-octahydro-12,21,22,26-
• TETRANDRINE, (S,S)-(+)
• 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)-
• Tetrandrine(Fanchinine,NSC 77037)
• 6,6',7,12-TETRAMETHOXY-2,2'-DIMETHYLBERBAMAN
• Tetrandrine(Fanchinine)
• Jinake
• Trandrine
• 6’,7,12-tetramethoxy-2,2’-dimethyl-(1-beta)-berbama
• tetramethoxy-4,17-dimethyl-,(4aS,16aS)-
• (1B)-6,6',7,12-TETRAMETHOXY-2,2'-DIMETHYLBERBAMAN
• (1β)-6,6',7,12-tetramethoxy-2,2'-dimethylberbaman
• 6,6',7,12-Tetramethoxy-2,2'-dimethyl-9',10',11',12',13',14'-hexadehydro-9',10',11',12',13',14'-hexahydroberbaman

Tetrandrine

CAS: 518-34-3

Formula: C₃₈H₄₂N₂O₆

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 622.76

Ref: 3B-T3321

TETRANDRINE CRS

CAS: 518-34-3

TETRANDRINE CRS

Formula: C₃₈H₄₂N₂O₆

Molecular weight: 622.7499

Ref: 41-Y0001165

(+)-TETRANDRINE

CAS: 518-34-3

Formula: C₃₈H₄₂N₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 622.7499

Ref: IN-DA00390G

(S,S)-(+)-Tetrandrine

CAS: 518-34-3

(S,S)-(+)-Tetrandrine

Purity: 95%

Molecular weight: 622.75g/mol

Ref: 54-OR1028246

Tetrandrine

CAS: 518-34-3

Formula: C₃₈H₄₂N₂O₆

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 622.75

Ref: 7W-GP2274

Tetrandrine

CAS: 518-34-3

Tetrandrine

Purity: ≥98%

Molecular weight: 622.75g/mol

Ref: 54-BUP16790

Tetrandrine

CAS: 518-34-3

Tetrandrine is a calcium channel blocker, which shows antitumor, antifibrotic, anti-oxidant, anti-inflammatory and immunosuppressive activity. It suppressed Wnt/β-catenin signaling transduction, the migration of DU145 and PC-3 cells, EOMA cell growth through the ROS/Akt pathway and inhibited inward rectifying potassium current in cultured bovine aortic endothelial cells.

Formula: C₃₈H₄₂N₂O₆

Purity: 95%~99%

Molecular weight: 622.762

Ref: BP-BP1379

Tetrandrine

CAS: 518-34-3

Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.

Formula: C₃₈H₄₂N₂O₆

Purity: 99.61% - 99.94%

Color and Shape: White Solid

Molecular weight: 622.75

Ref: TM-T2996

Tetrandrine

CAS: 518-34-3

Natural alkaloid

Formula: C₃₈H₄₂N₂O₆

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 622.76

Ref: 5G-89321

Tetrandrine

CAS: 518-34-3

Non-selective calcium channel blocker

Formula: C₃₈H₄₂N₂O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 622.75 g/mol

Ref: 3D-FT08803

Tetrandrine

CAS: 518-34-3

M02568 - Tetrandrine

Formula: C₃₈H₄₂N₂O₆

Purity: 98%

Molecular weight: 622.762

Ref: 10-M02568

Tetrandrine

Controlled Product

CAS: 518-34-3

Applications Tetrandrine is a lipopolysaccharide-induced microglial suppressor, effectively reducing the production of bacterial inflammatory mediators. Anti-inflammatory, anti-nociceptive. Tetrandrine is used in China to treat high blood pressure. This drug blocked the TPC2 calcium channel required for the Ebola infection process (Robert A. Davey et al., Science 2015, DOI: 10.1126/science.1258758).
References Yalong, D. et al.: PLoS One. 9, e102522 (2014); Westra, I. et al.: PLoS One., 9, e95462 (2014); Chem. and Eng. News, 93 (9) 8 Mar.2 (2015)

Formula: C₃₈H₄₂N₂O₆

Color and Shape: Light Yellow Solid

Molecular weight: 622.75

Ref: TR-T305785