CAS 52049-26-0

1-(2-chloroethyl)-3-(4-hydroxycyclohexyl)-1-nitrosourea

Description:

1-(2-Chloroethyl)-3-(4-hydroxycyclohexyl)-1-nitrosourea, with the CAS number 52049-26-0, is a synthetic organic compound that belongs to the class of nitrosoureas, which are known for their alkylating properties. This compound features a chloroethyl group, which contributes to its reactivity, and a hydroxycyclohexyl moiety that may influence its biological activity and solubility. Nitrosoureas are characterized by their ability to form DNA cross-links, making them significant in cancer chemotherapy, particularly for treating certain types of tumors. The presence of the nitrosourea functional group allows for the release of reactive species that can interact with nucleophilic sites in DNA. Additionally, this compound may exhibit moderate to high lipophilicity due to its cyclohexyl structure, potentially affecting its pharmacokinetics and distribution in biological systems. Safety and handling precautions are essential, as nitrosoureas can be toxic and carcinogenic. Overall, this compound's unique structure and properties make it a subject of interest in medicinal chemistry and cancer research.

Formula: C₉H₁₆ClN₃O₃

InChI: InChI=1/C9H16ClN3O3/c10-5-6-13(12-16)9(15)11-7-1-3-8(14)4-2-7/h7-8,14H,1-6H2,(H,11,15)

SMILES: C1CC(CCC1N=C(N(CCCl)N=O)O)O

Synonyms:

• Lomustine cis-4-Hydroxy Impurity
• Urea, N-(2-chloroethyl)-N'-(cis-4-hydroxycyclohexyl)-N-nitroso-
• Urea, 1-(2-chloroethyl)-3-(cis-4-hydroxycyclohexyl)-1-nitroso-
• 1-(2-chloroethyl)-3-(4-hydroxycyclohexyl)-1-nitroso-urea

cis-4’-Hydroxy CCNU Lomustine

CAS: 52049-26-0

Formula: C₉H₁₆ClN₃O₃

Color and Shape: Off-White Solid

Molecular weight: 249.70

Ref: 4Z-L-114002

cis-4-Hydroxy-lomustine

CAS: 52049-26-0

Cis-4-hydroxy-lomustine is a carbamylated prodrug that is converted to the active form, lomustine, by hydrolysis. It has high lipophilicity and is readily taken up by tissues. Cis-4-hydroxy-lomustine inhibits the growth of cancer cells by binding to DNA and blocking RNA synthesis. The drug also inhibits the activity of pyridinium crosslinks in proteins and nitroimidazole drugs in microorganisms. Cis-4-hydroxy-lomustine does not undergo extensive metabolism in the body, but undergoes rapid conversion to the active form, which is excreted mainly as unchanged drug in urine. Cis-4-hydroxy-lomustine has been shown to be effective against colorectal cancer cells with wild type p53 tumor suppressor gene and against small cell lung cancer cells with mutant p53 tumor suppressor

Formula: C₉H₁₆ClN₃O₃

Purity: Min. 95%

Molecular weight: 249.69 g/mol

Ref: 3D-CCA04926

cis-4’-Hydroxy CCNU Lomustine

CAS: 52049-26-0

Formula: C₉H₁₆ClN₃O₃

Molecular weight: 249.70

Ref: ST-EA-CP-L25060