CAS 52-01-7

Spironolactone

Description:

Spironolactone is a synthetic steroidal compound primarily used as a diuretic and antihypertensive agent. It functions as an aldosterone antagonist, inhibiting the action of aldosterone in the kidneys, which promotes sodium and water excretion while conserving potassium. This mechanism makes it effective in treating conditions such as hypertension, heart failure, and certain cases of edema. Spironolactone is also utilized in the management of conditions like hyperaldosteronism and can be beneficial in treating acne and hirsutism due to its anti-androgenic properties. The compound is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in many cases. In terms of its chemical structure, spironolactone features a lactone ring and a thioester group, contributing to its pharmacological activity. Common side effects may include hyperkalemia, gastrointestinal disturbances, and hormonal imbalances. Due to its hormonal effects, spironolactone is sometimes used off-label in hormone therapy for transgender individuals. Overall, spironolactone is a versatile medication with significant therapeutic applications in various medical conditions.

Formula: C₂₄H₃₂O₄S

InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

InChI key: InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N

SMILES: C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3

Synonyms:

• (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone
• 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
• 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate
• 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate
• 3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone
• 3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone
• 3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone
• 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-
• 7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
• 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone
• Abbolactone
• Aldace
• Aldactone
• Aldactone A
• Aldopur
• Almatol
• Altex
• Aquareduct
• Berlactone
• Deverol
• Diatensec
• Dira
• Duraspiron
• Espironolactona
• Euteberol
• Lacalmin
• Lacdene
• Laractone
• Nefurofan
• Novo-Spiroton
• Nsc 150399
• Osiren
• Osyrol
• Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-
• Quimolactona
• S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate
• S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• Sagisal
• Sc 9420
• Sincomen
• Spiresis
• Spiretic
• Spiridon
• Spiro-Tablinen
• Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.
• Spiroctan
• Spiroderm
• Spirolactone
• Spirolang
• Spirolone
• Spirone
• Spironol
• Spironolacton
• Spironolactone A
• Supra-Puren
• Suracton
• Uractone
• Urusonin
• Verospiron
• Verospirone
• Xenalon

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 416.58

Ref: 3B-S0260

Spironolactone

CAS: 52-01-7

Spironolactone used as potassium sparing diuretic. Also used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation

Formula: C₂₄H₃₂O₄S

Color and Shape: White solid

Molecular weight: 416.58

Ref: 02-J60119

SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS

CAS: 52-01-7

SPIRONOLACTONE FOR SYSTEM SUITABILITY CRS

Color and Shape: Powder

Ref: 41-Y0001295

SPIRONOLACTONE RS

CAS: 52-01-7

SPIRONOLACTONE RS

Formula: C₂₄H₃₂O₄S

Color and Shape: Powder

Molecular weight: 416.5735

Ref: 41-ICRS49241

SPIRONOLACTONE CRS

CAS: 52-01-7

SPIRONOLACTONE CRS

Formula: C₂₄H₃₂O₄S

Color and Shape: Powder

Molecular weight: 416.5735

Ref: 41-S1200000

Spironolactone

CAS: 52-01-7

Spironolactone

Formula: C₂₄H₃₂O₄S

Purity: 99.3%

Color and Shape: Off-White

Molecular weight: 416.20213

Ref: 47-306

Spironolactone

CAS: 52-01-7

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₄H₃₂O₄S

Color and Shape: White Light Cream Powder

Molecular weight: 416.57

Ref: 45-1619006

Spironolactone

CAS: 52-01-7

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Formula: C₂₄H₃₂O₄S

Purity: 99.87%

Color and Shape: White Powder

Molecular weight: 416.57

Ref: TM-T0476

Spironolactone-d3 (7-Acetylthio-d3)

CAS: 52-01-7

Formula: C₂₄H₂₉D₃O₄S

Molecular weight: 419.59

Ref: 4Z-S-0823

Spironolactone

CAS: 52-01-7

Spironolactone

Formula: C₂₄H₃₂O₄S

Purity: ≥95%

Molecular weight: 416.579

Ref: 54-OR98301

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Color and Shape: Off-White Solid

Molecular weight: 416.58

Ref: 4Z-S-083

Spironolactone-d3 (Major)

CAS: 52-01-7

Formula: C₂₄H₂₉D₃O₄S

Color and Shape: Off-White To Pale Yellow Solid

Molecular weight: 419.59

Ref: 4Z-S-082

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purity: (HPLC) ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 416.58

Ref: 7W-GP5407

Spironolactone, Ph. Eur. grade

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purity: ≤ 0.1%

Color and Shape: White or pale yellow powder

Molecular weight: 416.58

Ref: 7W-GP2110

Spironolactone

CAS: 52-01-7

Color and Shape: Neat

Ref: 61-FOR0197.00

Spironolactone

Controlled Product

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Color and Shape: Neat

Molecular weight: 416.57

Ref: 04-C16972980

Spironolactone

CAS: 52-01-7

Color and Shape: Neat

Ref: 86-MM0197.00

Sugammadex Impurity 77

CAS: 52-01-7

Formula: C₈₇H₁₁₄O₄₈PS₇·7Na

Color and Shape: Off-White To Pale Yellow Solid

Molecular weight: 2183.22 7*22.99

Ref: 4Z-S-082080

Spironolactone-d3

Controlled Product

CAS: 52-01-7

Applications Spironolactone-d3 is the labeled analogue of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975)

Formula: C₂₄H₂₉D₃O₄S

Color and Shape: Neat

Molecular weight: 419.59

Ref: TR-S683003

Spironolactone-d7 (Major)

Controlled Product

CAS: 52-01-7

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. A representative lot was 19% d3; 47% d6; 12% d7; 7% d8; 3% d9; 3% d10 and 8% d11.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

Formula: C₂₄H₂₅D₇O₄S

Color and Shape: Neat

Molecular weight: 423.62

Ref: TR-S683002

Spironolactone

Controlled Product

CAS: 52-01-7

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

Formula: C₂₄H₃₂O₄S

Color and Shape: Neat

Molecular weight: 416.57

Ref: TR-S683000

Spironolactone

Controlled Product

CAS: 52-01-7

Mineralocorticoid (aldosterone) receptor antagonist; anti-hypertensive

Formula: C₂₄H₃₂O₄S

Purity: (%) Min. 95%

Color and Shape: White Powder

Molecular weight: 416.57 g/mol

Ref: 3D-FS15791

Spironolactone - Bio-X ™

Controlled Product

CAS: 52-01-7

Spironolactone is an aldosterone receptor antagonist that is used to treat hypertension, heart failure and edema. This drug binds to mineralocorticoid receptors and acts as an aldosterone antagonist. Spironolactone promotes sodium and water excretion and potassium retention. It also activates pro-inflammatory pathways.

Formula: C₂₄H₃₂O₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 416.57 g/mol

Ref: 3D-BS166385

Spironolactone extrapure, 97%

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Purity: min. 97%

Color and Shape: White, Powder

Molecular weight: 416.60

Ref: SR-67715

Spironolactone

CAS: 52-01-7

Formula: C₂₄H₃₂O₄S

Molecular weight: 416.58

Ref: ST-EA-CP-S10000

Spironolactone 1.0 mg/ml in Acetonitrile

CAS: 52-01-7

Color and Shape: Single Solution

Ref: 61-AMP0197.00-11

Spironolactone RS

CAS: 52-01-7

Color and Shape: White

Ref: 2K-1074000021