CAS 51888-09-6

Prochlorperazine dimethanesulfonate

Description:

Prochlorperazine dimethanesulfonate is a pharmaceutical compound primarily used as an antipsychotic and antiemetic agent. It is a salt form of prochlorperazine, which belongs to the class of phenothiazines. This compound exhibits properties that help in the treatment of severe nausea and vomiting, as well as in managing psychotic disorders. Prochlorperazine dimethanesulfonate is characterized by its ability to antagonize dopamine receptors in the central nervous system, which contributes to its therapeutic effects. The dimethanesulfonate moiety enhances the solubility and stability of the drug, making it suitable for various formulations, including oral and injectable forms. The compound is typically administered under medical supervision due to potential side effects, which may include sedation, extrapyramidal symptoms, and anticholinergic effects. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are essential for its efficacy and safety profile. Overall, prochlorperazine dimethanesulfonate is a valuable medication in clinical settings, particularly for patients requiring management of severe nausea or psychotic symptoms.

Formula: C₂₀H₂₄ClN₃S·2CH₄O₃S

InChI: InChI=1S/C20H24ClN3S.CH4O3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;1-5(2,3)4/h2-3,5-8,15H,4,9-14H2,1H3;1H3,(H,2,3,4)

InChI key: InChIKey=WLFCZUKGFJNFQY-UHFFFAOYSA-N

SMILES: S(C)(=O)(=O)O.C(CCN1CCN(C)CC1)N2C=3C(SC=4C2=CC=CC4)=CC=C(Cl)C3

Synonyms:

• 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-, dimethanesulfonate
• 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-, methanesulfonate (1:2)
• 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
• 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine methanesulfonate (1:2)
• Novamin
• Novamin (neuroleptic)
• Prochloroperazine compound with methanesulfonic acid (1:2)
• Prochlorperazine bismethanesulfonate
• Prochlorperazine dimethanesulfonate
• Prochlorperazine methanesulfonate
• Unii-531Sh87H9N

Prochlorperazine Dimesylate

Controlled Product

CAS: 51888-09-6

Applications Antiemetic, antipsychotic; used in treatment of vertigo.
References Taylor, W.B., et al.: Br. J. Clin. Pharmacol., 23, 137 (1987), Ward, A.E., Br. J. Clin. Pract., 42, 228 (1988),

Formula: C₂₀H₂₄ClN₃SCH₃SO₃H

Color and Shape: Neat

Molecular weight: 566.15

Ref: TR-P755800

Prochlorperazine-d3 Dimesylate

Controlled Product

CAS: 51888-09-6, 753432-54-1

Applications Antiemetic, antipsychotic; used in treatment of vertigo.
References Taylor, W.B., et al.: Br. J. Clin. Pharmacol., 23, 137 (1987), Ward, A.E., Br. J. Clin. Pract., 42, 228 (1988),

Formula: C₂₀H₂₁D₃ClN₃S•2CH₃SO₃H

Color and Shape: Neat

Molecular weight: 376.9629611

Ref: TR-P755802