CAS 52-01-7
:Spironolactone
Description:
Spironolactone is a synthetic steroidal compound primarily used as a diuretic and antihypertensive agent. It functions as an aldosterone antagonist, inhibiting the action of aldosterone in the kidneys, which promotes sodium and water excretion while conserving potassium. This mechanism makes it effective in treating conditions such as hypertension, heart failure, and certain cases of edema. Spironolactone is also utilized in the management of conditions like hyperaldosteronism and can be beneficial in treating acne and hirsutism due to its anti-androgenic properties. The compound is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in many cases. In terms of its chemical structure, spironolactone features a lactone ring and a thioester group, contributing to its pharmacological activity. Common side effects may include hyperkalemia, gastrointestinal disturbances, and hormonal imbalances. Due to its hormonal effects, spironolactone is sometimes used off-label in hormone therapy for transgender individuals. Overall, spironolactone is a versatile medication with significant therapeutic applications in various medical conditions.
Formula:C24H32O4S
InChI:InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
InChI key:InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N
SMILES:C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3
Synonyms:- (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone
- 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
- 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate
- 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate
- 3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone
- 3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone
- 3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone
- 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-
- 7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
- 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone
- Abbolactone
- Aldace
- Aldactone
- Aldactone A
- Aldopur
- Almatol
- Altex
- Aquareduct
- Berlactone
- Deverol
- Diatensec
- Dira
- Duraspiron
- Espironolactona
- Euteberol
- Lacalmin
- Lacdene
- Laractone
- Nefurofan
- Novo-Spiroton
- Nsc 150399
- Osiren
- Osyrol
- Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-
- Quimolactona
- S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate
- S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
- S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
- Sagisal
- Sc 9420
- Sincomen
- Spiresis
- Spiretic
- Spiridon
- Spiro-Tablinen
- Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.
- Spiroctan
- Spiroderm
- Spirolactone
- Spirolang
- Spirolone
- Spirone
- Spironol
- Spironolacton
- Spironolactone A
- Supra-Puren
- Suracton
- Uractone
- Urusonin
- Verospiron
- Verospirone
- Xenalon
- See more synonyms
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Found 27 products.
Spironolactone
CAS:Formula:C24H32O4SPurity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:416.58Spironolactone
CAS:<p>Spironolactone used as potassium sparing diuretic. Also used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation</p>Formula:C24H32O4SColor and Shape:White solidMolecular weight:416.58SPIRONOLACTONE CRS
CAS:SPIRONOLACTONE CRSFormula:C24H32O4SColor and Shape:PowderMolecular weight:416.5735SPIRONOLACTONE RS
CAS:SPIRONOLACTONE RSFormula:C24H32O4SColor and Shape:PowderMolecular weight:416.5735Spironolactone
CAS:SpironolactoneFormula:C24H32O4SPurity:99.3%Color and Shape:Off-WhiteMolecular weight:416.20213SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS
CAS:SPIRONOLACTONE FOR SYSTEM SUITABILITY CRSColor and Shape:PowderSpironolactone
CAS:Adrenal cortical hormones and their derivatives nesoiFormula:C24H32O4SColor and Shape:White Light Cream PowderMolecular weight:416.20213Spironolactone
CAS:Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.Formula:C24H32O4SPurity:99.87%Color and Shape:White PowderMolecular weight:416.57Spironolactone, Ph. Eur. grade
CAS:Formula:C24H32O4SPurity:≤ 0.1%Color and Shape:White or pale yellow powderMolecular weight:416.58Spironolactone
CAS:Formula:C24H32O4SPurity:(HPLC) ≥ 97.0%Color and Shape:White to off-white powderMolecular weight:416.58Spironolactone-d3 (Major)
CAS:Formula:C24H29D3O4SColor and Shape:Off-White To Pale Yellow SolidMolecular weight:419.59Sugammadex Impurity 77
CAS:Formula:C87H114O48PS7·7NaColor and Shape:Off-White To Pale Yellow SolidMolecular weight:2183.22 7*22.99Spironolactone-d3
CAS:Controlled Product<p>Applications Spironolactone-d3 is the labeled analogue of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.<br>References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975)<br></p>Formula:C24H29D3O4SColor and Shape:Yellow SolidMolecular weight:419.59Spironolactone
CAS:Controlled Product<p>Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.<br>References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),<br></p>Formula:C24H32O4SColor and Shape:Off-WhiteMolecular weight:416.57Spironolactone-d7 (Major)
CAS:Controlled Product<p>Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. A representative lot was 19% d3; 47% d6; 12% d7; 7% d8; 3% d9; 3% d10 and 8% d11.<br>References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),<br></p>Formula:C24H25D7O4SColor and Shape:NeatMolecular weight:423.62Spironolactone
CAS:Controlled Product<p>Mineralocorticoid (aldosterone) receptor antagonist; anti-hypertensive</p>Formula:C24H32O4SPurity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:416.57 g/molSpironolactone - Bio-X ™
CAS:Controlled Product<p>Spironolactone is an aldosterone receptor antagonist that is used to treat hypertension, heart failure and edema. This drug binds to mineralocorticoid receptors and acts as an aldosterone antagonist. Spironolactone promotes sodium and water excretion and potassium retention. It also activates pro-inflammatory pathways.</p>Formula:C24H32O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:416.57 g/molSpironolactone extrapure, 97%
CAS:Formula:C24H32O4SPurity:min. 97%Color and Shape:White, PowderMolecular weight:416.6017-Hydroxy-7-α-mercapto-3-oxo-17-α-pregn-4-ene-21-carboxylic acid-γ-lactone-7-acetate
CAS:Formula:C24H32O4SPurity:97%Color and Shape:SolidMolecular weight:416.5735
