CAS 52-01-7

Spironolactone

Description:

Spironolactone is a synthetic steroidal compound primarily used as a diuretic and antihypertensive agent. It functions as an aldosterone antagonist, inhibiting the action of aldosterone in the kidneys, which promotes sodium and water excretion while conserving potassium. This mechanism makes it effective in treating conditions such as hypertension, heart failure, and certain cases of edema. Spironolactone is also utilized in the management of conditions like hyperaldosteronism and can be beneficial in treating acne and hirsutism due to its anti-androgenic properties. The compound is typically administered orally and has a relatively long half-life, allowing for once-daily dosing in many cases. In terms of its chemical structure, spironolactone features a lactone ring and a thioester group, contributing to its pharmacological activity. Common side effects may include hyperkalemia, gastrointestinal disturbances, and hormonal imbalances. Due to its hormonal effects, spironolactone is sometimes used off-label in hormone therapy for transgender individuals. Overall, spironolactone is a versatile medication with significant therapeutic applications in various medical conditions.

Formula:C₂₄H₃₂O₄S

InChI:InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

InChI key:InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N

SMILES:C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3

Synonyms:

(7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone
17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate
17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate
3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone
3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone
3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-
7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone
Abbolactone
Aldace
Aldactone
Aldactone A
Aldopur
Almatol
Altex
Aquareduct
Berlactone
Deverol
Diatensec
Dira
Duraspiron
Espironolactona
Euteberol
Lacalmin
Lacdene
Laractone
Nefurofan
Novo-Spiroton
Nsc 150399
Osiren
Osyrol
Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-
Quimolactona
S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate
S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
Sagisal
Sc 9420
Sincomen
Spiresis
Spiretic
Spiridon
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.
Spiroctan
Spiroderm
Spirolactone
Spirolang
Spirolone
Spirone
Spironol
Spironolacton
Spironolactone A
Supra-Puren
Suracton
Uractone
Urusonin
Verospiron
Verospirone
Xenalon
See more synonyms

Purity (%)

100

products per page.Found 27 products.

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Spironolactone-d3
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52-01-7
Applications Spironolactone-d3 is the labeled analogue of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975) 
Formula:C₂₄H₂₉D₃O₄S
Color and Shape:Yellow Solid
Molecular weight:419.59
Ref: TR-S683003
1mg
320.00€
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10mg
1,987.00€
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Spironolactone
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52-01-7
Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975), 
Formula:C₂₄H₃₂O₄S
Color and Shape:Off-White
Molecular weight:416.57
Ref: TR-S683000
1g
120.00€
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5g
242.00€
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50mg
113.00€
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Spironolactone-d7 (Major)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52-01-7
Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. A representative lot was 19% d3; 47% d6; 12% d7; 7% d8; 3% d9; 3% d10 and 8% d11. References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975), 
Formula:C₂₄H₂₅D₇O₄S
Color and Shape:Neat
Molecular weight:423.62
Ref: TR-S683002
1mg
269.00€
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10mg
1,813.00€
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Spironolactone
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52-01-7
Mineralocorticoid (aldosterone) receptor antagonist; anti-hypertensive
Formula:C₂₄H₃₂O₄S
Purity:Min. 97 Area-%
Color and Shape:White Powder
Molecular weight:416.57 g/mol
Ref: 3D-FS15791
25g
200.00€
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50g
321.00€
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100g
462.00€
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250g
874.00€
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500g
1,255.00€
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Spironolactone - Bio-X ™
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52-01-7
Spironolactone is an aldosterone receptor antagonist that is used to treat hypertension, heart failure and edema. This drug binds to mineralocorticoid receptors and acts as an aldosterone antagonist. Spironolactone promotes sodium and water excretion and potassium retention. It also activates pro-inflammatory pathways.
Formula:C₂₄H₃₂O₄S
Purity:Min. 95%
Color and Shape:Powder
Molecular weight:416.57 g/mol
Ref: 3D-BS166385
100mg
134.00€
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Spironolactone extrapure, 97%
CAS:
- 52-01-7
Formula:C₂₄H₃₂O₄S
Purity:min. 97%
Color and Shape:White, Powder
Molecular weight:416.60
Ref: SR-67715
1g
48.00€
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5g
119.00€
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17-Hydroxy-7-α-mercapto-3-oxo-17-α-pregn-4-ene-21-carboxylic acid-γ-lactone-7-acetate
CAS:
- 52-01-7
Formula:C₂₄H₃₂O₄S
Purity:97%
Color and Shape:Solid
Molecular weight:416.5735
Ref: IN-DA00DE6I
1g
Discontinued
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5g
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25g
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250mg
Discontinued
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Discontinued product