CAS 52-24-4

Thiotepa

Description:

Thiotepa, with the CAS number 52-24-4, is a chemical compound classified as an alkylating agent, primarily used in chemotherapy for treating various cancers. It is a colorless to pale yellow liquid that is soluble in water and organic solvents. The molecular structure of thiotepa includes a nitrogen atom and a sulfur atom, which contribute to its reactivity. As an alkylating agent, thiotepa works by forming covalent bonds with DNA, leading to cross-linking and ultimately inhibiting cell division, which is particularly effective against rapidly dividing cancer cells. Its use is associated with a range of side effects, including myelosuppression, which can lead to decreased blood cell counts, and other toxicities affecting various organ systems. Due to its potent effects and potential for toxicity, thiotepa is typically administered under strict medical supervision. Safety precautions are essential when handling thiotepa, as it is considered hazardous. Overall, thiotepa plays a significant role in oncology, particularly in combination therapies for certain malignancies.

Formula: C₆H₁₂N₃PS

InChI: InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

InChI key: InChIKey=FOCVUCIESVLUNU-UHFFFAOYSA-N

SMILES: P(=S)(N1CC1)(N2CC2)N3CC3

Synonyms:

• 1,1',1''-Phosphinothioylidynetrisaziridine
• 1,1′,1′′-Phosphinothioylidynetris[aziridine]
• Ai 3-24916
• Aziridine, 1,1′,1′′-phosphinothioylidynetris-
• Cbc 806495
• Girostan
• N,N',N''-Triethylenethiophosphoramide
• N,N',N''-Triethylenethiophosphortriamide
• Nci C01649
• Nsc 6396
• Oncotepa
• Oncothio-tepa
• Oncotiotepa
• Phosphine sulfide, tris(1-aziridinyl)-
• Phosphorothioic acid triethylenetriamide
• Phosphorothioic triamide, N,N',N''-tri-1,2-ethanediyl-
• Sk 6882
• Stepa
• Tepadina
• Tespa
• Tespamin
• Tespamine
• Thio-Tep
• Thio-Tepa S
• Thiofozil
• Thiophosphamide
• Thiophosphoramide, N,N',N''-tri-1,2-ethanediyl-
• Thioplex
• Thiotef
• Thiotepa
• Thiotriethylenephosphoramide
• Tio-TEF
• Tiofosfamid
• Tiofosyl
• Tiofozil
• Tiotepa
• Tri(ethyleneimino)thiophosphoramide
• Tri-1-aziridinylphosphine sulfide
• Triaziridinylphosphine sulfide
• Triaziridinylphosphinesulfide
• Triethylenethiophosphoramide
• Triethylenethiophosphorotriamide
• Tris(1-aziridinyl)phosphine sulfide
• Tris(aziridinyl)phosphine sulfide
• Tris(aziridinyl)phosphine-thioxide
• Tris-(1-Aziridinyl)-Phosphin-Sulfid

Thiotepa

CAS: 52-24-4

Thiotepa

Formula: C₆H₁₂N₃PS

Purity: 98.7%

Color and Shape: White Solid

Molecular weight: 189.04896

Ref: 47-331

Thiotepa

CAS: 52-24-4

Heterocyclic compounds with nitrogen hetero-atom(s) only, excluding aromatic or modified aromatic

Formula: C₆H₁₂N₃PS

Color and Shape: White Flakes

Molecular weight: 189.04896

Ref: 45-1664000

Thio-TEPA

CAS: 52-24-4

Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.

Formula: C₆H₁₂N₃PS

Purity: 98.45% - 99.07%

Color and Shape: White Crystals Or Powder

Molecular weight: 189.22

Ref: TM-T1250

Thio-TEPA

CAS: 52-24-4

Thio-TEPA

Purity: ≥98%

Molecular weight: 189.22g/mol

Ref: 54-BUP15600

Thio-TEPA

CAS: 52-24-4

Formula: C₆H₁₂N₃PS

Purity: ≥ 98.0%

Color and Shape: White crystalline powder

Molecular weight: 189.22

Ref: 7W-GP6020

Thiotepa

CAS: 52-24-4

Formula: C₆H₁₂N₃PS

Molecular weight: 189.22

Ref: 4Z-T-184001

Thiotepa

CAS: 52-24-4

Formula: C₆H₁₂N₃PS

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 189.22

Ref: 3B-T4184

Triethylenethiophosphoramide

Controlled Product

CAS: 52-24-4

Applications This substance is listed as a known human carcinogen. It is useful for the treatment of cancers, especially cancers resistant to chemotherapy. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kyriakou, C., et al.: J. Clin. Oncol., 27, 3262 (2009),

Formula: C₆H₁₂N₃PS

Color and Shape: Neat

Molecular weight: 189.22

Ref: TR-T776650

Thiotepa

CAS: 52-24-4

Thiotepa is commonly used in the treatment of cancer. It has been shown to inhibit the growth of tumor cells by inhibiting lipid kinase activity and uptake, which leads to tumor cell death. This drug also inhibits antibody response in t47d cells and has been shown to be effective in the diagnosis of infectious diseases such as tuberculosis, chlamydia, and mycoplasma. Thiotepa is a chiral compound that can exist in either the L- or D- form. The D- form of thiotepa has been found to have more potent antitumor effects than the L- form. A recent study on animal tumors showed that ganoderma lucidum was able to increase the antitumor activity of thiotepa.

Formula: C₆H₁₂N₃PS

Purity: (31P-Nmr) Min. 95%

Color and Shape: Powder

Molecular weight: 189.22 g/mol

Ref: 3D-FT03758