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CAS 52-49-3

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(±)-Trihexyphenidyl hydrochloride

Description:
(±)-Trihexyphenidyl hydrochloride is a synthetic anticholinergic medication primarily used to treat Parkinson's disease and drug-induced extrapyramidal symptoms. It functions by blocking the action of acetylcholine at muscarinic receptors, which helps to alleviate symptoms such as tremors and rigidity. The compound appears as a white to off-white crystalline powder and is soluble in water and alcohol, which facilitates its administration in various forms. Its chemical structure includes a phenyl ring and a piperidine moiety, contributing to its pharmacological activity. The hydrochloride salt form enhances its stability and solubility. Common side effects may include dry mouth, blurred vision, constipation, and urinary retention, reflecting its anticholinergic properties. Due to its potential for central nervous system effects, caution is advised in patients with a history of glaucoma or urinary retention. Overall, (±)-Trihexyphenidyl hydrochloride is an important therapeutic agent in managing movement disorders, although it requires careful monitoring for adverse effects.
Formula:C20H31NO·ClH
InChI:InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
InChI key:InChIKey=QDWJJTJNXAKQKD-UHFFFAOYSA-N
SMILES:C(CCN1CCCCC1)(O)(C2CCCCC2)C3=CC=CC=C3.Cl
Synonyms:
  • 1-Cyclohexyl-1-Phenyl-3-(1-Piperidyl)Propan-1-Ol Hydrochloride
  • 1-Cyclohexyl-1-Phenyl-3-(Piperidin-1-Yl)Propan-1-Ol Hydrochloride (1:1)
  • 1-Cyclohexyl-1-Phenyl-3-Piperidine Propanol Hydrochloride
  • 1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride
  • 1-Phenyl-1-cyclohexyl-3-piperidyl-1-propanol hydrochloride
  • 1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride
  • 1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride (1:1)
  • 3-(1-Piperidyl)-1-cyclohexyl-1-phenyl-1-propanol hydrochloride
  • 3-(1-Piperidyl)-1-phenyl-1-cyclohexyl-1-propanol hydrochloride
  • Alpha-Cyclohexyl-alpha-phenyl-1-piperidinepropanol hydrochloride
  • See more synonyms
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