CAS 52-53-9

Verapamil

Description:

Verapamil is a calcium channel blocker primarily used in the treatment of hypertension, angina pectoris, and certain types of arrhythmias. It functions by inhibiting the influx of calcium ions through L-type calcium channels in cardiac and smooth muscle cells, leading to vasodilation and decreased heart rate. This compound is classified as a phenylalkylamine and has a complex structure that includes a benzene ring, a piperidine ring, and an isopropyl side chain. Verapamil is typically administered orally or intravenously and is known for its relatively high bioavailability. Its pharmacokinetics involve extensive hepatic metabolism, primarily by cytochrome P450 enzymes, resulting in various metabolites. Common side effects may include hypotension, bradycardia, and gastrointestinal disturbances. Due to its interaction with other medications, careful consideration is necessary when prescribing Verapamil, particularly in patients taking other drugs that affect cardiac function or hepatic metabolism. Overall, Verapamil remains a vital therapeutic agent in cardiovascular medicine.

Formula: C₂₇H₃₈N₂O₄

InChI: InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3

InChI key: InChIKey=SGTNSNPWRIOYBX-UHFFFAOYSA-N

SMILES: C(CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2

Synonyms:

• (.+-.)-Verapamil
• 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
• 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-(propan-2-yl)pentanenitrile
• 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-isopropylpentanenitrile
• 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxy phenyl)-2-isopropylvaleronitrile
• Cp 16533-1
• D 365
• Iproveratril
• Lekoptin
• Nsc 272306Na
• R,S-Verapamil
• VPL
• Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-
• Verapamilo
• dl-Verapamil
• α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile

Verapamil Hydrochloride

CAS: 152-11-4, 52-53-9

Formula: C₂₇H₃₈N₂O₄·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 491.07

Ref: 3B-V0118

Verapamil

CAS: 52-53-9

Verapamil

Purity: 98%

Molecular weight: 454.6g/mol

Ref: 54-OR1026231

Verapamil

CAS: 52-53-9

Verapamil

Purity: ≥98%

Molecular weight: 454.6g/mol

Ref: 54-BUP15658

Verapamil

CAS: 52-53-9

Verapamil is a calcium antagonist that blocks the influx of extracellular calcium and inhibits the release of calcium from intracellular storage sites. Verapamil may be used to treat hypertension, angina pectoris, and arrhythmias. This drug is also used as a diagnostic agent in studies of the cardiovascular system. Verapamil has been shown to reduce ventricular systolic dysfunction and cardiovascular morbidity in patients with chronic heart failure. The elimination half-life of verapamil ranges from 5 to 8 hours, depending on dose. It is eliminated primarily by renal excretion with less than 1% being metabolized in the liver.

Formula: C₂₇H₃₈N₂O₄

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 454.6 g/mol

Ref: 3D-FV02354

Verapamil

CAS: 52-53-9

Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.

Formula: C₂₇H₃₈N₂O₄

Purity: 99.61% - 99.93%

Color and Shape: Oil

Molecular weight: 454.6

Ref: TM-T20656

Verapamil

CAS: 52-53-9

Formula: C₂₇H₃₈N₂O₄

Molecular weight: 454.61

Ref: ST-EA-CP-V10016