CAS 52-39-1

(+)-Aldosterone

Description:

(+)-Aldosterone, with the CAS number 52-39-1, is a steroid hormone produced by the adrenal cortex, playing a crucial role in regulating sodium and potassium levels in the body, thus influencing blood pressure and fluid balance. It is classified as a mineralocorticoid and is derived from cholesterol. The chemical structure of aldosterone includes a cyclopentanoperhydrophenanthrene core, characteristic of steroid hormones, with specific functional groups that facilitate its biological activity. It acts primarily on the kidneys, promoting sodium reabsorption and potassium excretion, which helps maintain electrolyte balance. Aldosterone's secretion is regulated by the renin-angiotensin-aldosterone system (RAAS) and is influenced by factors such as blood volume, blood pressure, and plasma sodium concentration. In clinical contexts, abnormal levels of aldosterone can indicate various health issues, including hypertension and adrenal disorders. Its synthesis and action are critical for homeostasis, making it an important target for pharmacological intervention in conditions like heart failure and hypertension.

Formula: C₂₁H₂₈O₅

InChI: InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI key: InChIKey=PQSUYGKTWSAVDQ-ZVIOFETBSA-N

SMILES: C(=O)[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@H]2C(CO)=O)[H]

Synonyms:

• (11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
• 11β,21-Dihydroxy-3,20-diketo-4-pregnen-18-al
• 11β,21-Dihydroxy-3,20-diketopregn-4-ene-18-al
• 11β,21-Dihydroxypregn-4-ene-3,18,20-trione
• 18-Formyl-11β,21-dihydroxy-4-pregnene-3,20-dione
• 18-Oxocorticosterone
• Aldocorten
• Aldocortene
• Aldocortin
• Aldosteron
• Aldosterona
• Electrocortin
• Elektrocortin
• Nsc 73856
• Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11β)-
• Reichstein X
• d-Aldosterone

Aldosterone

CAS: 52-39-1

Formula: C₂₁H₂₈O₅

Purity: ≥ 95.0%

Color and Shape: White to light-yellow crystalline powder

Molecular weight: 360.44

Ref: 7W-GP9240

Aldosterone

CAS: 52-39-1

Aldosterone, the main mineralocorticoid, is made by the adrenal cortex's zona glomerulosa and released when renin-angiotensin activates or potassium is high.

Formula: C₂₁H₂₈O₅

Purity: 96.15% - 99%

Color and Shape: Solid

Molecular weight: 360.44

Ref: TM-T19186

Aldosterone 100 µg/mL in Acetonitrile

CAS: 52-39-1

Formula: C₂₁H₂₈O₅

Color and Shape: Single Solution

Molecular weight: 360.44

Ref: 04-A10085000AL-100

Aldosterone-d7 (Major)

Controlled Product

CAS: 52-39-1

Formula: C₂₁H₂₁D₇O₅

Color and Shape: Neat

Molecular weight: 367.49

Ref: TR-A514702

Aldosterone

CAS: 52-39-1

Applications Aldosterone is an adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex that induces urinary excretion of K+ and renal reabsorptioon of Na+. Exists as an equilibrium mixture of the aldehyde and the hemiacetal.
References Simpson, et al.: Experienta, 9, 333 (1953), Morel, A., et al.: Nature, 356, 523 (1992), Arima, S., et al.: Clin. Exp. Nephrol., 7, 172 (2003), Hirasawa, A., et al.: Eur. J. Pharmacol., 267, 71 (1994), Hiroyama, M., et al.: Mol. Endocrinol., 21, 247 (2007),

Formula: C₂₁H₂₈O₅

Color and Shape: White To Off-White

Molecular weight: 360.44

Ref: TR-A514700

Aldosterone

Controlled Product

CAS: 52-39-1

Aldosterone is a steroid hormone, which is a key product of the adrenal cortex. It originates from cholesterol through a series of intricate enzymatic conversions within the zona glomerulosa of the adrenal glands. Its primary mode of action involves binding to mineralocorticoid receptors in the distal nephron of the kidney. This binding triggers the transcription of specific genes, promoting the reabsorption of sodium ions and the excretion of potassium ions. Consequently, this action increases water retention and elevates blood volume and blood pressure.

Formula: C₂₁H₂₈O₅

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 360.44 g/mol

Ref: 3D-FA17269

Aldosterone-d4

Controlled Product

CAS: 52-39-1

Formula: C₂₁D₄H₂₄O₅

Color and Shape: Neat

Molecular weight: 364.469

Ref: TR-A514703

ALDOSTERONE CMO BIOTIN

Controlled Product

CAS: 52-39-1

Formula: C₃₆H₅₃N₅O₈S

Color and Shape: Neat

Molecular weight: 715.9

Ref: TR-A514715

Aldosterone (1 mg/mL in Acetonitrile)

Controlled Product

CAS: 52-39-1

Formula: C₂₁H₂₈O₅

Color and Shape: Colourless

Molecular weight: 360.44

Ref: TR-KIT0300

Aldosterone-13C3

Controlled Product

CAS: 52-39-1

Formula: C₃C₁₈H₂₈O₅

Color and Shape: Neat

Molecular weight: 363.42

Ref: TR-A514701

Aldosterone

CAS: 52-39-1

Formula: C₂₁H₂₈O₅

Molecular weight: 360.45

Ref: ST-EA-CP-A321000

Aldosterone

CAS: 52-39-1

Formula: C₂₁H₂₈O₅

Molecular weight: 360.45

Ref: 4Z-A-853

Aldosterone-d7

CAS: 52-39-1

Formula: C₂₁H₂₁D₇O₅

Molecular weight: 367.49

Ref: 4Z-A-854